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Cardiorespiratory fitness, lifestyle factors and cancer risk and mortality in Finnish men.
Eur J Cancer 2010; 46(2):355-63EJ

Abstract

BACKGROUND

Physical fitness along with lifestyle factors may have important roles in the prevention of cancer. We examined the relationship between common lifestyle factors such as energy expenditure, physical activity and maximal oxygen uptake (VO(2max)), nutrition and smoking habits and the risk of cancer.

METHODS

A population-based cohort study was carried out in 2268 men from Eastern Finland with no history of cancer. They were followed up for an average of 16.7 years. The outcome measures were cancer incidence (n=387) and cancer mortality (n=159).

RESULTS

Men with VO(2max) of more than 33.2 mL/kg/min (highest tertile) had 27% (95% confidence interval (CI) 0.56-0.97) decreased cancer incidence and 37% (95% CI 0.40-0.97) reduced cancer mortality than men with VO(2max) of less than 26.9 mL/kg/min (lowest tertile) after adjustment for age, examination year, alcohol, smoking, socioeconomic status, waist-to-hip ratio and energy, fibre and fat intake. The risk reduction was mainly due to decreased risk of lung cancer in fit men. The adjusted risk of cancer was 0.73 (95% CI 0.55-0.98) among fit (VO(2max)> or =26.9 mL/kg/min) men with the total energy expenditure of physical activity over 2500 kcal/week. A total of 290 active (energy expenditure >2500 kcal and at least 2h of physical activity per week) men with a favourable lifestyle (good fitness, balanced diet and non-smoking) had an adjusted relative risk of 0.63 (95% CI 0.46-0.87) for cancer.

CONCLUSION

Favourable lifestyle including good cardiorespiratory fitness and healthy dietary habits with active and non-smoking lifestyle considerably reduces the risk of cancer.

Authors+Show Affiliations

Research Institute of Public Health, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland. sudhir.kurl@uku.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19683431

Citation

Laukkanen, Jari A., et al. "Cardiorespiratory Fitness, Lifestyle Factors and Cancer Risk and Mortality in Finnish Men." European Journal of Cancer (Oxford, England : 1990), vol. 46, no. 2, 2010, pp. 355-63.
Laukkanen JA, Pukkala E, Rauramaa R, et al. Cardiorespiratory fitness, lifestyle factors and cancer risk and mortality in Finnish men. Eur J Cancer. 2010;46(2):355-63.
Laukkanen, J. A., Pukkala, E., Rauramaa, R., Mäkikallio, T. H., Toriola, A. T., & Kurl, S. (2010). Cardiorespiratory fitness, lifestyle factors and cancer risk and mortality in Finnish men. European Journal of Cancer (Oxford, England : 1990), 46(2), pp. 355-63. doi:10.1016/j.ejca.2009.07.013.
Laukkanen JA, et al. Cardiorespiratory Fitness, Lifestyle Factors and Cancer Risk and Mortality in Finnish Men. Eur J Cancer. 2010;46(2):355-63. PubMed PMID: 19683431.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cardiorespiratory fitness, lifestyle factors and cancer risk and mortality in Finnish men. AU - Laukkanen,Jari A, AU - Pukkala,Eero, AU - Rauramaa,Rainer, AU - Mäkikallio,Timo H, AU - Toriola,Adetunji T, AU - Kurl,Sudhir, Y1 - 2009/08/13/ PY - 2009/05/05/received PY - 2009/07/10/revised PY - 2009/07/17/accepted PY - 2009/8/18/entrez PY - 2009/8/18/pubmed PY - 2010/4/27/medline SP - 355 EP - 63 JF - European journal of cancer (Oxford, England : 1990) JO - Eur. J. Cancer VL - 46 IS - 2 N2 - BACKGROUND: Physical fitness along with lifestyle factors may have important roles in the prevention of cancer. We examined the relationship between common lifestyle factors such as energy expenditure, physical activity and maximal oxygen uptake (VO(2max)), nutrition and smoking habits and the risk of cancer. METHODS: A population-based cohort study was carried out in 2268 men from Eastern Finland with no history of cancer. They were followed up for an average of 16.7 years. The outcome measures were cancer incidence (n=387) and cancer mortality (n=159). RESULTS: Men with VO(2max) of more than 33.2 mL/kg/min (highest tertile) had 27% (95% confidence interval (CI) 0.56-0.97) decreased cancer incidence and 37% (95% CI 0.40-0.97) reduced cancer mortality than men with VO(2max) of less than 26.9 mL/kg/min (lowest tertile) after adjustment for age, examination year, alcohol, smoking, socioeconomic status, waist-to-hip ratio and energy, fibre and fat intake. The risk reduction was mainly due to decreased risk of lung cancer in fit men. The adjusted risk of cancer was 0.73 (95% CI 0.55-0.98) among fit (VO(2max)> or =26.9 mL/kg/min) men with the total energy expenditure of physical activity over 2500 kcal/week. A total of 290 active (energy expenditure >2500 kcal and at least 2h of physical activity per week) men with a favourable lifestyle (good fitness, balanced diet and non-smoking) had an adjusted relative risk of 0.63 (95% CI 0.46-0.87) for cancer. CONCLUSION: Favourable lifestyle including good cardiorespiratory fitness and healthy dietary habits with active and non-smoking lifestyle considerably reduces the risk of cancer. SN - 1879-0852 UR - https://www.unboundmedicine.com/medline/citation/19683431/Cardiorespiratory_fitness_lifestyle_factors_and_cancer_risk_and_mortality_in_Finnish_men_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0959-8049(09)00540-1 DB - PRIME DP - Unbound Medicine ER -