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Infections of the upper respiratory tract, head, and neck. The role of anaerobic bacteria.
Postgrad Med. 2000 Dec; 108(7 Suppl Contemporaty):37-48.PM

Abstract

Anaerobic bacteria predominate in the normal flora of the human oropharynx and therefore are a common cause of endogenous bacterial infections of the upper respiratory tract. They are found in chronic otitis media and sinusitis, play a pathogenic role in tonsillitis, and are important contributors to complications of these infections. Anaerobes also predominate in deep oral and neck infections and abscesses. Their direct pathogenicity in these infections is compounded by their ability to produce beta-lactamase, which allows anaerobes to "shield" non-beta-lactamase-producing bacteria from penicillin activity. Their slow growth, polymicrobial nature, and growing resistance to antimicrobial agents complicate treatment. Usually, antimicrobial therapy is all that is needed, but in some cases, it serves as an important adjunct to surgical intervention. Adequate antimicrobial coverage of both anaerobic and aerobic bacteria is essential because culture usually reveals a mixed infection. Failure to select the appropriate antibiotics may lead to clinical failure.

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Publisher Full Text

Authors+Show Affiliations

Brook I
Georgetown University School of Medicine, Washington, DC 20016, USA. brook@mx.afrri.usuhs.mil

MeSH

AminoglycosidesAnti-Bacterial AgentsBacteria, AnaerobicBacterial InfectionsFluoroquinolonesHumansRespiratory Tract InfectionsRisk FactorsTetracyclinebeta-Lactams

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19667548

Citation

Brook, I. "Infections of the Upper Respiratory Tract, Head, and Neck. the Role of Anaerobic Bacteria." Postgraduate Medicine, vol. 108, no. 7 Suppl Contemporaty, 2000, pp. 37-48.
Brook I. Infections of the upper respiratory tract, head, and neck. The role of anaerobic bacteria. Postgrad Med. 2000;108(7 Suppl Contemporaty):37-48.
Brook, I. (2000). Infections of the upper respiratory tract, head, and neck. The role of anaerobic bacteria. Postgraduate Medicine, 108(7 Suppl Contemporaty), 37-48. https://doi.org/10.3810/pgm.12.2000.suppl10.55
Brook I. Infections of the Upper Respiratory Tract, Head, and Neck. the Role of Anaerobic Bacteria. Postgrad Med. 2000;108(7 Suppl Contemporaty):37-48. PubMed PMID: 19667548.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Infections of the upper respiratory tract, head, and neck. The role of anaerobic bacteria. A1 - Brook,I, PY - 2009/8/12/entrez PY - 2000/12/1/pubmed PY - 2009/9/15/medline SP - 37 EP - 48 JF - Postgraduate medicine JO - Postgrad Med VL - 108 IS - 7 Suppl Contemporaty N2 - Anaerobic bacteria predominate in the normal flora of the human oropharynx and therefore are a common cause of endogenous bacterial infections of the upper respiratory tract. They are found in chronic otitis media and sinusitis, play a pathogenic role in tonsillitis, and are important contributors to complications of these infections. Anaerobes also predominate in deep oral and neck infections and abscesses. Their direct pathogenicity in these infections is compounded by their ability to produce beta-lactamase, which allows anaerobes to "shield" non-beta-lactamase-producing bacteria from penicillin activity. Their slow growth, polymicrobial nature, and growing resistance to antimicrobial agents complicate treatment. Usually, antimicrobial therapy is all that is needed, but in some cases, it serves as an important adjunct to surgical intervention. Adequate antimicrobial coverage of both anaerobic and aerobic bacteria is essential because culture usually reveals a mixed infection. Failure to select the appropriate antibiotics may lead to clinical failure. SN - 1941-9260 UR - https://www.unboundmedicine.com/medline/citation/19667548/Infections_of_the_upper_respiratory_tract_head_and_neck__The_role_of_anaerobic_bacteria_ L2 - https://www.tandfonline.com/doi/full/10.3810/pgm.12.2000.suppl10.55 DB - PRIME DP - Unbound Medicine ER -