Tags

Type your tag names separated by a space and hit enter

Physical activity and the risk of breast cancer in BRCA1/2 mutation carriers.
Breast Cancer Res Treat 2010; 120(1):235-44BC

Abstract

BRCA1/2 mutation carriers have a high lifetime risk of developing breast cancer. Differences in penetrance indicate that this risk may be influenced by lifestyle factors. Because physical activity is one of the few modifiable risk factors, it may provide a target to add to breast cancer prevention in this high-risk population. We examined the association between self-reported lifetime sports activity and breast cancer risk in a nationwide retrospective cohort study, including 725 carriers, of whom 218 had been diagnosed with breast cancer within 10 years prior to questionnaire completion. We found a nonsignificantly decreased risk for ever engaging in sports activity (HR = 0.84, 95%CI = 0.57-1.24). Among women who had participated in sports, a medium versus low level of intensity and duration (i.e., between 11.0 and 22.7 mean MET hours/week averaged over a lifetime) reduced the risk of breast cancer (HR = 0.59, 95%CI = 0.36-0.95); no dose-response trend was observed. For mean hours/week of sports activity, a nonsignificant trend was observed (HR(low versus never) = 0.93, 95%CI = 0.60-1.43; HR(medium versus never) = 0.81, 95%CI = 0.51-1.29; HR(high versus never) = 0.78, 95%CI = 0.48-1.29; p (trend overall) = 0.272; p (trend active women) = 0.487). For number of years of sports activity no significant associations were found. Among women active in sports before age 30, mean MET hours/week showed the strongest inverse association of all activity measures (HR(medium versus low) = 0.60, 95%CI = 0.38-0.96; HR(high versus low) = 0.58, 95%CI = 0.35-0.94; p (trend) = 0.053). Engaging in sports activity after age 30 was also inversely associated with breast cancer risk (HR = 0.63, 95%CI = 0.44-0.91). Our results indicate that sports activity may reduce the risk of breast cancer in BRCA1/2 mutation carriers.

Authors+Show Affiliations

Department of Epidemiology, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands. a.pijpe@nki.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19680614

Citation

Pijpe, Anouk, et al. "Physical Activity and the Risk of Breast Cancer in BRCA1/2 Mutation Carriers." Breast Cancer Research and Treatment, vol. 120, no. 1, 2010, pp. 235-44.
Pijpe A, Manders P, Brohet RM, et al. Physical activity and the risk of breast cancer in BRCA1/2 mutation carriers. Breast Cancer Res Treat. 2010;120(1):235-44.
Pijpe, A., Manders, P., Brohet, R. M., Collée, J. M., Verhoef, S., Vasen, H. F., ... Rookus, M. A. (2010). Physical activity and the risk of breast cancer in BRCA1/2 mutation carriers. Breast Cancer Research and Treatment, 120(1), pp. 235-44. doi:10.1007/s10549-009-0476-0.
Pijpe A, et al. Physical Activity and the Risk of Breast Cancer in BRCA1/2 Mutation Carriers. Breast Cancer Res Treat. 2010;120(1):235-44. PubMed PMID: 19680614.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Physical activity and the risk of breast cancer in BRCA1/2 mutation carriers. AU - Pijpe,Anouk, AU - Manders,Peggy, AU - Brohet,Richard M, AU - Collée,J Margriet, AU - Verhoef,Senno, AU - Vasen,Hans F A, AU - Hoogerbrugge,Nicoline, AU - van Asperen,Christi J, AU - Dommering,Charlotte, AU - Ausems,Margreet G E M, AU - Aalfs,Cora M, AU - Gomez-Garcia,Encarna B, AU - ,, AU - Van't Veer,Laura J, AU - van Leeuwen,Flora E, AU - Rookus,Matti A, Y1 - 2009/08/13/ PY - 2009/07/07/received PY - 2009/07/10/accepted PY - 2009/8/15/entrez PY - 2009/8/15/pubmed PY - 2010/3/24/medline SP - 235 EP - 44 JF - Breast cancer research and treatment JO - Breast Cancer Res. Treat. VL - 120 IS - 1 N2 - BRCA1/2 mutation carriers have a high lifetime risk of developing breast cancer. Differences in penetrance indicate that this risk may be influenced by lifestyle factors. Because physical activity is one of the few modifiable risk factors, it may provide a target to add to breast cancer prevention in this high-risk population. We examined the association between self-reported lifetime sports activity and breast cancer risk in a nationwide retrospective cohort study, including 725 carriers, of whom 218 had been diagnosed with breast cancer within 10 years prior to questionnaire completion. We found a nonsignificantly decreased risk for ever engaging in sports activity (HR = 0.84, 95%CI = 0.57-1.24). Among women who had participated in sports, a medium versus low level of intensity and duration (i.e., between 11.0 and 22.7 mean MET hours/week averaged over a lifetime) reduced the risk of breast cancer (HR = 0.59, 95%CI = 0.36-0.95); no dose-response trend was observed. For mean hours/week of sports activity, a nonsignificant trend was observed (HR(low versus never) = 0.93, 95%CI = 0.60-1.43; HR(medium versus never) = 0.81, 95%CI = 0.51-1.29; HR(high versus never) = 0.78, 95%CI = 0.48-1.29; p (trend overall) = 0.272; p (trend active women) = 0.487). For number of years of sports activity no significant associations were found. Among women active in sports before age 30, mean MET hours/week showed the strongest inverse association of all activity measures (HR(medium versus low) = 0.60, 95%CI = 0.38-0.96; HR(high versus low) = 0.58, 95%CI = 0.35-0.94; p (trend) = 0.053). Engaging in sports activity after age 30 was also inversely associated with breast cancer risk (HR = 0.63, 95%CI = 0.44-0.91). Our results indicate that sports activity may reduce the risk of breast cancer in BRCA1/2 mutation carriers. SN - 1573-7217 UR - https://www.unboundmedicine.com/medline/citation/19680614/Physical_activity_and_the_risk_of_breast_cancer_in_BRCA1/2_mutation_carriers_ L2 - https://doi.org/10.1007/s10549-009-0476-0 DB - PRIME DP - Unbound Medicine ER -