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Mild cognitive impairment in rapid eye movement sleep behavior disorder and Parkinson's disease.
Ann Neurol. 2009 Jul; 66(1):39-47.AN

Abstract

OBJECTIVE

To investigate the frequency and subtypes of mild cognitive impairment (MCI) in idiopathic rapid eye movement sleep behavior disorder (RBD) and Parkinson's disease (PD) in association with RBD.

METHODS

One hundred and twelve subjects without dementia or major depression including 32 idiopathic RBD patients, 22 PD patients with polysomnography-confirmed RBD, 18 PD patients without RBD, and 40 healthy control subjects, underwent a comprehensive neuropsychological evaluation. We compared the proportion of patients with MCI between groups using standard diagnostic criteria.

RESULTS

MCI was found in 50% of idiopathic RBD patients and 73% of PD patients with RBD. In contrast, only 11% of PD patients without RBD and 8% of control subjects had MCI. The presence of MCI was significantly greater in idiopathic RBD patients and PD patients with RBD than in PD patients without RBD and control subjects. PD patients with RBD also performed worse than idiopathic RBD patients on neuropsychological tests assessing visuoconstructional and visuoperceptual abilities.

INTERPRETATION

In both its association with PD and its idiopathic form, RBD is an important risk factor for MCI. Except for visuoconstructional and visuoperceptual problems, RBD may be an important determinant of cognitive impairment in PD. Ann Neurol 2009;66:39-47.

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Authors+Show Affiliations

Gagnon JF
Centre d'étude du Sommeil et des Rythmes Biologiques, Hôpital du Sacré-Coeur de Montréal, Montréal, Québec, Canada. jean-francois.gagnon.5@umontreal.ca
Vendette M
No affiliation info available
Postuma RB
No affiliation info available
Desjardins C
No affiliation info available
Massicotte-Marquez J
No affiliation info available
Panisset M
No affiliation info available
Montplaisir J
No affiliation info available

MeSH

AdultAgedAged, 80 and overCognition DisordersElectroencephalographyFemaleHumansMaleMiddle AgedNeuropsychological TestsParkinson DiseasePsychiatric Status Rating ScalesREM Sleep Behavior DisorderSeverity of Illness IndexStatistics, Nonparametric

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19670440

Citation

Gagnon, Jean-François, et al. "Mild Cognitive Impairment in Rapid Eye Movement Sleep Behavior Disorder and Parkinson's Disease." Annals of Neurology, vol. 66, no. 1, 2009, pp. 39-47.
Gagnon JF, Vendette M, Postuma RB, et al. Mild cognitive impairment in rapid eye movement sleep behavior disorder and Parkinson's disease. Ann Neurol. 2009;66(1):39-47.
Gagnon, J. F., Vendette, M., Postuma, R. B., Desjardins, C., Massicotte-Marquez, J., Panisset, M., & Montplaisir, J. (2009). Mild cognitive impairment in rapid eye movement sleep behavior disorder and Parkinson's disease. Annals of Neurology, 66(1), 39-47. https://doi.org/10.1002/ana.21680
Gagnon JF, et al. Mild Cognitive Impairment in Rapid Eye Movement Sleep Behavior Disorder and Parkinson's Disease. Ann Neurol. 2009;66(1):39-47. PubMed PMID: 19670440.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mild cognitive impairment in rapid eye movement sleep behavior disorder and Parkinson's disease. AU - Gagnon,Jean-François, AU - Vendette,Mélanie, AU - Postuma,Ronald B, AU - Desjardins,Catherine, AU - Massicotte-Marquez,Jessica, AU - Panisset,Michel, AU - Montplaisir,Jacques, PY - 2009/8/12/entrez PY - 2009/8/12/pubmed PY - 2009/9/5/medline SP - 39 EP - 47 JF - Annals of neurology JO - Ann Neurol VL - 66 IS - 1 N2 - OBJECTIVE: To investigate the frequency and subtypes of mild cognitive impairment (MCI) in idiopathic rapid eye movement sleep behavior disorder (RBD) and Parkinson's disease (PD) in association with RBD. METHODS: One hundred and twelve subjects without dementia or major depression including 32 idiopathic RBD patients, 22 PD patients with polysomnography-confirmed RBD, 18 PD patients without RBD, and 40 healthy control subjects, underwent a comprehensive neuropsychological evaluation. We compared the proportion of patients with MCI between groups using standard diagnostic criteria. RESULTS: MCI was found in 50% of idiopathic RBD patients and 73% of PD patients with RBD. In contrast, only 11% of PD patients without RBD and 8% of control subjects had MCI. The presence of MCI was significantly greater in idiopathic RBD patients and PD patients with RBD than in PD patients without RBD and control subjects. PD patients with RBD also performed worse than idiopathic RBD patients on neuropsychological tests assessing visuoconstructional and visuoperceptual abilities. INTERPRETATION: In both its association with PD and its idiopathic form, RBD is an important risk factor for MCI. Except for visuoconstructional and visuoperceptual problems, RBD may be an important determinant of cognitive impairment in PD. Ann Neurol 2009;66:39-47. SN - 1531-8249 UR - https://www.unboundmedicine.com/medline/citation/19670440/Mild_cognitive_impairment_in_rapid_eye_movement_sleep_behavior_disorder_and_Parkinson's_disease_ L2 - https://doi.org/10.1002/ana.21680 DB - PRIME DP - Unbound Medicine ER -