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Artificial sweeteners and the risk of gastric, pancreatic, and endometrial cancers in Italy.

Abstract

BACKGROUND

The role of sweeteners on cancer risk has been widely debated over the last few decades. To provide additional information on saccharin and other artificial or low-calorie sweeteners (mainly aspartame), we updated the analysis of an integrated network of case-control studies conducted in Italy between 1991 and 2004 including data on cancers of the stomach, pancreas, and endometrium.

PATIENTS AND METHODS

Cases were 230 patients with incident, histologically confirmed cancers of the stomach and 547 corresponding controls, 326 of the pancreas and 652 controls, and 454 of the endometrium and 908 controls. All controls were patients admitted to the same hospitals as cases for acute, non-neoplastic disorders. Odds ratios (OR) and corresponding confidence intervals (CI) were derived by unconditional logistic regression models.

RESULTS

After allowance for various confounding factors, ORs for ever users of sweeteners versus nonusers were 0.80 (95% CI, 0.45-1.43) for gastric cancer, 0.62 (95% CI, 0.37-1.04) for pancreatic cancer, and 0.96 (95% CI, 0.67-1.40) for endometrial cancer. Corresponding ORs for saccharin were 0.65, 0.19, and 0.71, and for other sweeteners were 0.86, 1.16, and 1.07, respectively, for the three cancer sites.

CONCLUSIONS

The present study adds further evidence on the absence of an adverse effect of low-calorie sweetener (including aspartame) consumption on the risk of common neoplams in the Italian population.

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  • Authors+Show Affiliations

    ,

    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy. bosetti@marionegri.it

    , , , , ,

    Source

    MeSH

    Adult
    Aged
    Aged, 80 and over
    Case-Control Studies
    Endometrial Neoplasms
    Female
    Humans
    Italy
    Male
    Middle Aged
    Odds Ratio
    Pancreatic Neoplasms
    Risk Factors
    Stomach Neoplasms
    Sweetening Agents

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    19661082

    Citation

    Bosetti, Cristina, et al. "Artificial Sweeteners and the Risk of Gastric, Pancreatic, and Endometrial Cancers in Italy." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 18, no. 8, 2009, pp. 2235-8.
    Bosetti C, Gallus S, Talamini R, et al. Artificial sweeteners and the risk of gastric, pancreatic, and endometrial cancers in Italy. Cancer Epidemiol Biomarkers Prev. 2009;18(8):2235-8.
    Bosetti, C., Gallus, S., Talamini, R., Montella, M., Franceschi, S., Negri, E., & La Vecchia, C. (2009). Artificial sweeteners and the risk of gastric, pancreatic, and endometrial cancers in Italy. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 18(8), pp. 2235-8. doi:10.1158/1055-9965.EPI-09-0365.
    Bosetti C, et al. Artificial Sweeteners and the Risk of Gastric, Pancreatic, and Endometrial Cancers in Italy. Cancer Epidemiol Biomarkers Prev. 2009;18(8):2235-8. PubMed PMID: 19661082.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Artificial sweeteners and the risk of gastric, pancreatic, and endometrial cancers in Italy. AU - Bosetti,Cristina, AU - Gallus,Silvano, AU - Talamini,Renato, AU - Montella,Maurizio, AU - Franceschi,Silvia, AU - Negri,Eva, AU - La Vecchia,Carlo, PY - 2009/8/8/entrez PY - 2009/8/8/pubmed PY - 2009/10/21/medline SP - 2235 EP - 8 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 18 IS - 8 N2 - BACKGROUND: The role of sweeteners on cancer risk has been widely debated over the last few decades. To provide additional information on saccharin and other artificial or low-calorie sweeteners (mainly aspartame), we updated the analysis of an integrated network of case-control studies conducted in Italy between 1991 and 2004 including data on cancers of the stomach, pancreas, and endometrium. PATIENTS AND METHODS: Cases were 230 patients with incident, histologically confirmed cancers of the stomach and 547 corresponding controls, 326 of the pancreas and 652 controls, and 454 of the endometrium and 908 controls. All controls were patients admitted to the same hospitals as cases for acute, non-neoplastic disorders. Odds ratios (OR) and corresponding confidence intervals (CI) were derived by unconditional logistic regression models. RESULTS: After allowance for various confounding factors, ORs for ever users of sweeteners versus nonusers were 0.80 (95% CI, 0.45-1.43) for gastric cancer, 0.62 (95% CI, 0.37-1.04) for pancreatic cancer, and 0.96 (95% CI, 0.67-1.40) for endometrial cancer. Corresponding ORs for saccharin were 0.65, 0.19, and 0.71, and for other sweeteners were 0.86, 1.16, and 1.07, respectively, for the three cancer sites. CONCLUSIONS: The present study adds further evidence on the absence of an adverse effect of low-calorie sweetener (including aspartame) consumption on the risk of common neoplams in the Italian population. SN - 1538-7755 UR - https://www.unboundmedicine.com/medline/citation/19661082/Artificial_sweeteners_and_the_risk_of_gastric_pancreatic_and_endometrial_cancers_in_Italy_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=19661082 DB - PRIME DP - Unbound Medicine ER -