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Comparison of esophageal pH and multichannel intraluminal impedance testing in pediatric patients with suspected gastroesophageal reflux.
J Pediatr Gastroenterol Nutr 2010; 50(2):154-60JP

Abstract

BACKGROUND

Multichannel intraluminal impedance (MII) is a pH-independent method of assessing gastroesophageal reflux.

AIM

To evaluate the diagnostic accuracy of MII-pH as compared with conventional pH monitoring in detecting reflux events (REs) and symptom association in different age groups.

METHODS

: A prospective direct comparison of 2 diagnostic techniques on 291 consecutive patients referred for suspected gastroesophageal reflux disease. Sensitivity and diagnostic accuracy of MII-pH versus pH monitoring and symptom association were measured.

RESULTS

MII-pH detected 13631 REs, 6260 (46%) of which were nonacid. The prevalence of weakly acid refluxes in the 24 hours and postprandial period as well as the proximal extension of refluxate were significantly greater in infants as compared with children (P < 0.001, P < 0.001, and P < 0.01, respectively). The diagnostic accuracy of combined MII-pH in revealing all RE and acid RE were significantly higher in infants as compared with children (92% vs 82%, P < 0.01 and 83% vs 76%, P < 0.04, respectively). The addition of MII to conventional pH monitoring significantly increases the diagnostic yield of symptom association analysis in revealing an association between atypical symptoms and refluxes irrespective of age, whereas in studying typical symptoms it was true only for infants.

CONCLUSIONS

Addition of MII to conventional pH monitoring significantly increases the diagnostic yield in detecting REs, prevalently in infants, and in revealing an association between refluxes and symptoms, prevalently respiratory ones and in infants group.

Authors+Show Affiliations

Department of Biomedicina dell'Età Evolutiva, University of Bari, Italy. rfrancavilla@libero.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Evaluation Study
Journal Article

Language

eng

PubMed ID

19680154

Citation

Francavilla, Ruggiero, et al. "Comparison of Esophageal pH and Multichannel Intraluminal Impedance Testing in Pediatric Patients With Suspected Gastroesophageal Reflux." Journal of Pediatric Gastroenterology and Nutrition, vol. 50, no. 2, 2010, pp. 154-60.
Francavilla R, Magistà AM, Bucci N, et al. Comparison of esophageal pH and multichannel intraluminal impedance testing in pediatric patients with suspected gastroesophageal reflux. J Pediatr Gastroenterol Nutr. 2010;50(2):154-60.
Francavilla, R., Magistà, A. M., Bucci, N., Villirillo, A., Boscarelli, G., Mappa, L., ... Cavallo, L. (2010). Comparison of esophageal pH and multichannel intraluminal impedance testing in pediatric patients with suspected gastroesophageal reflux. Journal of Pediatric Gastroenterology and Nutrition, 50(2), pp. 154-60. doi:10.1097/MPG.0b013e3181a4c1d8.
Francavilla R, et al. Comparison of Esophageal pH and Multichannel Intraluminal Impedance Testing in Pediatric Patients With Suspected Gastroesophageal Reflux. J Pediatr Gastroenterol Nutr. 2010;50(2):154-60. PubMed PMID: 19680154.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of esophageal pH and multichannel intraluminal impedance testing in pediatric patients with suspected gastroesophageal reflux. AU - Francavilla,Ruggiero, AU - Magistà,Anna Maria, AU - Bucci,Nunzia, AU - Villirillo,Antonietta, AU - Boscarelli,Giuseppe, AU - Mappa,Luigi, AU - Leone,Gilda, AU - Fico,Stefania, AU - Castellaneta,Stefania, AU - Indrio,Flavia, AU - Lionetti,Elena, AU - Moramarco,Fulvio, AU - Cavallo,Luciano, PY - 2009/8/15/entrez PY - 2009/8/15/pubmed PY - 2010/5/26/medline SP - 154 EP - 60 JF - Journal of pediatric gastroenterology and nutrition JO - J. Pediatr. Gastroenterol. Nutr. VL - 50 IS - 2 N2 - BACKGROUND: Multichannel intraluminal impedance (MII) is a pH-independent method of assessing gastroesophageal reflux. AIM: To evaluate the diagnostic accuracy of MII-pH as compared with conventional pH monitoring in detecting reflux events (REs) and symptom association in different age groups. METHODS: : A prospective direct comparison of 2 diagnostic techniques on 291 consecutive patients referred for suspected gastroesophageal reflux disease. Sensitivity and diagnostic accuracy of MII-pH versus pH monitoring and symptom association were measured. RESULTS: MII-pH detected 13631 REs, 6260 (46%) of which were nonacid. The prevalence of weakly acid refluxes in the 24 hours and postprandial period as well as the proximal extension of refluxate were significantly greater in infants as compared with children (P < 0.001, P < 0.001, and P < 0.01, respectively). The diagnostic accuracy of combined MII-pH in revealing all RE and acid RE were significantly higher in infants as compared with children (92% vs 82%, P < 0.01 and 83% vs 76%, P < 0.04, respectively). The addition of MII to conventional pH monitoring significantly increases the diagnostic yield of symptom association analysis in revealing an association between atypical symptoms and refluxes irrespective of age, whereas in studying typical symptoms it was true only for infants. CONCLUSIONS: Addition of MII to conventional pH monitoring significantly increases the diagnostic yield in detecting REs, prevalently in infants, and in revealing an association between refluxes and symptoms, prevalently respiratory ones and in infants group. SN - 1536-4801 UR - https://www.unboundmedicine.com/medline/citation/19680154/Comparison_of_esophageal_pH_and_multichannel_intraluminal_impedance_testing_in_pediatric_patients_with_suspected_gastroesophageal_reflux_ L2 - http://dx.doi.org/10.1097/MPG.0b013e3181a4c1d8 DB - PRIME DP - Unbound Medicine ER -