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Association of obesity and atrial fibrillation among middle-aged and elderly Chinese.
Int J Obes (Lond) 2009; 33(11):1318-25IJ

Abstract

OBJECTIVE

To examine the associations between body mass index (BMI), waist circumference (WC) and risk of atrial fibrillation (AF) in Chinese adults.

DESIGN, SUBJECTS AND MEASUREMENTS

A cross-sectional study was conducted to explore the association between obesity and atrial fibrillation among 18,615 Chinese (10,370 females) aged 35 years and above in 2004. AF was defined by electrocardiography and history. Obesity was classified by BMI and WC, including overweight (BMI: 24.0-27.9 kg m(-2); WC: 85.0-94.9 cm for men and 80.0-89.9 cm for women) and obesity (BMI: > or = 28.0 kg m(-2); WC: > or = 95 cm for men and > or = 90 cm for women), according to the Chinese Guidelines on Prevention and Treatment of Obesity in Adults. Multivariable logistic regression was used to analyze the association between obesity and AF.

RESULTS

Age- and sex-adjusted prevalence of AF (n=194) was higher with increased BMI, with 0.9% for normal, 1.1% for overweight and 1.6% for obese (P(trend)<0.01) Chinese. Compared with normal BMI, multivariable-adjusted odds ratios (ORs) were 1.2 (95% confidence interval (CI): 0.8-1.7) for overweight BMI and 1.8 (95% CI: 1.2-2.8) for obese BMI (P(trend)<0.01). After excluding known secondary AF (valvular, postoperative and hyperthyroid) and unclassified AF, the corresponding multivariable-adjusted ORs were 1.4 (95% CI: 0.9-2.2) and 2.2 (95% CI: 1.3-3.7) (P (trend)<0.01). The same trends were observed for WC. Multivariable-adjusted OR was 2.6 (95% CI: 1.4-4.6) for participants with both BMI and WC obesity and 1.7 (95% CI: 1.0-2.9) for participants with both BMI and WC overweight in comparison with those with both BMI and WC in the normal range.

CONCLUSION

Obesity, either defined by BMI or WC, was significantly associated with AF among middle-aged and elderly Chinese.

Authors+Show Affiliations

Science and Education Division, Beijing Municipal Health Bureau, Beijing, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19668255

Citation

Zhang, X, et al. "Association of Obesity and Atrial Fibrillation Among Middle-aged and Elderly Chinese." International Journal of Obesity (2005), vol. 33, no. 11, 2009, pp. 1318-25.
Zhang X, Zhang S, Li Y, et al. Association of obesity and atrial fibrillation among middle-aged and elderly Chinese. Int J Obes (Lond). 2009;33(11):1318-25.
Zhang, X., Zhang, S., Li, Y., Detrano, R. C., Chen, K., Li, X., ... Wu, Y. (2009). Association of obesity and atrial fibrillation among middle-aged and elderly Chinese. International Journal of Obesity (2005), 33(11), pp. 1318-25. doi:10.1038/ijo.2009.157.
Zhang X, et al. Association of Obesity and Atrial Fibrillation Among Middle-aged and Elderly Chinese. Int J Obes (Lond). 2009;33(11):1318-25. PubMed PMID: 19668255.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of obesity and atrial fibrillation among middle-aged and elderly Chinese. AU - Zhang,X, AU - Zhang,S, AU - Li,Y, AU - Detrano,R C, AU - Chen,K, AU - Li,X, AU - Zhao,L, AU - Benjamin,E J, AU - Wu,Y, Y1 - 2009/08/11/ PY - 2009/8/12/entrez PY - 2009/8/12/pubmed PY - 2010/10/22/medline SP - 1318 EP - 25 JF - International journal of obesity (2005) JO - Int J Obes (Lond) VL - 33 IS - 11 N2 - OBJECTIVE: To examine the associations between body mass index (BMI), waist circumference (WC) and risk of atrial fibrillation (AF) in Chinese adults. DESIGN, SUBJECTS AND MEASUREMENTS: A cross-sectional study was conducted to explore the association between obesity and atrial fibrillation among 18,615 Chinese (10,370 females) aged 35 years and above in 2004. AF was defined by electrocardiography and history. Obesity was classified by BMI and WC, including overweight (BMI: 24.0-27.9 kg m(-2); WC: 85.0-94.9 cm for men and 80.0-89.9 cm for women) and obesity (BMI: > or = 28.0 kg m(-2); WC: > or = 95 cm for men and > or = 90 cm for women), according to the Chinese Guidelines on Prevention and Treatment of Obesity in Adults. Multivariable logistic regression was used to analyze the association between obesity and AF. RESULTS: Age- and sex-adjusted prevalence of AF (n=194) was higher with increased BMI, with 0.9% for normal, 1.1% for overweight and 1.6% for obese (P(trend)<0.01) Chinese. Compared with normal BMI, multivariable-adjusted odds ratios (ORs) were 1.2 (95% confidence interval (CI): 0.8-1.7) for overweight BMI and 1.8 (95% CI: 1.2-2.8) for obese BMI (P(trend)<0.01). After excluding known secondary AF (valvular, postoperative and hyperthyroid) and unclassified AF, the corresponding multivariable-adjusted ORs were 1.4 (95% CI: 0.9-2.2) and 2.2 (95% CI: 1.3-3.7) (P (trend)<0.01). The same trends were observed for WC. Multivariable-adjusted OR was 2.6 (95% CI: 1.4-4.6) for participants with both BMI and WC obesity and 1.7 (95% CI: 1.0-2.9) for participants with both BMI and WC overweight in comparison with those with both BMI and WC in the normal range. CONCLUSION: Obesity, either defined by BMI or WC, was significantly associated with AF among middle-aged and elderly Chinese. SN - 1476-5497 UR - https://www.unboundmedicine.com/medline/citation/19668255/Association_of_obesity_and_atrial_fibrillation_among_middle_aged_and_elderly_Chinese_ L2 - http://dx.doi.org/10.1038/ijo.2009.157 DB - PRIME DP - Unbound Medicine ER -