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Microencapsulation of isoniazid in genipin-crosslinked gelatin-A-κ-carrageenan polyelectrolyte complex.
Drug Dev Ind Pharm. 2010 Jan; 36(1):56-63.DD

Abstract

BACKGROUND

Microspheres of gelatin-A and κ-carrageenan were prepared by using genipin, a naturally occurring crosslinker, and sunflower oil as reaction media.

METHOD

The variations in the size of the microspheres formed by varying the amount of surfactant (0.33-1.0 g/g of polymer), polymer (1.5-3.0 g), and crosslinker (0.2-0.8 mmol) were studied by scanning electron microscopy. The encapsulation of isoniazid was carried out by absorption. The isoniazid content in the prepared microspheres was determined. The release characteristic of isoniazid was also studied at pH values 1.2 and 7.4 by using UV-spectrophotometer.

RESULTS

Characterization of the isoniazid-loaded microspheres was carried out by using Fourier transform infrared spectrophotometry, differential scanning calorimetry, and X-ray diffractometery.

Authors+Show Affiliations

Department of Chemical Sciences, Tezpur University, Napaam, Assam, India.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19681667

Citation

Devi, Nirmala, and Tarun K. Maji. "Microencapsulation of Isoniazid in Genipin-crosslinked gelatin-A-κ-carrageenan Polyelectrolyte Complex." Drug Development and Industrial Pharmacy, vol. 36, no. 1, 2010, pp. 56-63.
Devi N, Maji TK. Microencapsulation of isoniazid in genipin-crosslinked gelatin-A-κ-carrageenan polyelectrolyte complex. Drug Dev Ind Pharm. 2010;36(1):56-63.
Devi, N., & Maji, T. K. (2010). Microencapsulation of isoniazid in genipin-crosslinked gelatin-A-κ-carrageenan polyelectrolyte complex. Drug Development and Industrial Pharmacy, 36(1), 56-63. https://doi.org/10.3109/03639040903061355
Devi N, Maji TK. Microencapsulation of Isoniazid in Genipin-crosslinked gelatin-A-κ-carrageenan Polyelectrolyte Complex. Drug Dev Ind Pharm. 2010;36(1):56-63. PubMed PMID: 19681667.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Microencapsulation of isoniazid in genipin-crosslinked gelatin-A-κ-carrageenan polyelectrolyte complex. AU - Devi,Nirmala, AU - Maji,Tarun K, PY - 2009/8/18/entrez PY - 2009/8/18/pubmed PY - 2012/10/30/medline SP - 56 EP - 63 JF - Drug development and industrial pharmacy JO - Drug Dev Ind Pharm VL - 36 IS - 1 N2 - BACKGROUND: Microspheres of gelatin-A and κ-carrageenan were prepared by using genipin, a naturally occurring crosslinker, and sunflower oil as reaction media. METHOD: The variations in the size of the microspheres formed by varying the amount of surfactant (0.33-1.0 g/g of polymer), polymer (1.5-3.0 g), and crosslinker (0.2-0.8 mmol) were studied by scanning electron microscopy. The encapsulation of isoniazid was carried out by absorption. The isoniazid content in the prepared microspheres was determined. The release characteristic of isoniazid was also studied at pH values 1.2 and 7.4 by using UV-spectrophotometer. RESULTS: Characterization of the isoniazid-loaded microspheres was carried out by using Fourier transform infrared spectrophotometry, differential scanning calorimetry, and X-ray diffractometery. SN - 1520-5762 UR - https://www.unboundmedicine.com/medline/citation/19681667/Microencapsulation_of_isoniazid_in_genipin_crosslinked_gelatin_A_κ_carrageenan_polyelectrolyte_complex_ L2 - http://www.tandfonline.com/doi/full/10.3109/03639040903061355 DB - PRIME DP - Unbound Medicine ER -