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Meningovascular syphilis with fatal vertebrobasilar occlusion.
Am J Med Sci 2009; 338(2):169-71AJ

Abstract

We report the case of a young patient with meningovascular syphilis who suffered fatal vertebrobasilar occlusion despite thrombolytic treatment and endovascular interventions. A 35-year-old man without any known medical history presented with an acute ischemic stroke and was initially treated with intravenous tissue plasminogen activator. He was then transferred to the stroke center, where he underwent endovascular recanalization of his occluded vertebrobasilar system. Despite initial successful recanalization, he suffered recurrent vertebrobasilar occlusion, and a second endovascular treatment attempt was unsuccessful. He subsequently developed a pontine hemorrhage and acute hydrocephalus and died secondary to transtentorial herniation. Laboratory findings were suggestive of prior spirochetal infection, and autopsy revealed necrotizing vasculitis and extensive adventitial inflammation involving the basilar and vertebral arteries, supporting the diagnosis of meningovascular syphilis.

Authors+Show Affiliations

Department of Neurosciences, 96 Jonathan Lucas Street, Medical University of South Carolina, Charleston, South Carolina 29425, USA. feng@musc.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

19680027

Citation

Feng, Wuwei, et al. "Meningovascular Syphilis With Fatal Vertebrobasilar Occlusion." The American Journal of the Medical Sciences, vol. 338, no. 2, 2009, pp. 169-71.
Feng W, Caplan M, Matheus MG, et al. Meningovascular syphilis with fatal vertebrobasilar occlusion. Am J Med Sci. 2009;338(2):169-71.
Feng, W., Caplan, M., Matheus, M. G., & Papamitsakis, N. I. (2009). Meningovascular syphilis with fatal vertebrobasilar occlusion. The American Journal of the Medical Sciences, 338(2), pp. 169-71. doi:10.1097/MAJ.0b013e3181a40b81.
Feng W, et al. Meningovascular Syphilis With Fatal Vertebrobasilar Occlusion. Am J Med Sci. 2009;338(2):169-71. PubMed PMID: 19680027.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Meningovascular syphilis with fatal vertebrobasilar occlusion. AU - Feng,Wuwei, AU - Caplan,Michael, AU - Matheus,Maria G, AU - Papamitsakis,Nikolaos I H, PY - 2009/8/15/entrez PY - 2009/8/15/pubmed PY - 2009/9/9/medline SP - 169 EP - 71 JF - The American journal of the medical sciences JO - Am. J. Med. Sci. VL - 338 IS - 2 N2 - We report the case of a young patient with meningovascular syphilis who suffered fatal vertebrobasilar occlusion despite thrombolytic treatment and endovascular interventions. A 35-year-old man without any known medical history presented with an acute ischemic stroke and was initially treated with intravenous tissue plasminogen activator. He was then transferred to the stroke center, where he underwent endovascular recanalization of his occluded vertebrobasilar system. Despite initial successful recanalization, he suffered recurrent vertebrobasilar occlusion, and a second endovascular treatment attempt was unsuccessful. He subsequently developed a pontine hemorrhage and acute hydrocephalus and died secondary to transtentorial herniation. Laboratory findings were suggestive of prior spirochetal infection, and autopsy revealed necrotizing vasculitis and extensive adventitial inflammation involving the basilar and vertebral arteries, supporting the diagnosis of meningovascular syphilis. SN - 0002-9629 UR - https://www.unboundmedicine.com/medline/citation/19680027/Meningovascular_syphilis_with_fatal_vertebrobasilar_occlusion_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9629(15)31918-2 DB - PRIME DP - Unbound Medicine ER -