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[Expression of chosen chemokine receptors on the Th lymphocytes in children with hypertrophied adenoids with otitis media with effusion].
Otolaryngol Pol. 2009 Mar-Apr; 63(2):131-5.OP

Abstract

INTRODUCTION

Chemokine receptors play a crucial role in the recruitment of leucocytes into inflamed tissue from secondary lymphoid organs.

AIM OF THIS STUDY

was evaluation of the percentage Th (CD4+) lymphocytes with expression of chemokine receptors: CCR3, CCR4, and CCR5 in hypertrophied adenois tissue in children with otitis media with effusion.

MATERIAL AND METHODS

36 children with otitis media with effusion and 25 children with hypertrophied adenoids were tested. Expression of chemokine receptors CCR3, CCR4 and CCR5 on T CD4 lymphocytes of hypertrophied adenoid's tissue was estimated by flow cytometry method.

RESULTS

Average percentage of T CD4+ lymphocytes with expression CCR4 in hypertrophied adenoid in children group with otitis media with effusion (OME = 64.11%) was significantly higher than in comparative group with hypertrophied adenoid (HA = 75.05%, p < 0.04). We showed statistically lower percentage of CD3+CD4+ cells with expression CCR3 in examinated group (OME = 47.19%) than HA group (62.66%; p < 0.003).

CONCLUSION

Results suggests that intensify of humoral immunological answer in hypertrophied adenoid depends on Th2 lymphocytes with expression CCR3 and CCR4 chemokine receptors in course of inflammatory state in middle ear.

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Authors+Show Affiliations

Ratomski K
Zakład Laboratoryjnej Diagnostyki Pediatrycznej, Uniwersytet Medyczny w Białymstoku. karol.cam@interia.pl
Wysocka J
No affiliation info available
Skotnicka B
No affiliation info available
Kasprzycka E
No affiliation info available
Zelazowska-Rutkowska B
No affiliation info available
Zak J
No affiliation info available
Hassmann-Poznańska E
No affiliation info available

MeSH

AdenoidsAdolescentBiomarkersCD4-Positive T-LymphocytesChildChild, PreschoolFemaleFlow CytometryHumansHypertrophyInfantMaleOtitis Media with EffusionReceptors, CCRReceptors, CCR3Receptors, CCR4Receptors, CCR5Severity of Illness IndexStatistics, Nonparametric

Pub Type(s)

Comparative Study
English Abstract
Journal Article

Language

pol

PubMed ID

19681483

Citation

Ratomski, Karol, et al. "[Expression of Chosen Chemokine Receptors On the Th Lymphocytes in Children With Hypertrophied Adenoids With Otitis Media With Effusion]." Otolaryngologia Polska = the Polish Otolaryngology, vol. 63, no. 2, 2009, pp. 131-5.
Ratomski K, Wysocka J, Skotnicka B, et al. [Expression of chosen chemokine receptors on the Th lymphocytes in children with hypertrophied adenoids with otitis media with effusion]. Otolaryngol Pol. 2009;63(2):131-5.
Ratomski, K., Wysocka, J., Skotnicka, B., Kasprzycka, E., Zelazowska-Rutkowska, B., Zak, J., & Hassmann-Poznańska, E. (2009). [Expression of chosen chemokine receptors on the Th lymphocytes in children with hypertrophied adenoids with otitis media with effusion]. Otolaryngologia Polska = the Polish Otolaryngology, 63(2), 131-5. https://doi.org/10.1016/S0030-6657(09)70093-9
Ratomski K, et al. [Expression of Chosen Chemokine Receptors On the Th Lymphocytes in Children With Hypertrophied Adenoids With Otitis Media With Effusion]. Otolaryngol Pol. 2009 Mar-Apr;63(2):131-5. PubMed PMID: 19681483.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Expression of chosen chemokine receptors on the Th lymphocytes in children with hypertrophied adenoids with otitis media with effusion]. AU - Ratomski,Karol, AU - Wysocka,Jolanta, AU - Skotnicka,Bozena, AU - Kasprzycka,Edwina, AU - Zelazowska-Rutkowska,Beata, AU - Zak,Janusz, AU - Hassmann-Poznańska,Elzbieta, PY - 2009/8/18/entrez PY - 2009/8/18/pubmed PY - 2009/9/11/medline SP - 131 EP - 5 JF - Otolaryngologia polska = The Polish otolaryngology JO - Otolaryngol Pol VL - 63 IS - 2 N2 - INTRODUCTION: Chemokine receptors play a crucial role in the recruitment of leucocytes into inflamed tissue from secondary lymphoid organs. AIM OF THIS STUDY: was evaluation of the percentage Th (CD4+) lymphocytes with expression of chemokine receptors: CCR3, CCR4, and CCR5 in hypertrophied adenois tissue in children with otitis media with effusion. MATERIAL AND METHODS: 36 children with otitis media with effusion and 25 children with hypertrophied adenoids were tested. Expression of chemokine receptors CCR3, CCR4 and CCR5 on T CD4 lymphocytes of hypertrophied adenoid's tissue was estimated by flow cytometry method. RESULTS: Average percentage of T CD4+ lymphocytes with expression CCR4 in hypertrophied adenoid in children group with otitis media with effusion (OME = 64.11%) was significantly higher than in comparative group with hypertrophied adenoid (HA = 75.05%, p < 0.04). We showed statistically lower percentage of CD3+CD4+ cells with expression CCR3 in examinated group (OME = 47.19%) than HA group (62.66%; p < 0.003). CONCLUSION: Results suggests that intensify of humoral immunological answer in hypertrophied adenoid depends on Th2 lymphocytes with expression CCR3 and CCR4 chemokine receptors in course of inflammatory state in middle ear. SN - 0030-6657 UR - https://www.unboundmedicine.com/medline/citation/19681483/[Expression_of_chosen_chemokine_receptors_on_the_Th_lymphocytes_in_children_with_hypertrophied_adenoids_with_otitis_media_with_effusion]_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0030-6657(09)70093-9 DB - PRIME DP - Unbound Medicine ER -