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Potency of mephentermine for prevention of post-spinal hypotension.
Anaesth Intensive Care. 2009 Jul; 37(4):568-70.AI

Abstract

This study was designed to determine the minimum effective dose (ED50) of mephentermine for prevention of post-spinal hypotension in women undergoing elective caesarean section. Dixon's up-down method of sequential allocation was used to determine the patient's dose of vasopressor drug. In our previous study, mephentermine appeared to be much more potent than ephedrine, so the present study was conducted using a lower initial dose and smaller dose interval for this vasopressor. Following administration of spinal anaesthesia, a prophylactic infusion of mephentermine was started with 5 mg infused over a period of 30 minutes as the initial dose and a dose interval of 1 mg. The ED50 of mephentermine of 3.7 mg (95% confidence interval 2.4 to 5.7 mg) was much less than that of ephedrine, as calculated in our previous study using the same methodology. Using these values gives a potency ratio of ephedrine to mephentermine of 1:6.8 (95% confidence interval 6.0 to 7.5).

Authors+Show Affiliations

Department of Anaesthesiology and Critical Care, University College of Medical Sciences, Delhi, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19681412

Citation

Mohta, M, et al. "Potency of Mephentermine for Prevention of Post-spinal Hypotension." Anaesthesia and Intensive Care, vol. 37, no. 4, 2009, pp. 568-70.
Mohta M, Agarwal D, Gupta LK, et al. Potency of mephentermine for prevention of post-spinal hypotension. Anaesth Intensive Care. 2009;37(4):568-70.
Mohta, M., Agarwal, D., Gupta, L. K., Sethi, A. K., & Tyagi, A. (2009). Potency of mephentermine for prevention of post-spinal hypotension. Anaesthesia and Intensive Care, 37(4), 568-70.
Mohta M, et al. Potency of Mephentermine for Prevention of Post-spinal Hypotension. Anaesth Intensive Care. 2009;37(4):568-70. PubMed PMID: 19681412.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Potency of mephentermine for prevention of post-spinal hypotension. AU - Mohta,M, AU - Agarwal,D, AU - Gupta,L K, AU - Sethi,A K, AU - Tyagi,A, PY - 2009/8/18/entrez PY - 2009/8/18/pubmed PY - 2009/9/2/medline SP - 568 EP - 70 JF - Anaesthesia and intensive care JO - Anaesth Intensive Care VL - 37 IS - 4 N2 - This study was designed to determine the minimum effective dose (ED50) of mephentermine for prevention of post-spinal hypotension in women undergoing elective caesarean section. Dixon's up-down method of sequential allocation was used to determine the patient's dose of vasopressor drug. In our previous study, mephentermine appeared to be much more potent than ephedrine, so the present study was conducted using a lower initial dose and smaller dose interval for this vasopressor. Following administration of spinal anaesthesia, a prophylactic infusion of mephentermine was started with 5 mg infused over a period of 30 minutes as the initial dose and a dose interval of 1 mg. The ED50 of mephentermine of 3.7 mg (95% confidence interval 2.4 to 5.7 mg) was much less than that of ephedrine, as calculated in our previous study using the same methodology. Using these values gives a potency ratio of ephedrine to mephentermine of 1:6.8 (95% confidence interval 6.0 to 7.5). SN - 0310-057X UR - https://www.unboundmedicine.com/medline/citation/19681412/Potency_of_mephentermine_for_prevention_of_post_spinal_hypotension_ L2 - http://journals.sagepub.com/doi/full/10.1177/0310057X0903700417?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -