Tags

Type your tag names separated by a space and hit enter

Affect of seizures during gestation on pregnancy outcomes in women with epilepsy.
Arch Neurol. 2009 Aug; 66(8):979-84.AN

Abstract

OBJECTIVE

To assess whether seizures in women with epilepsy during pregnancy contribute to adverse pregnancy outcomes.

DESIGN

A retrospective cross-sectional study.

SETTING

Taiwan. Patients This study linked 2 nationwide population-based data sets: Taiwan's birth certificate registry and the Taiwan National Health Insurance Research Data set. A total of 1016 women with epilepsy were selected who had single births from 2001 to 2003 and who had been diagnosed with epilepsy within 2 years prior to their index delivery, together with 8128 matched women without chronic disease as a comparison cohort. Women with epilepsy were further stratified into 2 groups for analysis: women who did and did not have seizures during pregnancy.

MAIN OUTCOME MEASURES

Low-birth-weight infants, preterm delivery, and infants who are small for gestational age (SGA).

RESULTS

Compared with women without epilepsy, epileptic seizures during pregnancy were independently associated with a 1.36-fold (95% confidence interval [CI], 1.01-1.88), 1.63-fold (95% CI, 1.21-2.19), and 1.37-fold (95% CI, 1.09-1.70) increased risk of low-birth-weight infants, preterm delivery, and SGA, respectively, after adjusting for family income and parental and infant characteristics. Further, the risk of SGA increased significantly (odds ratio, 1.34; 95% CI, 1.01-1.84) for women with seizures during pregnancy compared with women with epilepsy who did not have seizures during pregnancy.

CONCLUSION

We suggest preventing seizures during pregnancy as an essential step to reduce risk of adverse pregnancy outcomes.

Authors+Show Affiliations

School of Public Health, Taipei Medical University, Taipei, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19667219

Citation

Chen, Yi-Hua, et al. "Affect of Seizures During Gestation On Pregnancy Outcomes in Women With Epilepsy." Archives of Neurology, vol. 66, no. 8, 2009, pp. 979-84.
Chen YH, Chiou HY, Lin HC, et al. Affect of seizures during gestation on pregnancy outcomes in women with epilepsy. Arch Neurol. 2009;66(8):979-84.
Chen, Y. H., Chiou, H. Y., Lin, H. C., & Lin, H. L. (2009). Affect of seizures during gestation on pregnancy outcomes in women with epilepsy. Archives of Neurology, 66(8), 979-84. https://doi.org/10.1001/archneurol.2009.142
Chen YH, et al. Affect of Seizures During Gestation On Pregnancy Outcomes in Women With Epilepsy. Arch Neurol. 2009;66(8):979-84. PubMed PMID: 19667219.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Affect of seizures during gestation on pregnancy outcomes in women with epilepsy. AU - Chen,Yi-Hua, AU - Chiou,Hung-Yi, AU - Lin,Herng-Ching, AU - Lin,Hsiu-Li, PY - 2009/8/12/entrez PY - 2009/8/12/pubmed PY - 2009/8/21/medline SP - 979 EP - 84 JF - Archives of neurology JO - Arch Neurol VL - 66 IS - 8 N2 - OBJECTIVE: To assess whether seizures in women with epilepsy during pregnancy contribute to adverse pregnancy outcomes. DESIGN: A retrospective cross-sectional study. SETTING: Taiwan. Patients This study linked 2 nationwide population-based data sets: Taiwan's birth certificate registry and the Taiwan National Health Insurance Research Data set. A total of 1016 women with epilepsy were selected who had single births from 2001 to 2003 and who had been diagnosed with epilepsy within 2 years prior to their index delivery, together with 8128 matched women without chronic disease as a comparison cohort. Women with epilepsy were further stratified into 2 groups for analysis: women who did and did not have seizures during pregnancy. MAIN OUTCOME MEASURES: Low-birth-weight infants, preterm delivery, and infants who are small for gestational age (SGA). RESULTS: Compared with women without epilepsy, epileptic seizures during pregnancy were independently associated with a 1.36-fold (95% confidence interval [CI], 1.01-1.88), 1.63-fold (95% CI, 1.21-2.19), and 1.37-fold (95% CI, 1.09-1.70) increased risk of low-birth-weight infants, preterm delivery, and SGA, respectively, after adjusting for family income and parental and infant characteristics. Further, the risk of SGA increased significantly (odds ratio, 1.34; 95% CI, 1.01-1.84) for women with seizures during pregnancy compared with women with epilepsy who did not have seizures during pregnancy. CONCLUSION: We suggest preventing seizures during pregnancy as an essential step to reduce risk of adverse pregnancy outcomes. SN - 1538-3687 UR - https://www.unboundmedicine.com/medline/citation/19667219/Affect_of_seizures_during_gestation_on_pregnancy_outcomes_in_women_with_epilepsy_ L2 - https://jamanetwork.com/journals/jamaneurology/fullarticle/10.1001/archneurol.2009.142 DB - PRIME DP - Unbound Medicine ER -