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Molecular and serologic markers of acute dengue infection in naive and flavivirus-vaccinated travelers.
Diagn Microbiol Infect Dis. 2009 Sep; 65(1):42-8.DM

Abstract

A total of 520 European travelers with suspected dengue fever were examined, and acute dengue virus infection was confirmed in 127 of them. Molecular and serological tests for dengue diagnosis, according to their usefulness in the different stages of the disease, were performed. The accuracy of the IgM/IgG ratio and the IgG avidity index was confirmed during the early phase of the illness to discriminate the serologic status (primary versus secondary immune response) of patients who were either naive or previously vaccinated against other flaviviruses. Virologic markers of secondary infection were detected in 11.8% of nonvaccinated infected patients and in 92.6% of yellow fever vaccinated patients. The proper use of these simple methodologies could help in the identification of patients affected with secondary infection, who may be at a higher risk of developing a hemorrhagic disorder.

Authors+Show Affiliations

Diagnostic Microbiology Service, National Center for Microbiology, Instituto de Salud Carlos III, 28220 Madrid, Spain. domingo-carrascoc@rki.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19679234

Citation

Domingo, Cristina, et al. "Molecular and Serologic Markers of Acute Dengue Infection in Naive and Flavivirus-vaccinated Travelers." Diagnostic Microbiology and Infectious Disease, vol. 65, no. 1, 2009, pp. 42-8.
Domingo C, de Ory F, Sanz JC, et al. Molecular and serologic markers of acute dengue infection in naive and flavivirus-vaccinated travelers. Diagn Microbiol Infect Dis. 2009;65(1):42-8.
Domingo, C., de Ory, F., Sanz, J. C., Reyes, N., Gascón, J., Wichmann, O., Puente, S., Schunk, M., López-Vélez, R., Ruiz, J., & Tenorio, A. (2009). Molecular and serologic markers of acute dengue infection in naive and flavivirus-vaccinated travelers. Diagnostic Microbiology and Infectious Disease, 65(1), 42-8. https://doi.org/10.1016/j.diagmicrobio.2009.05.004
Domingo C, et al. Molecular and Serologic Markers of Acute Dengue Infection in Naive and Flavivirus-vaccinated Travelers. Diagn Microbiol Infect Dis. 2009;65(1):42-8. PubMed PMID: 19679234.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Molecular and serologic markers of acute dengue infection in naive and flavivirus-vaccinated travelers. AU - Domingo,Cristina, AU - de Ory,Fernando, AU - Sanz,Juan Carlos, AU - Reyes,Noelia, AU - Gascón,Joaquim, AU - Wichmann,Ole, AU - Puente,Sabino, AU - Schunk,Mirjam, AU - López-Vélez,Rogelio, AU - Ruiz,Joaquim, AU - Tenorio,Antonio, PY - 2009/01/23/received PY - 2009/04/14/revised PY - 2009/05/05/accepted PY - 2009/8/15/entrez PY - 2009/8/15/pubmed PY - 2009/10/10/medline SP - 42 EP - 8 JF - Diagnostic microbiology and infectious disease JO - Diagn Microbiol Infect Dis VL - 65 IS - 1 N2 - A total of 520 European travelers with suspected dengue fever were examined, and acute dengue virus infection was confirmed in 127 of them. Molecular and serological tests for dengue diagnosis, according to their usefulness in the different stages of the disease, were performed. The accuracy of the IgM/IgG ratio and the IgG avidity index was confirmed during the early phase of the illness to discriminate the serologic status (primary versus secondary immune response) of patients who were either naive or previously vaccinated against other flaviviruses. Virologic markers of secondary infection were detected in 11.8% of nonvaccinated infected patients and in 92.6% of yellow fever vaccinated patients. The proper use of these simple methodologies could help in the identification of patients affected with secondary infection, who may be at a higher risk of developing a hemorrhagic disorder. SN - 1879-0070 UR - https://www.unboundmedicine.com/medline/citation/19679234/Molecular_and_serologic_markers_of_acute_dengue_infection_in_naive_and_flavivirus_vaccinated_travelers_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0732-8893(09)00196-5 DB - PRIME DP - Unbound Medicine ER -