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Differences of proteolytic enzymes and pathological changes in permissive and nonpermissive animal hosts for Angiostrongylus cantonensis infection.
Vet Parasitol. 2009 Nov 12; 165(3-4):265-72.VP

Abstract

In this study, mice (nonpermissive hosts) infected with Angiostrongylus cantonensis showed significant worm degeneration and eosinophil degranulation, whereas infected rats (permissive hosts) showed lower worm degeneration and eosinophil degranulation. Pathophysiological changes developed to a lesser extent in rat than in the mouse strains. Neurological evaluation of A. cantonensis-infected mice showed mechanical damage caused by worms migrating to the brain. A significant correlation between the proteolytic enzymes, plasminogen activator (PA) and matrix metalloproteinase-9 (MMP-9), and pathological changes was found in hosts with eosinophilic meningitis or meningoencephalitis. Also, the ratio of cerebrospinal fluid (CSF) to serum albumin was consistently increased in hosts with angiostrongyliasis as compared with control. These data clearly indicate that PA and MMP-9 proteolytic enzymes as well as pathological changes are different in permissive and nonpermissive hosts.

Authors+Show Affiliations

Department of Laboratory, CiShan Hospital, 60 Chung-Hsueh Road, CiShan Chen, Kaohsiung County 842, Taiwan.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19671486

Citation

Lan, K P., and S C. Lai. "Differences of Proteolytic Enzymes and Pathological Changes in Permissive and Nonpermissive Animal Hosts for Angiostrongylus Cantonensis Infection." Veterinary Parasitology, vol. 165, no. 3-4, 2009, pp. 265-72.
Lan KP, Lai SC. Differences of proteolytic enzymes and pathological changes in permissive and nonpermissive animal hosts for Angiostrongylus cantonensis infection. Vet Parasitol. 2009;165(3-4):265-72.
Lan, K. P., & Lai, S. C. (2009). Differences of proteolytic enzymes and pathological changes in permissive and nonpermissive animal hosts for Angiostrongylus cantonensis infection. Veterinary Parasitology, 165(3-4), 265-72. https://doi.org/10.1016/j.vetpar.2009.07.029
Lan KP, Lai SC. Differences of Proteolytic Enzymes and Pathological Changes in Permissive and Nonpermissive Animal Hosts for Angiostrongylus Cantonensis Infection. Vet Parasitol. 2009 Nov 12;165(3-4):265-72. PubMed PMID: 19671486.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differences of proteolytic enzymes and pathological changes in permissive and nonpermissive animal hosts for Angiostrongylus cantonensis infection. AU - Lan,K P, AU - Lai,S C, Y1 - 2009/07/23/ PY - 2009/02/06/received PY - 2009/07/03/revised PY - 2009/07/15/accepted PY - 2009/8/13/entrez PY - 2009/8/13/pubmed PY - 2009/12/30/medline SP - 265 EP - 72 JF - Veterinary parasitology JO - Vet Parasitol VL - 165 IS - 3-4 N2 - In this study, mice (nonpermissive hosts) infected with Angiostrongylus cantonensis showed significant worm degeneration and eosinophil degranulation, whereas infected rats (permissive hosts) showed lower worm degeneration and eosinophil degranulation. Pathophysiological changes developed to a lesser extent in rat than in the mouse strains. Neurological evaluation of A. cantonensis-infected mice showed mechanical damage caused by worms migrating to the brain. A significant correlation between the proteolytic enzymes, plasminogen activator (PA) and matrix metalloproteinase-9 (MMP-9), and pathological changes was found in hosts with eosinophilic meningitis or meningoencephalitis. Also, the ratio of cerebrospinal fluid (CSF) to serum albumin was consistently increased in hosts with angiostrongyliasis as compared with control. These data clearly indicate that PA and MMP-9 proteolytic enzymes as well as pathological changes are different in permissive and nonpermissive hosts. SN - 1873-2550 UR - https://www.unboundmedicine.com/medline/citation/19671486/Differences_of_proteolytic_enzymes_and_pathological_changes_in_permissive_and_nonpermissive_animal_hosts_for_Angiostrongylus_cantonensis_infection_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-4017(09)00427-0 DB - PRIME DP - Unbound Medicine ER -