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Retinal nerve fiber layer thickness measurement by scanning laser polarimetry (GDxVCC) at conventional and modified diameter scans in normals, glaucoma suspects, and early glaucoma patients.
J Glaucoma. 2009 Aug; 18(6):448-52.JG

Abstract

PURPOSE

To study the retinal nerve fiber layer (RNFL) at 3 different scan diameters using GDxVCC in healthy, primary open-angle glaucoma (POAG) suspects, and early POAG.

METHOD

RNFL parameters were evaluated in 100 normal subjects, 50 POAG suspects, and 50 early POAG patients using GDxVCC at conventional small, medium, and large circle. TSNIT (temporal, superior, nasal, inferior, temporal) average, superior average, inferior average RNFL thickness, and nerve fiber indicator (NFI) were evaluated.

RESULTS

The TSNIT average (microm) in normal subjects, POAG suspects, and POAG at 3 different circles was 54.17+/-4.6, 49.96+/-6.5, 46.92+/-6.2 (small); 47.17+/-4.8, 43.79+/-5.7, 41.48+/-6.5 (medium); and 41.57+/-4.6, 39.77+/-5.9, 38.33+/-7.1 (large). All RNFL parameters at all circles showed significant difference between normal and early POAG eyes (P<0.001). Area under the curve was 0.911 for NFI at all circles. All parameters at small and medium circle, all except TSNIT average at large circle showed significant difference between normal and POAG suspects (P<0.001), area under curve being the highest (0.780 to 0.801 at 3 circles) for NFI. All parameters progressively decreased with increasing diameter with significant difference between small-medium (P<0.001), medium-large (P<0.001), and small-large circle results (P<0.001) in all the groups for all parameters except NFI.

CONCLUSIONS

Medium and large circles can also be used for RNFL evaluation in glaucoma. NFI is the best discriminating measure across all scan diameters.

Authors+Show Affiliations

Glaucoma Facility, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India. tanujdada@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19680052

Citation

Dada, Tanuj, et al. "Retinal Nerve Fiber Layer Thickness Measurement By Scanning Laser Polarimetry (GDxVCC) at Conventional and Modified Diameter Scans in Normals, Glaucoma Suspects, and Early Glaucoma Patients." Journal of Glaucoma, vol. 18, no. 6, 2009, pp. 448-52.
Dada T, Gadia R, Aggarwal A, et al. Retinal nerve fiber layer thickness measurement by scanning laser polarimetry (GDxVCC) at conventional and modified diameter scans in normals, glaucoma suspects, and early glaucoma patients. J Glaucoma. 2009;18(6):448-52.
Dada, T., Gadia, R., Aggarwal, A., Dave, V., Gupta, V., & Sihota, R. (2009). Retinal nerve fiber layer thickness measurement by scanning laser polarimetry (GDxVCC) at conventional and modified diameter scans in normals, glaucoma suspects, and early glaucoma patients. Journal of Glaucoma, 18(6), 448-52. https://doi.org/10.1097/IJG.0b013e3181895e2b
Dada T, et al. Retinal Nerve Fiber Layer Thickness Measurement By Scanning Laser Polarimetry (GDxVCC) at Conventional and Modified Diameter Scans in Normals, Glaucoma Suspects, and Early Glaucoma Patients. J Glaucoma. 2009;18(6):448-52. PubMed PMID: 19680052.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Retinal nerve fiber layer thickness measurement by scanning laser polarimetry (GDxVCC) at conventional and modified diameter scans in normals, glaucoma suspects, and early glaucoma patients. AU - Dada,Tanuj, AU - Gadia,Ritu, AU - Aggarwal,Anand, AU - Dave,Vivek, AU - Gupta,Viney, AU - Sihota,Ramanjit, PY - 2009/8/15/entrez PY - 2009/8/15/pubmed PY - 2009/10/8/medline SP - 448 EP - 52 JF - Journal of glaucoma JO - J Glaucoma VL - 18 IS - 6 N2 - PURPOSE: To study the retinal nerve fiber layer (RNFL) at 3 different scan diameters using GDxVCC in healthy, primary open-angle glaucoma (POAG) suspects, and early POAG. METHOD: RNFL parameters were evaluated in 100 normal subjects, 50 POAG suspects, and 50 early POAG patients using GDxVCC at conventional small, medium, and large circle. TSNIT (temporal, superior, nasal, inferior, temporal) average, superior average, inferior average RNFL thickness, and nerve fiber indicator (NFI) were evaluated. RESULTS: The TSNIT average (microm) in normal subjects, POAG suspects, and POAG at 3 different circles was 54.17+/-4.6, 49.96+/-6.5, 46.92+/-6.2 (small); 47.17+/-4.8, 43.79+/-5.7, 41.48+/-6.5 (medium); and 41.57+/-4.6, 39.77+/-5.9, 38.33+/-7.1 (large). All RNFL parameters at all circles showed significant difference between normal and early POAG eyes (P<0.001). Area under the curve was 0.911 for NFI at all circles. All parameters at small and medium circle, all except TSNIT average at large circle showed significant difference between normal and POAG suspects (P<0.001), area under curve being the highest (0.780 to 0.801 at 3 circles) for NFI. All parameters progressively decreased with increasing diameter with significant difference between small-medium (P<0.001), medium-large (P<0.001), and small-large circle results (P<0.001) in all the groups for all parameters except NFI. CONCLUSIONS: Medium and large circles can also be used for RNFL evaluation in glaucoma. NFI is the best discriminating measure across all scan diameters. SN - 1536-481X UR - https://www.unboundmedicine.com/medline/citation/19680052/Retinal_nerve_fiber_layer_thickness_measurement_by_scanning_laser_polarimetry__GDxVCC__at_conventional_and_modified_diameter_scans_in_normals_glaucoma_suspects_and_early_glaucoma_patients_ L2 - https://doi.org/10.1097/IJG.0b013e3181895e2b DB - PRIME DP - Unbound Medicine ER -