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MicroRNAs in common diseases and potential therapeutic applications.
Clin Exp Pharmacol Physiol. 2010 Jan; 37(1):102-7.CE

Abstract

1. Evidence gathered in recent years has revealed microRNAs (miRNAs) fine-tune gene expression and play an important role in various cellular processes, including cell growth, differentiation, proliferation and apoptosis. 2. The present review summarizes current knowledge of miRNA pathways in the pathogenesis of cancer, cardiac diseases, neurodegenerative diseases, diabetes, autoimmune/inflammatory diseases and infection. 3. There is considerable potential to target miRNAs as a novel approach in the treatment of human diseases. Currently, miRNA-based therapies are being examined in both animal models and human clinical trials.

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Authors+Show Affiliations

Tsai LM
Immunology and Inflammation Research Program, Garvan Institute of Medical Research, Sydney, New South Wales, Australia.
Yu D
No affiliation info available

MeSH

AnimalsAutoimmune DiseasesDiabetes MellitusGene Expression RegulationGene Expression Regulation, NeoplasticGenetic TherapyHeart DiseasesHumansMicroRNAsModels, GeneticNeoplasmsNeurodegenerative DiseasesRNA InterferenceVirus Diseases

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

19671070

Citation

Tsai, Louis M., and Di Yu. "MicroRNAs in Common Diseases and Potential Therapeutic Applications." Clinical and Experimental Pharmacology & Physiology, vol. 37, no. 1, 2010, pp. 102-7.
Tsai LM, Yu D. MicroRNAs in common diseases and potential therapeutic applications. Clin Exp Pharmacol Physiol. 2010;37(1):102-7.
Tsai, L. M., & Yu, D. (2010). MicroRNAs in common diseases and potential therapeutic applications. Clinical and Experimental Pharmacology & Physiology, 37(1), 102-7. https://doi.org/10.1111/j.1440-1681.2009.05269.x
Tsai LM, Yu D. MicroRNAs in Common Diseases and Potential Therapeutic Applications. Clin Exp Pharmacol Physiol. 2010;37(1):102-7. PubMed PMID: 19671070.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - MicroRNAs in common diseases and potential therapeutic applications. AU - Tsai,Louis M, AU - Yu,Di, Y1 - 2009/08/04/ PY - 2009/8/13/entrez PY - 2009/8/13/pubmed PY - 2010/6/11/medline SP - 102 EP - 7 JF - Clinical and experimental pharmacology & physiology JO - Clin Exp Pharmacol Physiol VL - 37 IS - 1 N2 - 1. Evidence gathered in recent years has revealed microRNAs (miRNAs) fine-tune gene expression and play an important role in various cellular processes, including cell growth, differentiation, proliferation and apoptosis. 2. The present review summarizes current knowledge of miRNA pathways in the pathogenesis of cancer, cardiac diseases, neurodegenerative diseases, diabetes, autoimmune/inflammatory diseases and infection. 3. There is considerable potential to target miRNAs as a novel approach in the treatment of human diseases. Currently, miRNA-based therapies are being examined in both animal models and human clinical trials. SN - 1440-1681 UR - https://www.unboundmedicine.com/medline/citation/19671070/MicroRNAs_in_common_diseases_and_potential_therapeutic_applications_ L2 - https://doi.org/10.1111/j.1440-1681.2009.05269.x DB - PRIME DP - Unbound Medicine ER -