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[Effectiveness of Kampo medicine Gorei-San for chronic subdural hematoma].
No Shinkei Geka. 2009 Aug; 37(8):765-70.NS

Abstract

Chronic subdural hematomas (CSDHs) are basically treated by surgery. In some cases with no or minimum symptoms, however, they may be treated conservatively. In the present study, we evaluated the therapeutic effect of a Kampo medicine (Japanese traditional herbal medicine), Gorei-san, in the treatment of those CSDHs. Gorei-san 7.5 g t.i.d. was orally administered for 4 weeks in 22 patients with 27 CSDHs. Maximum thickness of the hematoma was followed up on CT scan for 4 to 29 weeks after administration of Gorei-san. In 7 of 22 patients, tranexamic acid and/or carbazochrome sodium sulfonate were also administrated. Gorei-san was effective in 23 of 27 CSDHs. In 12 of them, the hematoma was completely disappeared within 14 weeks after administration. In the other 11 CSDHs, the thickness was decreased. In those effective cases, thickness began to decrease 3 to 4 weeks after administration of Gorei-san. It was more effective in CSDHs with iso-/high or mixed density than with low density on CT. It was not effective in 4 out of 27 CSDHs. No apparent adverse effect was noted in the present series of patients. The present study suggests that a Kampo medicine, Gorei-san, is a useful option in the conservative treatment of CSDHs with no or minimum symptoms.

Authors+Show Affiliations

Department of Neurosurgery, Sonoda Daiichi Hospital, Japan.No affiliation info available

Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

jpn

PubMed ID

19663334

Citation

Miyagami, Mitsusuke, and Yukihide Kagawa. "[Effectiveness of Kampo Medicine Gorei-San for Chronic Subdural Hematoma]." No Shinkei Geka. Neurological Surgery, vol. 37, no. 8, 2009, pp. 765-70.
Miyagami M, Kagawa Y. [Effectiveness of Kampo medicine Gorei-San for chronic subdural hematoma]. No Shinkei Geka. 2009;37(8):765-70.
Miyagami, M., & Kagawa, Y. (2009). [Effectiveness of Kampo medicine Gorei-San for chronic subdural hematoma]. No Shinkei Geka. Neurological Surgery, 37(8), 765-70.
Miyagami M, Kagawa Y. [Effectiveness of Kampo Medicine Gorei-San for Chronic Subdural Hematoma]. No Shinkei Geka. 2009;37(8):765-70. PubMed PMID: 19663334.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effectiveness of Kampo medicine Gorei-San for chronic subdural hematoma]. AU - Miyagami,Mitsusuke, AU - Kagawa,Yukihide, PY - 2009/8/12/entrez PY - 2009/8/12/pubmed PY - 2009/9/26/medline SP - 765 EP - 70 JF - No shinkei geka. Neurological surgery JO - No Shinkei Geka VL - 37 IS - 8 N2 - Chronic subdural hematomas (CSDHs) are basically treated by surgery. In some cases with no or minimum symptoms, however, they may be treated conservatively. In the present study, we evaluated the therapeutic effect of a Kampo medicine (Japanese traditional herbal medicine), Gorei-san, in the treatment of those CSDHs. Gorei-san 7.5 g t.i.d. was orally administered for 4 weeks in 22 patients with 27 CSDHs. Maximum thickness of the hematoma was followed up on CT scan for 4 to 29 weeks after administration of Gorei-san. In 7 of 22 patients, tranexamic acid and/or carbazochrome sodium sulfonate were also administrated. Gorei-san was effective in 23 of 27 CSDHs. In 12 of them, the hematoma was completely disappeared within 14 weeks after administration. In the other 11 CSDHs, the thickness was decreased. In those effective cases, thickness began to decrease 3 to 4 weeks after administration of Gorei-san. It was more effective in CSDHs with iso-/high or mixed density than with low density on CT. It was not effective in 4 out of 27 CSDHs. No apparent adverse effect was noted in the present series of patients. The present study suggests that a Kampo medicine, Gorei-san, is a useful option in the conservative treatment of CSDHs with no or minimum symptoms. SN - 0301-2603 UR - https://www.unboundmedicine.com/medline/citation/19663334/[Effectiveness_of_Kampo_medicine_Gorei_San_for_chronic_subdural_hematoma]_ L2 - https://webview.isho.jp/openurl?rft.genre=article&rft.issn=0301-2603&rft.volume=37&rft.issue=8&rft.spage=765 DB - PRIME DP - Unbound Medicine ER -