Tags

Type your tag names separated by a space and hit enter

Human parvovirus B19 (B19V) infection in systemic sclerosis patients.
Intervirology. 2009; 52(5):279-82.I

Abstract

BACKGROUND

Our previous reports suggested a possible association between parvovirus B19 (B19V) infection and systemic sclerosis (SSc), based on higher prevalence of B19V DNA in SSc patients in respect to controls.

METHODS

In the present study, to further evaluate the differences in the pattern of B19 infection in SSc, skin biopsies and bone marrow samples from patients and controls were analysed for B19V DNA detection, genotyping and viral expression.

RESULTS

B19V DNA was detected in skin biopsies from 39/49 SSc patients and from 20/28 controls. Bone marrow showed positive in 17/29 SSc patients, 5/21 haematological patients and 0/10 healthy controls. Genotype 1 was more frequent in skin and bone marrow from patients than from controls. Simultaneous persistence of 2 genotypes was detected in SSc skin and bone marrow samples, never in controls. Viral mRNA for capsid protein was detected in the skin of genotype 1-positive patients and not in control skins.

CONCLUSION

The results outline some differences in the rate of persistence of B19V DNA, in the simultaneous persistence of 2 genotypes and in the pattern of viral expression among SSc patients and controls.

Authors+Show Affiliations

Department of Public Health, Microbiology and Virology Unit, University of Florence Florence, Italy. krystyna.zakrzewska@unifi.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19672101

Citation

Zakrzewska, Krystyna, et al. "Human Parvovirus B19 (B19V) Infection in Systemic Sclerosis Patients." Intervirology, vol. 52, no. 5, 2009, pp. 279-82.
Zakrzewska K, Corcioli F, Carlsen KM, et al. Human parvovirus B19 (B19V) infection in systemic sclerosis patients. Intervirology. 2009;52(5):279-82.
Zakrzewska, K., Corcioli, F., Carlsen, K. M., Giuggioli, D., Fanci, R., Rinieri, A., Ferri, C., & Azzi, A. (2009). Human parvovirus B19 (B19V) infection in systemic sclerosis patients. Intervirology, 52(5), 279-82. https://doi.org/10.1159/000232945
Zakrzewska K, et al. Human Parvovirus B19 (B19V) Infection in Systemic Sclerosis Patients. Intervirology. 2009;52(5):279-82. PubMed PMID: 19672101.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Human parvovirus B19 (B19V) infection in systemic sclerosis patients. AU - Zakrzewska,Krystyna, AU - Corcioli,Fabiana, AU - Carlsen,Karen M, AU - Giuggioli,Dilia, AU - Fanci,Rosa, AU - Rinieri,Alessio, AU - Ferri,Clodoveo, AU - Azzi,Alberta, Y1 - 2009/08/07/ PY - 2009/03/09/received PY - 2009/06/24/accepted PY - 2009/8/13/entrez PY - 2009/8/13/pubmed PY - 2009/11/7/medline SP - 279 EP - 82 JF - Intervirology JO - Intervirology VL - 52 IS - 5 N2 - BACKGROUND: Our previous reports suggested a possible association between parvovirus B19 (B19V) infection and systemic sclerosis (SSc), based on higher prevalence of B19V DNA in SSc patients in respect to controls. METHODS: In the present study, to further evaluate the differences in the pattern of B19 infection in SSc, skin biopsies and bone marrow samples from patients and controls were analysed for B19V DNA detection, genotyping and viral expression. RESULTS: B19V DNA was detected in skin biopsies from 39/49 SSc patients and from 20/28 controls. Bone marrow showed positive in 17/29 SSc patients, 5/21 haematological patients and 0/10 healthy controls. Genotype 1 was more frequent in skin and bone marrow from patients than from controls. Simultaneous persistence of 2 genotypes was detected in SSc skin and bone marrow samples, never in controls. Viral mRNA for capsid protein was detected in the skin of genotype 1-positive patients and not in control skins. CONCLUSION: The results outline some differences in the rate of persistence of B19V DNA, in the simultaneous persistence of 2 genotypes and in the pattern of viral expression among SSc patients and controls. SN - 1423-0100 UR - https://www.unboundmedicine.com/medline/citation/19672101/Human_parvovirus_B19__B19V__infection_in_systemic_sclerosis_patients_ L2 - https://www.karger.com?DOI=10.1159/000232945 DB - PRIME DP - Unbound Medicine ER -