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Use of bacterial lipopolysaccharide (LPS) as an immunostimulant for the control of Aeromonas hydrophila infections in rainbow trout Oncorhynchus mykiss (Walbaum).
J Appl Microbiol. 2010 Feb; 108(2):686-94.JA

Abstract

AIMS

To determine the effect of lipopolysaccharide (LPS) for the prevention of infection by Aeromonas hydrophila in rainbow trout (Oncorhynchus mykiss Walbaum) fingerlings.

METHODS AND RESULTS

Rainbow trout fingerlings were fed with 0 mg (= controls), 1.875 mg, 3.75 mg, 7.5 mg and 15 mg of LPS per 100 g of commercial feed for 14 days before experimental challenge with A. hydrophila. The results revealed a reduction in mortalities to 5% in the two lowest doses and 15% in the group, which received 15 mg LPS per 100 g of feed, compared with 45% mortalities in the control. LPS exerted a powerful oxidative burst effect and was a potent mediator of phagocytic, lysozyme, bactericidal and antiprotease activities and total protein. However, whereas there were increases in specific growth rate (SGR), feed conversion ratio (FCR) and protein efficiency ratio (PER) in LPS-treated fish, the data were not significantly (P > 0.05) different.

CONCLUSIONS

LPS was effective at preventing disease caused by A. hydrophila and in stimulating the innate immune response of rainbow trout.

SIGNIFICANCE AND IMPACT OF THE STUDY

The results of this study highlight the role of LPS in fish disease control.

Authors+Show Affiliations

School of Life Sciences, Heriot-Watt University, Edinburgh, Scotland, UK.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19674184

Citation

Nya, E J., and B Austin. "Use of Bacterial Lipopolysaccharide (LPS) as an Immunostimulant for the Control of Aeromonas Hydrophila Infections in Rainbow Trout Oncorhynchus Mykiss (Walbaum)." Journal of Applied Microbiology, vol. 108, no. 2, 2010, pp. 686-94.
Nya EJ, Austin B. Use of bacterial lipopolysaccharide (LPS) as an immunostimulant for the control of Aeromonas hydrophila infections in rainbow trout Oncorhynchus mykiss (Walbaum). J Appl Microbiol. 2010;108(2):686-94.
Nya, E. J., & Austin, B. (2010). Use of bacterial lipopolysaccharide (LPS) as an immunostimulant for the control of Aeromonas hydrophila infections in rainbow trout Oncorhynchus mykiss (Walbaum). Journal of Applied Microbiology, 108(2), 686-94. https://doi.org/10.1111/j.1365-2672.2009.04464.x
Nya EJ, Austin B. Use of Bacterial Lipopolysaccharide (LPS) as an Immunostimulant for the Control of Aeromonas Hydrophila Infections in Rainbow Trout Oncorhynchus Mykiss (Walbaum). J Appl Microbiol. 2010;108(2):686-94. PubMed PMID: 19674184.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Use of bacterial lipopolysaccharide (LPS) as an immunostimulant for the control of Aeromonas hydrophila infections in rainbow trout Oncorhynchus mykiss (Walbaum). AU - Nya,E J, AU - Austin,B, Y1 - 2009/07/07/ PY - 2009/8/14/entrez PY - 2009/8/14/pubmed PY - 2010/7/14/medline SP - 686 EP - 94 JF - Journal of applied microbiology JO - J Appl Microbiol VL - 108 IS - 2 N2 - AIMS: To determine the effect of lipopolysaccharide (LPS) for the prevention of infection by Aeromonas hydrophila in rainbow trout (Oncorhynchus mykiss Walbaum) fingerlings. METHODS AND RESULTS: Rainbow trout fingerlings were fed with 0 mg (= controls), 1.875 mg, 3.75 mg, 7.5 mg and 15 mg of LPS per 100 g of commercial feed for 14 days before experimental challenge with A. hydrophila. The results revealed a reduction in mortalities to 5% in the two lowest doses and 15% in the group, which received 15 mg LPS per 100 g of feed, compared with 45% mortalities in the control. LPS exerted a powerful oxidative burst effect and was a potent mediator of phagocytic, lysozyme, bactericidal and antiprotease activities and total protein. However, whereas there were increases in specific growth rate (SGR), feed conversion ratio (FCR) and protein efficiency ratio (PER) in LPS-treated fish, the data were not significantly (P > 0.05) different. CONCLUSIONS: LPS was effective at preventing disease caused by A. hydrophila and in stimulating the innate immune response of rainbow trout. SIGNIFICANCE AND IMPACT OF THE STUDY: The results of this study highlight the role of LPS in fish disease control. SN - 1365-2672 UR - https://www.unboundmedicine.com/medline/citation/19674184/Use_of_bacterial_lipopolysaccharide__LPS__as_an_immunostimulant_for_the_control_of_Aeromonas_hydrophila_infections_in_rainbow_trout_Oncorhynchus_mykiss__Walbaum__ L2 - https://doi.org/10.1111/j.1365-2672.2009.04464.x DB - PRIME DP - Unbound Medicine ER -