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Replication of association between a common variant near melanocortin-4 receptor gene and obesity-related traits in Asian Sikhs.
Obesity (Silver Spring) 2010; 18(2):425-9O

Abstract

Recent genome-wide association studies (GWAS) in Asian Indians reported strong associations of variants near melanocortin-4 receptor (MC4R) and MLX interacting protein-like (MLXIPL) genes with insulin resistance and several obesity-related quantitative traits (QTs). Here, we evaluated the association of two variants (rs12970134 and rs4450508) near MC4R and a nonsynonymous (Gln241His) variant (rs3812316) in MLXIPL gene with type 2 diabetes (T2D) and obesity-related QTs in our case-control cohort (n = 1,528; 745 T2D cases and 783 controls) from a Sikh population from North India. We have successfully replicated the association of MC4R (rs12970134) with BMI (P = 0.0005), total weight (WT) (P = 0.001), and waist circumference (WC) (P = 0.001). These associations remained significant after controlling for multiple testing by applying Bonferroni's correction. However, our data did not confirm the association of rs3812316 in the MLXIPL gene with triglyceride (TG) levels. These observations demonstrate that the genetic variation in MC4R locus can have a moderate contribution in the regional fat deposition and development of central obesity in Asian Indians.

Authors+Show Affiliations

Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19680233

Citation

Been, Latonya F., et al. "Replication of Association Between a Common Variant Near Melanocortin-4 Receptor Gene and Obesity-related Traits in Asian Sikhs." Obesity (Silver Spring, Md.), vol. 18, no. 2, 2010, pp. 425-9.
Been LF, Nath SK, Ralhan SK, et al. Replication of association between a common variant near melanocortin-4 receptor gene and obesity-related traits in Asian Sikhs. Obesity (Silver Spring). 2010;18(2):425-9.
Been, L. F., Nath, S. K., Ralhan, S. K., Wander, G. S., Mehra, N. K., Singh, J., ... Sanghera, D. K. (2010). Replication of association between a common variant near melanocortin-4 receptor gene and obesity-related traits in Asian Sikhs. Obesity (Silver Spring, Md.), 18(2), pp. 425-9. doi:10.1038/oby.2009.254.
Been LF, et al. Replication of Association Between a Common Variant Near Melanocortin-4 Receptor Gene and Obesity-related Traits in Asian Sikhs. Obesity (Silver Spring). 2010;18(2):425-9. PubMed PMID: 19680233.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Replication of association between a common variant near melanocortin-4 receptor gene and obesity-related traits in Asian Sikhs. AU - Been,Latonya F, AU - Nath,Swapan K, AU - Ralhan,Sarju K, AU - Wander,Gurpreet S, AU - Mehra,Narinder K, AU - Singh,Jairup, AU - Mulvihill,John J, AU - Sanghera,Dharambir K, Y1 - 2009/08/13/ PY - 2009/8/15/entrez PY - 2009/8/15/pubmed PY - 2010/2/23/medline SP - 425 EP - 9 JF - Obesity (Silver Spring, Md.) JO - Obesity (Silver Spring) VL - 18 IS - 2 N2 - Recent genome-wide association studies (GWAS) in Asian Indians reported strong associations of variants near melanocortin-4 receptor (MC4R) and MLX interacting protein-like (MLXIPL) genes with insulin resistance and several obesity-related quantitative traits (QTs). Here, we evaluated the association of two variants (rs12970134 and rs4450508) near MC4R and a nonsynonymous (Gln241His) variant (rs3812316) in MLXIPL gene with type 2 diabetes (T2D) and obesity-related QTs in our case-control cohort (n = 1,528; 745 T2D cases and 783 controls) from a Sikh population from North India. We have successfully replicated the association of MC4R (rs12970134) with BMI (P = 0.0005), total weight (WT) (P = 0.001), and waist circumference (WC) (P = 0.001). These associations remained significant after controlling for multiple testing by applying Bonferroni's correction. However, our data did not confirm the association of rs3812316 in the MLXIPL gene with triglyceride (TG) levels. These observations demonstrate that the genetic variation in MC4R locus can have a moderate contribution in the regional fat deposition and development of central obesity in Asian Indians. SN - 1930-739X UR - https://www.unboundmedicine.com/medline/citation/19680233/Replication_of_association_between_a_common_variant_near_melanocortin_4_receptor_gene_and_obesity_related_traits_in_Asian_Sikhs_ L2 - https://doi.org/10.1038/oby.2009.254 DB - PRIME DP - Unbound Medicine ER -