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Assessment of changes in the epidemiology of Clostridium difficile isolated from diarrheal patients in Hungary.
Anaerobe. 2009 Dec; 15(6):237-40.A

Abstract

150 Clostridium difficile strains isolated from diarrheal feces were collected from three parts of Hungary and the presence of genes responsible for toxin A and B, and binary toxin production were examined. MIC distribution against clindamycin, erythromycin, metronidazole, moxifloxacin and rifampin of 80 toxigenic strains selected from the above-mentioned strains and 20 large clostridial toxins (LCTs)-positive strains chosen from our earlier strain collection were determined. 80% of the examined 150 strains were positive for both tcdA and tcdB, and no toxin A-negative, toxin B-positive isolates were found during the study period. 5.3% of toxigenic strains proved to be positive for binary toxin too. Among binary toxin-positive strains, one strain showed the same pattern characteristic of PCR ribotype 027. Comparison of recent findings and our earlier results, the prevalence of toxin-producing and binary toxin-positive strains among C. difficile isolated from diarrheal specimens increased. No metronidazole resistant isolate was detected among strains isolated in 2002-2003 and 2006-2007. The rates of resistance to erythromycin, clindamycin, moxifloxacin and rifampin among strains isolated between 2006 and 2007 were 25%, 27.5%, 25% and 6.3%, respectively. Erythromycin resistance was frequently associated with clindamycin and moxifloxacin resistance, however this resistant phenotype was not found among strains isolated in 2002-2003.

Authors+Show Affiliations

Institute of Clinical Microbiology, Faculty of Medicine, University of Szeged, H-6725 Szeged, Semmelweis u 6, Hungary. terhesga@freemail.huNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19682411

Citation

Terhes, Gabriella, et al. "Assessment of Changes in the Epidemiology of Clostridium Difficile Isolated From Diarrheal Patients in Hungary." Anaerobe, vol. 15, no. 6, 2009, pp. 237-40.
Terhes G, Urbán E, Sóki J, et al. Assessment of changes in the epidemiology of Clostridium difficile isolated from diarrheal patients in Hungary. Anaerobe. 2009;15(6):237-40.
Terhes, G., Urbán, E., Sóki, J., Szikra, L., Konkoly-Thege, M., Vollain, M., & Nagy, E. (2009). Assessment of changes in the epidemiology of Clostridium difficile isolated from diarrheal patients in Hungary. Anaerobe, 15(6), 237-40. https://doi.org/10.1016/j.anaerobe.2009.01.010
Terhes G, et al. Assessment of Changes in the Epidemiology of Clostridium Difficile Isolated From Diarrheal Patients in Hungary. Anaerobe. 2009;15(6):237-40. PubMed PMID: 19682411.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Assessment of changes in the epidemiology of Clostridium difficile isolated from diarrheal patients in Hungary. AU - Terhes,Gabriella, AU - Urbán,Edit, AU - Sóki,József, AU - Szikra,Lenke, AU - Konkoly-Thege,Marianne, AU - Vollain,Mária, AU - Nagy,Elisabeth, Y1 - 2009/02/09/ PY - 2008/10/05/received PY - 2009/01/14/revised PY - 2009/01/27/accepted PY - 2009/8/18/entrez PY - 2009/8/18/pubmed PY - 2010/2/13/medline SP - 237 EP - 40 JF - Anaerobe JO - Anaerobe VL - 15 IS - 6 N2 - 150 Clostridium difficile strains isolated from diarrheal feces were collected from three parts of Hungary and the presence of genes responsible for toxin A and B, and binary toxin production were examined. MIC distribution against clindamycin, erythromycin, metronidazole, moxifloxacin and rifampin of 80 toxigenic strains selected from the above-mentioned strains and 20 large clostridial toxins (LCTs)-positive strains chosen from our earlier strain collection were determined. 80% of the examined 150 strains were positive for both tcdA and tcdB, and no toxin A-negative, toxin B-positive isolates were found during the study period. 5.3% of toxigenic strains proved to be positive for binary toxin too. Among binary toxin-positive strains, one strain showed the same pattern characteristic of PCR ribotype 027. Comparison of recent findings and our earlier results, the prevalence of toxin-producing and binary toxin-positive strains among C. difficile isolated from diarrheal specimens increased. No metronidazole resistant isolate was detected among strains isolated in 2002-2003 and 2006-2007. The rates of resistance to erythromycin, clindamycin, moxifloxacin and rifampin among strains isolated between 2006 and 2007 were 25%, 27.5%, 25% and 6.3%, respectively. Erythromycin resistance was frequently associated with clindamycin and moxifloxacin resistance, however this resistant phenotype was not found among strains isolated in 2002-2003. SN - 1095-8274 UR - https://www.unboundmedicine.com/medline/citation/19682411/Assessment_of_changes_in_the_epidemiology_of_Clostridium_difficile_isolated_from_diarrheal_patients_in_Hungary_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1075-9964(09)00027-4 DB - PRIME DP - Unbound Medicine ER -