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Decreased dendritic spine density of neurons of the prefrontal cortex and nucleus accumbens and enhanced amphetamine sensitivity in postpubertal rats after a neonatal amygdala lesion.
Synapse. 2009 Dec; 63(12):1143-53.S

Abstract

A neonatal basolateral-amygdala (nBLA) lesion in rats could be a potential animal model to study the early neurodevelopmental abnormalities associated with the behavioral and morphological brain changes observed in schizophrenia. Morphological alterations in pyramidal neurons from the prefrontal cortex (PFC) have been observed in postmortem schizophrenic brains, mainly because of decreased dendritic arbor and spine density. We assessed the effects of nBLA-lesion on the dendritic morphology of neurons from the PFC and the nucleus accumbens (NAcc) in rats. nBLA lesions were made on postnatal day 7 (PD7), and later, the dendritic morphology was studied by the Golgi-Cox stain procedure followed by Sholl analysis at PD35 (prepubertal) and PD60 (adult) ages. We also evaluated the effects of the nBLA-lesion on locomotor activity caused by a novel environment, apomorphine, and amphetamine. Adult animals with nBLA lesions showed a decreased spine density in pyramidal neurons from the PFC and in medium spiny cells from the NAcc. An increased locomotion in a novel environment and in amphetamine-treated adult animals with an nBLA-lesion was observed. Our results indicate that nBLA-lesion alters the neuronal dendrite morphology of the NAcc and PFC, suggesting a disconnection between these limbic structures. The locomotion paradigms support the idea that dopaminergic transmission is altered in the nBLA lesion model. This could help to understand the consequences of an earlier amygdala dysfunction in schizophrenia.

Authors+Show Affiliations

Laboratorio de Neuropsiquiatría, Instituto de Fisiología, Universidad Autónoma de Puebla. 14 Sur 6301, CP: 72570, Puebla, México.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19670311

Citation

Solis, Oscar, et al. "Decreased Dendritic Spine Density of Neurons of the Prefrontal Cortex and Nucleus Accumbens and Enhanced Amphetamine Sensitivity in Postpubertal Rats After a Neonatal Amygdala Lesion." Synapse (New York, N.Y.), vol. 63, no. 12, 2009, pp. 1143-53.
Solis O, Vázquez-Roque RA, Camacho-Abrego I, et al. Decreased dendritic spine density of neurons of the prefrontal cortex and nucleus accumbens and enhanced amphetamine sensitivity in postpubertal rats after a neonatal amygdala lesion. Synapse. 2009;63(12):1143-53.
Solis, O., Vázquez-Roque, R. A., Camacho-Abrego, I., Gamboa, C., De La Cruz, F., Zamudio, S., & Flores, G. (2009). Decreased dendritic spine density of neurons of the prefrontal cortex and nucleus accumbens and enhanced amphetamine sensitivity in postpubertal rats after a neonatal amygdala lesion. Synapse (New York, N.Y.), 63(12), 1143-53. https://doi.org/10.1002/syn.20697
Solis O, et al. Decreased Dendritic Spine Density of Neurons of the Prefrontal Cortex and Nucleus Accumbens and Enhanced Amphetamine Sensitivity in Postpubertal Rats After a Neonatal Amygdala Lesion. Synapse. 2009;63(12):1143-53. PubMed PMID: 19670311.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Decreased dendritic spine density of neurons of the prefrontal cortex and nucleus accumbens and enhanced amphetamine sensitivity in postpubertal rats after a neonatal amygdala lesion. AU - Solis,Oscar, AU - Vázquez-Roque,Rubén Antonio, AU - Camacho-Abrego,Israel, AU - Gamboa,Citlalli, AU - De La Cruz,Fidel, AU - Zamudio,Sergio, AU - Flores,Gonzalo, PY - 2009/8/12/entrez PY - 2009/8/12/pubmed PY - 2010/2/18/medline SP - 1143 EP - 53 JF - Synapse (New York, N.Y.) JO - Synapse VL - 63 IS - 12 N2 - A neonatal basolateral-amygdala (nBLA) lesion in rats could be a potential animal model to study the early neurodevelopmental abnormalities associated with the behavioral and morphological brain changes observed in schizophrenia. Morphological alterations in pyramidal neurons from the prefrontal cortex (PFC) have been observed in postmortem schizophrenic brains, mainly because of decreased dendritic arbor and spine density. We assessed the effects of nBLA-lesion on the dendritic morphology of neurons from the PFC and the nucleus accumbens (NAcc) in rats. nBLA lesions were made on postnatal day 7 (PD7), and later, the dendritic morphology was studied by the Golgi-Cox stain procedure followed by Sholl analysis at PD35 (prepubertal) and PD60 (adult) ages. We also evaluated the effects of the nBLA-lesion on locomotor activity caused by a novel environment, apomorphine, and amphetamine. Adult animals with nBLA lesions showed a decreased spine density in pyramidal neurons from the PFC and in medium spiny cells from the NAcc. An increased locomotion in a novel environment and in amphetamine-treated adult animals with an nBLA-lesion was observed. Our results indicate that nBLA-lesion alters the neuronal dendrite morphology of the NAcc and PFC, suggesting a disconnection between these limbic structures. The locomotion paradigms support the idea that dopaminergic transmission is altered in the nBLA lesion model. This could help to understand the consequences of an earlier amygdala dysfunction in schizophrenia. SN - 1098-2396 UR - https://www.unboundmedicine.com/medline/citation/19670311/Decreased_dendritic_spine_density_of_neurons_of_the_prefrontal_cortex_and_nucleus_accumbens_and_enhanced_amphetamine_sensitivity_in_postpubertal_rats_after_a_neonatal_amygdala_lesion_ L2 - https://doi.org/10.1002/syn.20697 DB - PRIME DP - Unbound Medicine ER -