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Encephalopathy with status epilepticus during slow sleep: "the Penelope syndrome".
Epilepsia. 2009 Aug; 50 Suppl 7:4-8.E

Abstract

ESES (encephalopathy with status epilepticus during sleep) is an epileptic encephalopathy with heterogeneous clinical manifestations (cognitive, motor, and behavioral disturbances in different associations, and various seizure types) related to a peculiar electroencephalography (EEG) pattern characterized by paroxysmal activity significantly activated during slow sleep-that is, a condition of continuous spikes and waves, or status epilepticus, during sleep. The pathophysiologic mechanisms underlying this condition are still incompletely understood; recent data suggest that the abnormal epileptic EEG activity occurring during sleep might cause the typical clinical symptoms by interfering with sleep-related physiologic functions, and possibly neuroplasticity processes mediating higher cortical functions such as learning and memory consolidation. As in the myth of Penelope, the wife of Odysseus, what is weaved during the day will be unraveled during the night.

Authors+Show Affiliations

Department of Neurological Sciences, University of Bologna, Bologna, Italy. carlo.tassinari@unibo.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

19682041

Citation

Tassinari, Carlo A., et al. "Encephalopathy With Status Epilepticus During Slow Sleep: "the Penelope Syndrome"." Epilepsia, vol. 50 Suppl 7, 2009, pp. 4-8.
Tassinari CA, Cantalupo G, Rios-Pohl L, et al. Encephalopathy with status epilepticus during slow sleep: "the Penelope syndrome". Epilepsia. 2009;50 Suppl 7:4-8.
Tassinari, C. A., Cantalupo, G., Rios-Pohl, L., Giustina, E. D., & Rubboli, G. (2009). Encephalopathy with status epilepticus during slow sleep: "the Penelope syndrome". Epilepsia, 50 Suppl 7, 4-8. https://doi.org/10.1111/j.1528-1167.2009.02209.x
Tassinari CA, et al. Encephalopathy With Status Epilepticus During Slow Sleep: "the Penelope Syndrome". Epilepsia. 2009;50 Suppl 7:4-8. PubMed PMID: 19682041.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Encephalopathy with status epilepticus during slow sleep: "the Penelope syndrome". AU - Tassinari,Carlo A, AU - Cantalupo,Gaetano, AU - Rios-Pohl,Loreto, AU - Giustina,Elvio Della, AU - Rubboli,Guido, PY - 2009/8/18/entrez PY - 2009/8/18/pubmed PY - 2009/9/12/medline SP - 4 EP - 8 JF - Epilepsia JO - Epilepsia VL - 50 Suppl 7 N2 - ESES (encephalopathy with status epilepticus during sleep) is an epileptic encephalopathy with heterogeneous clinical manifestations (cognitive, motor, and behavioral disturbances in different associations, and various seizure types) related to a peculiar electroencephalography (EEG) pattern characterized by paroxysmal activity significantly activated during slow sleep-that is, a condition of continuous spikes and waves, or status epilepticus, during sleep. The pathophysiologic mechanisms underlying this condition are still incompletely understood; recent data suggest that the abnormal epileptic EEG activity occurring during sleep might cause the typical clinical symptoms by interfering with sleep-related physiologic functions, and possibly neuroplasticity processes mediating higher cortical functions such as learning and memory consolidation. As in the myth of Penelope, the wife of Odysseus, what is weaved during the day will be unraveled during the night. SN - 1528-1167 UR - https://www.unboundmedicine.com/medline/citation/19682041/Encephalopathy_with_status_epilepticus_during_slow_sleep:_"the_Penelope_syndrome"_ L2 - https://doi.org/10.1111/j.1528-1167.2009.02209.x DB - PRIME DP - Unbound Medicine ER -