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Electrophysiological indices of abnormal error-processing in adolescents with attention deficit hyperactivity disorder (ADHD).
J Child Psychol Psychiatry 2010; 51(1):66-76JC

Abstract

BACKGROUND

Impaired cognitive control has been frequently observed in children and young people with attention deficit hyperactivity disorder (ADHD) and might underlie the excessive hyperactivity and impulsivity in this population. We investigated behavioural and electrophysiological indices relevant to one domain of cognitive control; namely error processing.

METHODS

Adolescents aged 14 to 17 with ADHD (n = 23) and a typically developing control group (HC; n = 19) performed a visual go/no-go task. Electro-encephalography (EEG) data were collected simultaneously and response-locked error trials were averaged to derive two event-related potentials, the error-related negativity (ERN) and error positivity (Pe). Evoked theta power and inter-trial phase coherence (ITC) were measured in two time windows ('early' and 'late') equivalent to those used for detection of the ERN and Pe.

RESULTS

Analysis revealed normal ERN amplitude and a statistical trend for smaller Pe amplitude at a fronto-central electrode site in the ADHD group. The group also showed significant reductions in late evoked theta power and early and late theta ITC. Relationships between behavioural measures and ITC were different between groups, particularly for post-error slowing, a measure of strategic response adjustment on trials immediately following an error.

CONCLUSIONS

The results reveal abnormalities in behavioural and electrophysiological indices of error processing in adolescents with ADHD and suggest that ITC is more sensitive than traditional ERP measures to error-processing abnormalities.

Authors+Show Affiliations

Developmental Psychiatry, University of Nottingham, UK. maddie.groom@nottingham.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19674196

Citation

Groom, Madeleine J., et al. "Electrophysiological Indices of Abnormal Error-processing in Adolescents With Attention Deficit Hyperactivity Disorder (ADHD)." Journal of Child Psychology and Psychiatry, and Allied Disciplines, vol. 51, no. 1, 2010, pp. 66-76.
Groom MJ, Cahill JD, Bates AT, et al. Electrophysiological indices of abnormal error-processing in adolescents with attention deficit hyperactivity disorder (ADHD). J Child Psychol Psychiatry. 2010;51(1):66-76.
Groom, M. J., Cahill, J. D., Bates, A. T., Jackson, G. M., Calton, T. G., Liddle, P. F., & Hollis, C. (2010). Electrophysiological indices of abnormal error-processing in adolescents with attention deficit hyperactivity disorder (ADHD). Journal of Child Psychology and Psychiatry, and Allied Disciplines, 51(1), pp. 66-76. doi:10.1111/j.1469-7610.2009.02128.x.
Groom MJ, et al. Electrophysiological Indices of Abnormal Error-processing in Adolescents With Attention Deficit Hyperactivity Disorder (ADHD). J Child Psychol Psychiatry. 2010;51(1):66-76. PubMed PMID: 19674196.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Electrophysiological indices of abnormal error-processing in adolescents with attention deficit hyperactivity disorder (ADHD). AU - Groom,Madeleine J, AU - Cahill,John D, AU - Bates,Alan T, AU - Jackson,Georgina M, AU - Calton,Timothy G, AU - Liddle,Peter F, AU - Hollis,Chris, Y1 - 2009/08/06/ PY - 2009/8/14/entrez PY - 2009/8/14/pubmed PY - 2010/4/16/medline SP - 66 EP - 76 JF - Journal of child psychology and psychiatry, and allied disciplines JO - J Child Psychol Psychiatry VL - 51 IS - 1 N2 - BACKGROUND: Impaired cognitive control has been frequently observed in children and young people with attention deficit hyperactivity disorder (ADHD) and might underlie the excessive hyperactivity and impulsivity in this population. We investigated behavioural and electrophysiological indices relevant to one domain of cognitive control; namely error processing. METHODS: Adolescents aged 14 to 17 with ADHD (n = 23) and a typically developing control group (HC; n = 19) performed a visual go/no-go task. Electro-encephalography (EEG) data were collected simultaneously and response-locked error trials were averaged to derive two event-related potentials, the error-related negativity (ERN) and error positivity (Pe). Evoked theta power and inter-trial phase coherence (ITC) were measured in two time windows ('early' and 'late') equivalent to those used for detection of the ERN and Pe. RESULTS: Analysis revealed normal ERN amplitude and a statistical trend for smaller Pe amplitude at a fronto-central electrode site in the ADHD group. The group also showed significant reductions in late evoked theta power and early and late theta ITC. Relationships between behavioural measures and ITC were different between groups, particularly for post-error slowing, a measure of strategic response adjustment on trials immediately following an error. CONCLUSIONS: The results reveal abnormalities in behavioural and electrophysiological indices of error processing in adolescents with ADHD and suggest that ITC is more sensitive than traditional ERP measures to error-processing abnormalities. SN - 1469-7610 UR - https://www.unboundmedicine.com/medline/citation/19674196/Electrophysiological_indices_of_abnormal_error_processing_in_adolescents_with_attention_deficit_hyperactivity_disorder__ADHD__ L2 - https://doi.org/10.1111/j.1469-7610.2009.02128.x DB - PRIME DP - Unbound Medicine ER -