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Relationship of omega-3 and omega-6 fatty acids with semen characteristics, and anti-oxidant status of seminal plasma: a comparison between fertile and infertile men.
Clin Nutr 2010; 29(1):100-5CN

Abstract

BACKGROUND & AIMS

Fatty acid (FA) composition of the spermatozoa may be an important determinant of fertility. The aim was to evaluate polyunsaturated fatty acid (PUFA) composition of the blood plasma and spermatozoa in infertile men with idiopathic oligoasthenoteratozoospermia (OAT).

METHODS

Eighty-two infertile men with idiopathic OAT and seventy-eight fertile men defined according to semen concentration and proven fertility were enrolled in the study. The semen parameters were assessed according to World Health Organization criteria; three omega-3 fatty acids--alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), and two omega-6 fatty acids--linoleic acid (LA) and arachidonic acid (AA) concentrations were measured in blood plasma and spermatozoa; and the seminal plasma enzymatic antioxidant levels of catalase, and superoxide dismutase (SOD) were also assessed.

RESULTS

Proven fertile men had higher blood and spermatozoa levels of omega-3 FAs compared with the infertile patients. The ratio of serum omega-6/omega-3 fatty acids was significantly higher in infertile (14.8+/-4.3) patients compared to fertile controls (6.3+/-2.2) (P=0.001). Additionally, levels of AA were higher and the omega-3 index (EPA+DHA) was lower in infertile subjects than in fertile controls (all P values<0.05). Infertile men had higher mean AA:DHA ratio and AA:EPA (6.4+/-2.9 and 12.0+/-4.9, respectively) than fertile men (3.3+/-1.8 and 6.7+/-2.6, respectively) (both P=0.001). A strong negative correlation was found between the AA:DHA and AA:EPA ratios and total sperm count (r=-0.62, P=0.001 and r=-0.64, P=0.001, respectively), sperm motility (r=-0.63, P=0.001 and r=-0.61, P=0.001, respectively), and sperm morphology (r=-0.61, P=0.001, and r=-0.59, P=0.002, respectively).

CONCLUSIONS

Infertile men had lower concentrations of omega-3 FAs in spermatozoa than fertile men. These results suggest that research should be performed to assess the potential benefits of omega-3 FA supplementation as a therapeutic approach in infertile men with idiopathic OAT.

Authors+Show Affiliations

Urology and Nephrology Research Center, Department of Urology, Shahid Modarress Hospital, Shahid Beheshti University (MC), Tehran, Iran. safarinejad@unrc.irNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

19666200

Citation

Safarinejad, Mohammad Reza, et al. "Relationship of Omega-3 and Omega-6 Fatty Acids With Semen Characteristics, and Anti-oxidant Status of Seminal Plasma: a Comparison Between Fertile and Infertile Men." Clinical Nutrition (Edinburgh, Scotland), vol. 29, no. 1, 2010, pp. 100-5.
Safarinejad MR, Hosseini SY, Dadkhah F, et al. Relationship of omega-3 and omega-6 fatty acids with semen characteristics, and anti-oxidant status of seminal plasma: a comparison between fertile and infertile men. Clin Nutr. 2010;29(1):100-5.
Safarinejad, M. R., Hosseini, S. Y., Dadkhah, F., & Asgari, M. A. (2010). Relationship of omega-3 and omega-6 fatty acids with semen characteristics, and anti-oxidant status of seminal plasma: a comparison between fertile and infertile men. Clinical Nutrition (Edinburgh, Scotland), 29(1), pp. 100-5. doi:10.1016/j.clnu.2009.07.008.
Safarinejad MR, et al. Relationship of Omega-3 and Omega-6 Fatty Acids With Semen Characteristics, and Anti-oxidant Status of Seminal Plasma: a Comparison Between Fertile and Infertile Men. Clin Nutr. 2010;29(1):100-5. PubMed PMID: 19666200.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship of omega-3 and omega-6 fatty acids with semen characteristics, and anti-oxidant status of seminal plasma: a comparison between fertile and infertile men. AU - Safarinejad,Mohammad Reza, AU - Hosseini,Seyyed Yousof, AU - Dadkhah,Farid, AU - Asgari,Majid Ali, Y1 - 2009/08/08/ PY - 2009/02/25/received PY - 2009/06/28/revised PY - 2009/07/16/accepted PY - 2009/8/12/entrez PY - 2009/8/12/pubmed PY - 2010/5/13/medline SP - 100 EP - 5 JF - Clinical nutrition (Edinburgh, Scotland) JO - Clin Nutr VL - 29 IS - 1 N2 - BACKGROUND & AIMS: Fatty acid (FA) composition of the spermatozoa may be an important determinant of fertility. The aim was to evaluate polyunsaturated fatty acid (PUFA) composition of the blood plasma and spermatozoa in infertile men with idiopathic oligoasthenoteratozoospermia (OAT). METHODS: Eighty-two infertile men with idiopathic OAT and seventy-eight fertile men defined according to semen concentration and proven fertility were enrolled in the study. The semen parameters were assessed according to World Health Organization criteria; three omega-3 fatty acids--alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), and two omega-6 fatty acids--linoleic acid (LA) and arachidonic acid (AA) concentrations were measured in blood plasma and spermatozoa; and the seminal plasma enzymatic antioxidant levels of catalase, and superoxide dismutase (SOD) were also assessed. RESULTS: Proven fertile men had higher blood and spermatozoa levels of omega-3 FAs compared with the infertile patients. The ratio of serum omega-6/omega-3 fatty acids was significantly higher in infertile (14.8+/-4.3) patients compared to fertile controls (6.3+/-2.2) (P=0.001). Additionally, levels of AA were higher and the omega-3 index (EPA+DHA) was lower in infertile subjects than in fertile controls (all P values<0.05). Infertile men had higher mean AA:DHA ratio and AA:EPA (6.4+/-2.9 and 12.0+/-4.9, respectively) than fertile men (3.3+/-1.8 and 6.7+/-2.6, respectively) (both P=0.001). A strong negative correlation was found between the AA:DHA and AA:EPA ratios and total sperm count (r=-0.62, P=0.001 and r=-0.64, P=0.001, respectively), sperm motility (r=-0.63, P=0.001 and r=-0.61, P=0.001, respectively), and sperm morphology (r=-0.61, P=0.001, and r=-0.59, P=0.002, respectively). CONCLUSIONS: Infertile men had lower concentrations of omega-3 FAs in spermatozoa than fertile men. These results suggest that research should be performed to assess the potential benefits of omega-3 FA supplementation as a therapeutic approach in infertile men with idiopathic OAT. SN - 1532-1983 UR - https://www.unboundmedicine.com/medline/citation/19666200/Relationship_of_omega_3_and_omega_6_fatty_acids_with_semen_characteristics_and_anti_oxidant_status_of_seminal_plasma:_a_comparison_between_fertile_and_infertile_men_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0261-5614(09)00158-7 DB - PRIME DP - Unbound Medicine ER -