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Living-related liver transplantation in patients with variceal bleeding: outcome and prognostic factors.
Hepatobiliary Pancreat Dis Int. 2009 Aug; 8(4):358-62.HP

Abstract

BACKGROUND

Liver transplantation currently represents the ultimate therapy for bleeding esophageal varices in patients with liver cirrhosis. It is the only therapy that cures both portal hypertension and the underlying liver disease. The outcome of liver transplantation is thought to be correlated with several factors. In this study, the clinical outcome of living-related liver transplantation (LRLT) was evaluated in patients with variceal bleeding, and the prognostic indicators of short-term survival in these patients were identified.

METHODS

We reviewed retrospectively 121 patients with a history of variceal bleeding who had received LRLT from 1998 to 2006. The clinical outcomes were analyzed, and the risk factors for short-term survival were defined.

RESULTS

The 3-month survival rate of patients with variceal bleeding was 83.4%, while that of non-bleeders was 87%. Sepsis was the commonest cause of death in both groups. Portal vein diameter and blood transfusion were the only independent prognostic factors for short-term survival among variceal bleeders.

CONCLUSION

The outcome of LRLT in recipients with variceal bleeding is based on the improvement of portal hemodynamics, by minimizing intraoperative blood loss and subsequent blood transfusion.

Authors+Show Affiliations

Department of Hepato-Biliary-Pancreatic and Transplant Surgery, Kyoto University, Japan. hedayamsm@yahoo.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19666403

Citation

Hedaya, Mohammed Saied, et al. "Living-related Liver Transplantation in Patients With Variceal Bleeding: Outcome and Prognostic Factors." Hepatobiliary & Pancreatic Diseases International : HBPD INT, vol. 8, no. 4, 2009, pp. 358-62.
Hedaya MS, El Moghazy WM, Uemoto S. Living-related liver transplantation in patients with variceal bleeding: outcome and prognostic factors. Hepatobiliary Pancreat Dis Int. 2009;8(4):358-62.
Hedaya, M. S., El Moghazy, W. M., & Uemoto, S. (2009). Living-related liver transplantation in patients with variceal bleeding: outcome and prognostic factors. Hepatobiliary & Pancreatic Diseases International : HBPD INT, 8(4), 358-62.
Hedaya MS, El Moghazy WM, Uemoto S. Living-related Liver Transplantation in Patients With Variceal Bleeding: Outcome and Prognostic Factors. Hepatobiliary Pancreat Dis Int. 2009;8(4):358-62. PubMed PMID: 19666403.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Living-related liver transplantation in patients with variceal bleeding: outcome and prognostic factors. AU - Hedaya,Mohammed Saied, AU - El Moghazy,Walid Mohamed, AU - Uemoto,Shinji, PY - 2009/8/12/entrez PY - 2009/8/12/pubmed PY - 2010/1/20/medline SP - 358 EP - 62 JF - Hepatobiliary & pancreatic diseases international : HBPD INT JO - Hepatobiliary Pancreat Dis Int VL - 8 IS - 4 N2 - BACKGROUND: Liver transplantation currently represents the ultimate therapy for bleeding esophageal varices in patients with liver cirrhosis. It is the only therapy that cures both portal hypertension and the underlying liver disease. The outcome of liver transplantation is thought to be correlated with several factors. In this study, the clinical outcome of living-related liver transplantation (LRLT) was evaluated in patients with variceal bleeding, and the prognostic indicators of short-term survival in these patients were identified. METHODS: We reviewed retrospectively 121 patients with a history of variceal bleeding who had received LRLT from 1998 to 2006. The clinical outcomes were analyzed, and the risk factors for short-term survival were defined. RESULTS: The 3-month survival rate of patients with variceal bleeding was 83.4%, while that of non-bleeders was 87%. Sepsis was the commonest cause of death in both groups. Portal vein diameter and blood transfusion were the only independent prognostic factors for short-term survival among variceal bleeders. CONCLUSION: The outcome of LRLT in recipients with variceal bleeding is based on the improvement of portal hemodynamics, by minimizing intraoperative blood loss and subsequent blood transfusion. SN - 1499-3872 UR - https://www.unboundmedicine.com/medline/citation/19666403/Living_related_liver_transplantation_in_patients_with_variceal_bleeding:_outcome_and_prognostic_factors_ L2 - http://www.diseaseinfosearch.org/result/7171 DB - PRIME DP - Unbound Medicine ER -