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Clinical trial of tooth whitening with 6% hydrogen peroxide whitening strips and two whitening dentifrices.
Am J Dent. 2007 Sep; 20 Spec No A:32A-36A.AJ

Abstract

PURPOSE

To compare tooth whitening with 6% hydrogen peroxide whitening strips and two whitening dentifrices in a 12-week randomized controlled trial at a Belgian dental school.

METHODS

After informed consent, 46 healthy adults were randomly assigned to one of three strip + dentifrice treatment groups. Subjects received either 6% hydrogen peroxide whitening strips (Crest Whitestrips) and an anticavity toothpaste (Crest Cavity Protection), placebo strips and a sodium fluoride (NaF) whitening dentifrice (Mentadent Whitening Toothpaste) or placebo strips and a sodium monofluorophosphate (MFP) whitening dentifrice (Rembrandt Low Abrasion Whitening Toothpaste). Strip use (peroxide or placebo) was for 30 minutes, twice daily for 2 weeks, while dentifrice use was at least twice daily for 12 weeks. Efficacy was measured from standardized digital images of the maxillary facial tooth surfaces, while safety was evaluated from oral examination and interview. Treatments were compared after 2 weeks (strip use) and 12 weeks (dentifrice use) using analysis of covariance.

RESULTS

All subjects completed the 12-week evaluation. Adjusting for baseline and age, the peroxide strip group had -2.45 Deltab*, 2.39 DeltaL*, and -0.96 Deltaa* at Week 2. Between-group comparisons demonstrated significant (P< 0.0001) reductions in yellowness and redness, and increased brightness favoring the peroxide strip group. The peroxide strip group demonstrated 95%+ color retention (Deltab* & DeltaL*) at Week 12, differing significantly (P< 0.0001) versus either of the continuously used whitening dentifrices. There were no significant (P> 0.18) differences between the whitening dentifrice groups at any timepoints. All treatments were well-tolerated, with minor tooth sensitivity and oral irritation representing the most common findings.

Authors+Show Affiliations

Catholic University of Leuven, Departement Tandheelkunde, Mondziekten en Kaakchirurgie, UZ Sint-Rafael, Leuven, Belgium. Rafael.Yudhira@med.kuleuven.beNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19681257

Citation

Yudhira, Rafael, et al. "Clinical Trial of Tooth Whitening With 6% Hydrogen Peroxide Whitening Strips and Two Whitening Dentifrices." American Journal of Dentistry, vol. 20 Spec No A, 2007, 32A-36A.
Yudhira R, Peumans M, Barker ML, et al. Clinical trial of tooth whitening with 6% hydrogen peroxide whitening strips and two whitening dentifrices. Am J Dent. 2007;20 Spec No A:32A-36A.
Yudhira, R., Peumans, M., Barker, M. L., & Gerlach, R. W. (2007). Clinical trial of tooth whitening with 6% hydrogen peroxide whitening strips and two whitening dentifrices. American Journal of Dentistry, 20 Spec No A, 32A-36A.
Yudhira R, et al. Clinical Trial of Tooth Whitening With 6% Hydrogen Peroxide Whitening Strips and Two Whitening Dentifrices. Am J Dent. 2007;20 Spec No A:32A-36A. PubMed PMID: 19681257.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical trial of tooth whitening with 6% hydrogen peroxide whitening strips and two whitening dentifrices. AU - Yudhira,Rafael, AU - Peumans,Marleen, AU - Barker,Matthew L, AU - Gerlach,Robert W, PY - 2009/8/18/entrez PY - 2007/9/1/pubmed PY - 2009/9/16/medline SP - 32A EP - 36A JF - American journal of dentistry JO - Am J Dent VL - 20 Spec No A N2 - PURPOSE: To compare tooth whitening with 6% hydrogen peroxide whitening strips and two whitening dentifrices in a 12-week randomized controlled trial at a Belgian dental school. METHODS: After informed consent, 46 healthy adults were randomly assigned to one of three strip + dentifrice treatment groups. Subjects received either 6% hydrogen peroxide whitening strips (Crest Whitestrips) and an anticavity toothpaste (Crest Cavity Protection), placebo strips and a sodium fluoride (NaF) whitening dentifrice (Mentadent Whitening Toothpaste) or placebo strips and a sodium monofluorophosphate (MFP) whitening dentifrice (Rembrandt Low Abrasion Whitening Toothpaste). Strip use (peroxide or placebo) was for 30 minutes, twice daily for 2 weeks, while dentifrice use was at least twice daily for 12 weeks. Efficacy was measured from standardized digital images of the maxillary facial tooth surfaces, while safety was evaluated from oral examination and interview. Treatments were compared after 2 weeks (strip use) and 12 weeks (dentifrice use) using analysis of covariance. RESULTS: All subjects completed the 12-week evaluation. Adjusting for baseline and age, the peroxide strip group had -2.45 Deltab*, 2.39 DeltaL*, and -0.96 Deltaa* at Week 2. Between-group comparisons demonstrated significant (P< 0.0001) reductions in yellowness and redness, and increased brightness favoring the peroxide strip group. The peroxide strip group demonstrated 95%+ color retention (Deltab* & DeltaL*) at Week 12, differing significantly (P< 0.0001) versus either of the continuously used whitening dentifrices. There were no significant (P> 0.18) differences between the whitening dentifrice groups at any timepoints. All treatments were well-tolerated, with minor tooth sensitivity and oral irritation representing the most common findings. SN - 0894-8275 UR - https://www.unboundmedicine.com/medline/citation/19681257/Clinical_trial_of_tooth_whitening_with_6_hydrogen_peroxide_whitening_strips_and_two_whitening_dentifrices_ L2 - https://www.lens.org/lens/search/patent/list?q=citation_id:19681257 DB - PRIME DP - Unbound Medicine ER -