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[Blood parameters variation in Calomys musculinus infected with Junin virus, strain XJCl3].
Medicina (B Aires). 1990; 50(4):335-42.M

Abstract

The aim of this study was to analyze the alterations in homeostasis induced by Junin virus during acute and persistent infection of C. musculinus. Virus presence in brain, hematological response and glycemia levels were evaluated. Newborn C. musculinus inoculated with 4000 DL50 of Junin virus, strain XJCl3 by intraperitoneal route developed a typical acute disease, with 50-70% mortality. Virus was isolated from brain starting day 6 post-infection (Fig. 1) and the peak titer (10(8) DL50/ml) was reached at 12 days post-infection. Neutralizing anti-Junin virus antibodies were detected from day 11 post-infection and all chronically infected animals developed persistent levels of neutralizing antibodies. In the acute stage of infection, 40% of the animals developed lymphopenia and neutrophilia (Fig. 2) while a slight variation was observed in the monocyte population. An important hypoglycemia was also seen in the acute infection (mean = 3.52 mmol/l) in comparison with control values (mean = 6.21 mmol/l), p less than 0.01 (Fig. 3). By contrast during the chronic stage of infection, neither hematological parameters (Table 2) varied between infected and control animals.

Authors+Show Affiliations

Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

spa

PubMed ID

1966622

Citation

Steyerthal, N L., et al. "[Blood Parameters Variation in Calomys Musculinus Infected With Junin Virus, Strain XJCl3]." Medicina, vol. 50, no. 4, 1990, pp. 335-42.
Steyerthal NL, Lampuri JS, Coto CE. [Blood parameters variation in Calomys musculinus infected with Junin virus, strain XJCl3]. Medicina (B Aires). 1990;50(4):335-42.
Steyerthal, N. L., Lampuri, J. S., & Coto, C. E. (1990). [Blood parameters variation in Calomys musculinus infected with Junin virus, strain XJCl3]. Medicina, 50(4), 335-42.
Steyerthal NL, Lampuri JS, Coto CE. [Blood Parameters Variation in Calomys Musculinus Infected With Junin Virus, Strain XJCl3]. Medicina (B Aires). 1990;50(4):335-42. PubMed PMID: 1966622.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Blood parameters variation in Calomys musculinus infected with Junin virus, strain XJCl3]. AU - Steyerthal,N L, AU - Lampuri,J S, AU - Coto,C E, PY - 1990/1/1/pubmed PY - 1990/1/1/medline PY - 1990/1/1/entrez SP - 335 EP - 42 JF - Medicina JO - Medicina (B Aires) VL - 50 IS - 4 N2 - The aim of this study was to analyze the alterations in homeostasis induced by Junin virus during acute and persistent infection of C. musculinus. Virus presence in brain, hematological response and glycemia levels were evaluated. Newborn C. musculinus inoculated with 4000 DL50 of Junin virus, strain XJCl3 by intraperitoneal route developed a typical acute disease, with 50-70% mortality. Virus was isolated from brain starting day 6 post-infection (Fig. 1) and the peak titer (10(8) DL50/ml) was reached at 12 days post-infection. Neutralizing anti-Junin virus antibodies were detected from day 11 post-infection and all chronically infected animals developed persistent levels of neutralizing antibodies. In the acute stage of infection, 40% of the animals developed lymphopenia and neutrophilia (Fig. 2) while a slight variation was observed in the monocyte population. An important hypoglycemia was also seen in the acute infection (mean = 3.52 mmol/l) in comparison with control values (mean = 6.21 mmol/l), p less than 0.01 (Fig. 3). By contrast during the chronic stage of infection, neither hematological parameters (Table 2) varied between infected and control animals. SN - 0025-7680 UR - https://www.unboundmedicine.com/medline/citation/1966622/[Blood_parameters_variation_in_Calomys_musculinus_infected_with_Junin_virus_strain_XJCl3]_ DB - PRIME DP - Unbound Medicine ER -