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Interactive effect of cigarette smoking with human 8-oxoguanine DNA N-glycosylase 1 (hOGG1) polymorphisms on the risk of lung cancer: a case-control study in Taiwan.
Am J Epidemiol 2009; 170(6):695-702AJ

Abstract

Human 8-oxoguanine DNA N-glycosylase 1 (hOGG1) plays an important role in repairing oxidative DNA damage induced by tobacco carcinogens. In this case-control study, the authors examined the interactive effect of hOGG1 gene polymorphisms and cigarette smoking on the risk of lung cancer in Taiwan. A total of 1,096 cases and 1,007 controls were enrolled from 6 medical centers in Taiwan during 2002-2004. hOGG1 Ser326Cys genetic polymorphisms were determined using the MassARRAY system (SEQUENOM, Inc., San Diego, California). Tobacco smoking history was obtained through personal interview according to a structured questionnaire. Logistic regression analysis was used to estimate multivariate-adjusted odds ratios and 95% confidence intervals. The odds of developing lung cancer for persons with the Cys/Cys genotype versus the Ser/Ser genotype were 1.11 (95% confidence interval (CI): 0.74, 1.65) for never smokers, 1.45 (95% CI: 0.74, 2.83) for moderate smokers, and 3.52 (95% CI: 1.54, 8.06) for heavy smokers. The P value for interaction in the logistic model was 0.01. The increased risk associated with the Cys/Cys genotype among heavy smokers remained statistically significant for various histologic types of lung cancer, including adenocarcinoma, squamous cell carcinoma, and small cell carcinoma. The authors conclude that there was a noticeable modifying effect on the association between hOGG1 genotype and lung cancer risk by cigarette smoking status.

Authors+Show Affiliations

Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan, Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comment
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19671832

Citation

Chang, Chin-Hao, et al. "Interactive Effect of Cigarette Smoking With Human 8-oxoguanine DNA N-glycosylase 1 (hOGG1) Polymorphisms On the Risk of Lung Cancer: a Case-control Study in Taiwan." American Journal of Epidemiology, vol. 170, no. 6, 2009, pp. 695-702.
Chang CH, Hsiao CF, Chang GC, et al. Interactive effect of cigarette smoking with human 8-oxoguanine DNA N-glycosylase 1 (hOGG1) polymorphisms on the risk of lung cancer: a case-control study in Taiwan. Am J Epidemiol. 2009;170(6):695-702.
Chang, C. H., Hsiao, C. F., Chang, G. C., Tsai, Y. H., Chen, Y. M., Huang, M. S., ... Hsiung, C. A. (2009). Interactive effect of cigarette smoking with human 8-oxoguanine DNA N-glycosylase 1 (hOGG1) polymorphisms on the risk of lung cancer: a case-control study in Taiwan. American Journal of Epidemiology, 170(6), pp. 695-702. doi:10.1093/aje/kwp019.
Chang CH, et al. Interactive Effect of Cigarette Smoking With Human 8-oxoguanine DNA N-glycosylase 1 (hOGG1) Polymorphisms On the Risk of Lung Cancer: a Case-control Study in Taiwan. Am J Epidemiol. 2009 Sep 15;170(6):695-702. PubMed PMID: 19671832.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interactive effect of cigarette smoking with human 8-oxoguanine DNA N-glycosylase 1 (hOGG1) polymorphisms on the risk of lung cancer: a case-control study in Taiwan. AU - Chang,Chin-Hao, AU - Hsiao,Chin-Fu, AU - Chang,Gee-Chen, AU - Tsai,Ying-Huang, AU - Chen,Yuh-Min, AU - Huang,Ming-Shyan, AU - Su,Wu-Chou, AU - Hsieh,Wan-Shan, AU - Yang,Pan-Chyr, AU - Chen,Chien-Jen, AU - Hsiung,Chao A, Y1 - 2009/08/11/ PY - 2009/8/13/entrez PY - 2009/8/13/pubmed PY - 2009/9/24/medline SP - 695 EP - 702 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 170 IS - 6 N2 - Human 8-oxoguanine DNA N-glycosylase 1 (hOGG1) plays an important role in repairing oxidative DNA damage induced by tobacco carcinogens. In this case-control study, the authors examined the interactive effect of hOGG1 gene polymorphisms and cigarette smoking on the risk of lung cancer in Taiwan. A total of 1,096 cases and 1,007 controls were enrolled from 6 medical centers in Taiwan during 2002-2004. hOGG1 Ser326Cys genetic polymorphisms were determined using the MassARRAY system (SEQUENOM, Inc., San Diego, California). Tobacco smoking history was obtained through personal interview according to a structured questionnaire. Logistic regression analysis was used to estimate multivariate-adjusted odds ratios and 95% confidence intervals. The odds of developing lung cancer for persons with the Cys/Cys genotype versus the Ser/Ser genotype were 1.11 (95% confidence interval (CI): 0.74, 1.65) for never smokers, 1.45 (95% CI: 0.74, 2.83) for moderate smokers, and 3.52 (95% CI: 1.54, 8.06) for heavy smokers. The P value for interaction in the logistic model was 0.01. The increased risk associated with the Cys/Cys genotype among heavy smokers remained statistically significant for various histologic types of lung cancer, including adenocarcinoma, squamous cell carcinoma, and small cell carcinoma. The authors conclude that there was a noticeable modifying effect on the association between hOGG1 genotype and lung cancer risk by cigarette smoking status. SN - 1476-6256 UR - https://www.unboundmedicine.com/medline/citation/19671832/Interactive_effect_of_cigarette_smoking_with_human_8_oxoguanine_DNA_N_glycosylase_1__hOGG1__polymorphisms_on_the_risk_of_lung_cancer:_a_case_control_study_in_Taiwan_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwp019 DB - PRIME DP - Unbound Medicine ER -