Tags

Type your tag names separated by a space and hit enter

Epstein-Barr virus in multiple sclerosis.
Curr Neurol Neurosci Rep 2009; 9(5):405-10CN

Abstract

Recent seroepidemiologic and pathologic evidence suggests that prior infection with Epstein-Barr virus (EBV) may be necessary for the development of multiple sclerosis (MS). EBV infects more than 90% of all humans, most of whom remain healthy. In contrast, 99% of MS patients have evidence of prior infection with EBV. EBV infects resting B lymphocytes, immortalizing them into long-lived memory B cells that survive largely undetected by the immune system in the peripheral circulation. MS patients show elevated titers to EBV years before developing any neurologic symptoms. Postmortem pathologic analysis of brains of patients with MS has revealed diffuse EBV-associated B-cell dysregulation in all forms of MS. Theories of pathogenesis of EBV in MS include antigenic mimicry, immortalization of B-cell clones, and cytotoxic T-cell dysfunction against virally infected B cells. This article reviews the existing evidence of the relationship between EBV and MS and considers the therapeutic implication of this evidence.

Authors+Show Affiliations

Department of Neurology, 1542 Tulane Avenue, Room 718B, Louisiana State University Health Science Center, New Orleans, LA 70112, USA. bbager@lsuhsc.edu

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19664371

Citation

Bagert, Bridget A.. "Epstein-Barr Virus in Multiple Sclerosis." Current Neurology and Neuroscience Reports, vol. 9, no. 5, 2009, pp. 405-10.
Bagert BA. Epstein-Barr virus in multiple sclerosis. Curr Neurol Neurosci Rep. 2009;9(5):405-10.
Bagert, B. A. (2009). Epstein-Barr virus in multiple sclerosis. Current Neurology and Neuroscience Reports, 9(5), pp. 405-10.
Bagert BA. Epstein-Barr Virus in Multiple Sclerosis. Curr Neurol Neurosci Rep. 2009;9(5):405-10. PubMed PMID: 19664371.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Epstein-Barr virus in multiple sclerosis. A1 - Bagert,Bridget A, PY - 2009/8/12/entrez PY - 2009/8/12/pubmed PY - 2009/8/29/medline SP - 405 EP - 10 JF - Current neurology and neuroscience reports JO - Curr Neurol Neurosci Rep VL - 9 IS - 5 N2 - Recent seroepidemiologic and pathologic evidence suggests that prior infection with Epstein-Barr virus (EBV) may be necessary for the development of multiple sclerosis (MS). EBV infects more than 90% of all humans, most of whom remain healthy. In contrast, 99% of MS patients have evidence of prior infection with EBV. EBV infects resting B lymphocytes, immortalizing them into long-lived memory B cells that survive largely undetected by the immune system in the peripheral circulation. MS patients show elevated titers to EBV years before developing any neurologic symptoms. Postmortem pathologic analysis of brains of patients with MS has revealed diffuse EBV-associated B-cell dysregulation in all forms of MS. Theories of pathogenesis of EBV in MS include antigenic mimicry, immortalization of B-cell clones, and cytotoxic T-cell dysfunction against virally infected B cells. This article reviews the existing evidence of the relationship between EBV and MS and considers the therapeutic implication of this evidence. SN - 1534-6293 UR - https://www.unboundmedicine.com/medline/citation/19664371/Epstein_Barr_virus_in_multiple_sclerosis_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=19664371.ui DB - PRIME DP - Unbound Medicine ER -