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The transient and cumulative effect of sodium lauryl sulphate on the epidermal barrier assessed by transepidermal water loss: inter-individual variation.
Acta Derm Venereol. 1990; 70(1):1-5.AD

Abstract

The aims of the investigation were: 1) to study the inter-individual variation in time course of TransEpidermal Water Loss and of clinical manifestations after a 24-h single exposure to Sodium Lauryl Sulphate. This TEWL time course (expressed as the difference in TEWL between the day of patch removal and a subsequent day) reflected the epidermal barrier response to the damage caused by SLS; 2) to investigate the association between the TEWL time course after the single SLS exposure and the TEWL value after 4-day repeated SLS exposure (as a model for cumulative irritation). The 35 healthy subjects tested could be divided into four sub-groups according to the day of their maximum TEWL value after the single SLS exposure (days 2 to 5). For the whole group, inter-individual variation in TEWL course was most pronounced in the first days following the single SLS application. Moreover, there was an inverse relationship (R = -0.61) between TEWL course during the first days after the single exposure and the TEWL value after 4-day repeated exposures. It is concluded that this association illustrates the importance of an adequately responding barrier function against the continuous exposure to irritants in daily life.

Authors+Show Affiliations

Tupker RA
Occupational Dermatology Unit, State University Hospital, Groningen, The Netherlands.
Pinnagoda J
No affiliation info available
Nater JP
No affiliation info available

MeSH

AdultFemaleHumansIrritantsMaleMiddle AgedSkin Physiological PhenomenaSodium Dodecyl SulfateTime FactorsWater Loss, Insensible

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1967864

Citation

Tupker, R A., et al. "The Transient and Cumulative Effect of Sodium Lauryl Sulphate On the Epidermal Barrier Assessed By Transepidermal Water Loss: Inter-individual Variation." Acta Dermato-venereologica, vol. 70, no. 1, 1990, pp. 1-5.
Tupker RA, Pinnagoda J, Nater JP. The transient and cumulative effect of sodium lauryl sulphate on the epidermal barrier assessed by transepidermal water loss: inter-individual variation. Acta Derm Venereol. 1990;70(1):1-5.
Tupker, R. A., Pinnagoda, J., & Nater, J. P. (1990). The transient and cumulative effect of sodium lauryl sulphate on the epidermal barrier assessed by transepidermal water loss: inter-individual variation. Acta Dermato-venereologica, 70(1), 1-5.
Tupker RA, Pinnagoda J, Nater JP. The Transient and Cumulative Effect of Sodium Lauryl Sulphate On the Epidermal Barrier Assessed By Transepidermal Water Loss: Inter-individual Variation. Acta Derm Venereol. 1990;70(1):1-5. PubMed PMID: 1967864.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The transient and cumulative effect of sodium lauryl sulphate on the epidermal barrier assessed by transepidermal water loss: inter-individual variation. AU - Tupker,R A, AU - Pinnagoda,J, AU - Nater,J P, PY - 1990/1/1/pubmed PY - 1990/1/1/medline PY - 1990/1/1/entrez SP - 1 EP - 5 JF - Acta dermato-venereologica JO - Acta Derm Venereol VL - 70 IS - 1 N2 - The aims of the investigation were: 1) to study the inter-individual variation in time course of TransEpidermal Water Loss and of clinical manifestations after a 24-h single exposure to Sodium Lauryl Sulphate. This TEWL time course (expressed as the difference in TEWL between the day of patch removal and a subsequent day) reflected the epidermal barrier response to the damage caused by SLS; 2) to investigate the association between the TEWL time course after the single SLS exposure and the TEWL value after 4-day repeated SLS exposure (as a model for cumulative irritation). The 35 healthy subjects tested could be divided into four sub-groups according to the day of their maximum TEWL value after the single SLS exposure (days 2 to 5). For the whole group, inter-individual variation in TEWL course was most pronounced in the first days following the single SLS application. Moreover, there was an inverse relationship (R = -0.61) between TEWL course during the first days after the single exposure and the TEWL value after 4-day repeated exposures. It is concluded that this association illustrates the importance of an adequately responding barrier function against the continuous exposure to irritants in daily life. SN - 0001-5555 UR - https://www.unboundmedicine.com/medline/citation/1967864/The_transient_and_cumulative_effect_of_sodium_lauryl_sulphate_on_the_epidermal_barrier_assessed_by_transepidermal_water_loss:_inter_individual_variation_ DB - PRIME DP - Unbound Medicine ER -