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Estimation of the percolation thresholds in ternary lobenzarit disodium-dextran-HPMC hydrophilic matrices tablets: effects of initial porosity.
Eur J Pharm Sci. 2009 Nov 05; 38(4):312-9.EJ

Abstract

The aim of this work is to estimate the excipient percolation threshold for a new combined matrix native dextran (DT), series B110-1-2 (Mw 2 x 10(6)): HPMC K4M CR: lobenzarit disodium (LBD) system and demonstrate the advantages of this ternary system with respect to previously reported binary dextran:LBD and HPMC:LBD tablets. The formulations studied were prepared with different amounts of excipient (DT:HPMC, 4:1 (wt/wt) for all tablets and relative polymer/drug particle size of 4.17) in the range of 10-70% (wt/wt). Dissolution studies were carried out using the paddle method (100 rpm) and one face water uptake measurements were performed using a modified Enslin apparatus. The Higuchi's models as well as the non-linear regression were employed as empiric methods to study the released data. Values of diffusion exponent 0.588<n<0.784 (Korsmeyer equation) for dissolution profile and water uptake mechanism 0.715<n<0.960 (Davidson and Peppas equation) suggests anomalous or complex mechanisms in all cases. The critical points in ternary tablets were reduced from 44.75% (v/v) of excipient (correspond to purely native dextran) to 22.34% (v/v) (corresponding to mixture native dextran:HPMC, 4:1, wt/wt). The initial porosity (IP) of hydrophilic matrices above the values of 20% has an important influence on the percolation threshold as well as on establishment of the gel barrier responsible for the controlled release from the DT:HPMC:LBD tablets.

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Authors+Show Affiliations

Castellanos Gil E
Faculty of Pharmacy, University of Havana, Cuba. eddy02cu@yahoo.es
Iraizoz Colarte A
No affiliation info available
Bataille B
No affiliation info available
Brouillet F
No affiliation info available
Caraballo I
No affiliation info available

MeSH

DextransLactoseMethylcellulosePorosityTabletsTechnology, Pharmaceuticalortho-Aminobenzoates

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19666114

Citation

Castellanos Gil, Eddy, et al. "Estimation of the Percolation Thresholds in Ternary Lobenzarit disodium-dextran-HPMC Hydrophilic Matrices Tablets: Effects of Initial Porosity." European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences, vol. 38, no. 4, 2009, pp. 312-9.
Castellanos Gil E, Iraizoz Colarte A, Bataille B, et al. Estimation of the percolation thresholds in ternary lobenzarit disodium-dextran-HPMC hydrophilic matrices tablets: effects of initial porosity. Eur J Pharm Sci. 2009;38(4):312-9.
Castellanos Gil, E., Iraizoz Colarte, A., Bataille, B., Brouillet, F., & Caraballo, I. (2009). Estimation of the percolation thresholds in ternary lobenzarit disodium-dextran-HPMC hydrophilic matrices tablets: effects of initial porosity. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences, 38(4), 312-9. https://doi.org/10.1016/j.ejps.2009.07.013
Castellanos Gil E, et al. Estimation of the Percolation Thresholds in Ternary Lobenzarit disodium-dextran-HPMC Hydrophilic Matrices Tablets: Effects of Initial Porosity. Eur J Pharm Sci. 2009 Nov 5;38(4):312-9. PubMed PMID: 19666114.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Estimation of the percolation thresholds in ternary lobenzarit disodium-dextran-HPMC hydrophilic matrices tablets: effects of initial porosity. AU - Castellanos Gil,Eddy, AU - Iraizoz Colarte,Antonio, AU - Bataille,Bernard, AU - Brouillet,Fabien, AU - Caraballo,Isidoro, Y1 - 2009/08/08/ PY - 2007/09/13/received PY - 2009/07/13/revised PY - 2009/07/30/accepted PY - 2009/8/12/entrez PY - 2009/8/12/pubmed PY - 2010/6/4/medline SP - 312 EP - 9 JF - European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences JO - Eur J Pharm Sci VL - 38 IS - 4 N2 - The aim of this work is to estimate the excipient percolation threshold for a new combined matrix native dextran (DT), series B110-1-2 (Mw 2 x 10(6)): HPMC K4M CR: lobenzarit disodium (LBD) system and demonstrate the advantages of this ternary system with respect to previously reported binary dextran:LBD and HPMC:LBD tablets. The formulations studied were prepared with different amounts of excipient (DT:HPMC, 4:1 (wt/wt) for all tablets and relative polymer/drug particle size of 4.17) in the range of 10-70% (wt/wt). Dissolution studies were carried out using the paddle method (100 rpm) and one face water uptake measurements were performed using a modified Enslin apparatus. The Higuchi's models as well as the non-linear regression were employed as empiric methods to study the released data. Values of diffusion exponent 0.588<n<0.784 (Korsmeyer equation) for dissolution profile and water uptake mechanism 0.715<n<0.960 (Davidson and Peppas equation) suggests anomalous or complex mechanisms in all cases. The critical points in ternary tablets were reduced from 44.75% (v/v) of excipient (correspond to purely native dextran) to 22.34% (v/v) (corresponding to mixture native dextran:HPMC, 4:1, wt/wt). The initial porosity (IP) of hydrophilic matrices above the values of 20% has an important influence on the percolation threshold as well as on establishment of the gel barrier responsible for the controlled release from the DT:HPMC:LBD tablets. SN - 1879-0720 UR - https://www.unboundmedicine.com/medline/citation/19666114/Estimation_of_the_percolation_thresholds_in_ternary_lobenzarit_disodium_dextran_HPMC_hydrophilic_matrices_tablets:_effects_of_initial_porosity_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0928-0987(09)00219-X DB - PRIME DP - Unbound Medicine ER -