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Effect of resistance exercise on muscle steroid receptor protein content in strength-trained men and women.
Steroids. 2009 Nov-Dec; 74(13-14):1033-9.S

Abstract

The purpose of this study was to examine the acute effect of resistance exercise (RE) on muscle androgen receptor (AR) and glucocorticoid receptor (GR) protein content. Fifteen resistance-trained men (n=8; 21+/-1 years, 175.3+/-6.7 cm, 90.8+/-11.6 kg) and women (n=7; 24+/-5 years, 164.6+/-6.7 cm, 76.4+/-15.6 kg) completed 6 sets of 10 repetitions of heavy squats. Blood samples were obtained before RE, after 3 and 6 sets of squats, and 5, 15, 30 and 70 min after RE. Muscle biopsies from the vastus lateralis were obtained before RE, and 10 min and 70 min after RE. Blood samples were analyzed for total and free testosterone concentrations and muscle samples were analyzed for AR and GR protein content. Circulating total testosterone increased significantly (p< or =0.05) in men and free testosterone increased in men and women with exercise. AR was significantly reduced at 70 min post-exercise in men and at 10 min post-exercise in women compared to pre-exercise. There were no changes in GR following RE, but GR was significantly higher in women compared to men. These findings support a current paradigm for stabilization followed by a reduction and then a rebound in the acute AR response to RE but demonstrate that gender differences exist in the timeline of the AR response.

Authors+Show Affiliations

Human Performance Laboratory, Department of Kinesiology, University of Connecticut, Storrs, CT 06269, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article

Language

eng

PubMed ID

19683543

Citation

Vingren, Jakob L., et al. "Effect of Resistance Exercise On Muscle Steroid Receptor Protein Content in Strength-trained Men and Women." Steroids, vol. 74, no. 13-14, 2009, pp. 1033-9.
Vingren JL, Kraemer WJ, Hatfield DL, et al. Effect of resistance exercise on muscle steroid receptor protein content in strength-trained men and women. Steroids. 2009;74(13-14):1033-9.
Vingren, J. L., Kraemer, W. J., Hatfield, D. L., Volek, J. S., Ratamess, N. A., Anderson, J. M., Häkkinen, K., Ahtiainen, J., Fragala, M. S., Thomas, G. A., Ho, J. Y., & Maresh, C. M. (2009). Effect of resistance exercise on muscle steroid receptor protein content in strength-trained men and women. Steroids, 74(13-14), 1033-9. https://doi.org/10.1016/j.steroids.2009.08.002
Vingren JL, et al. Effect of Resistance Exercise On Muscle Steroid Receptor Protein Content in Strength-trained Men and Women. Steroids. 2009 Nov-Dec;74(13-14):1033-9. PubMed PMID: 19683543.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of resistance exercise on muscle steroid receptor protein content in strength-trained men and women. AU - Vingren,Jakob L, AU - Kraemer,William J, AU - Hatfield,Disa L, AU - Volek,Jeff S, AU - Ratamess,Nicholas A, AU - Anderson,Jeffrey M, AU - Häkkinen,Keijo, AU - Ahtiainen,Juha, AU - Fragala,Maren S, AU - Thomas,Gwendolyn A, AU - Ho,Jen-Yu, AU - Maresh,Carl M, Y1 - 2009/08/14/ PY - 2009/04/21/received PY - 2009/08/04/revised PY - 2009/08/06/accepted PY - 2009/8/18/entrez PY - 2009/8/18/pubmed PY - 2010/2/10/medline SP - 1033 EP - 9 JF - Steroids JO - Steroids VL - 74 IS - 13-14 N2 - The purpose of this study was to examine the acute effect of resistance exercise (RE) on muscle androgen receptor (AR) and glucocorticoid receptor (GR) protein content. Fifteen resistance-trained men (n=8; 21+/-1 years, 175.3+/-6.7 cm, 90.8+/-11.6 kg) and women (n=7; 24+/-5 years, 164.6+/-6.7 cm, 76.4+/-15.6 kg) completed 6 sets of 10 repetitions of heavy squats. Blood samples were obtained before RE, after 3 and 6 sets of squats, and 5, 15, 30 and 70 min after RE. Muscle biopsies from the vastus lateralis were obtained before RE, and 10 min and 70 min after RE. Blood samples were analyzed for total and free testosterone concentrations and muscle samples were analyzed for AR and GR protein content. Circulating total testosterone increased significantly (p< or =0.05) in men and free testosterone increased in men and women with exercise. AR was significantly reduced at 70 min post-exercise in men and at 10 min post-exercise in women compared to pre-exercise. There were no changes in GR following RE, but GR was significantly higher in women compared to men. These findings support a current paradigm for stabilization followed by a reduction and then a rebound in the acute AR response to RE but demonstrate that gender differences exist in the timeline of the AR response. SN - 1878-5867 UR - https://www.unboundmedicine.com/medline/citation/19683543/Effect_of_resistance_exercise_on_muscle_steroid_receptor_protein_content_in_strength_trained_men_and_women_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0039-128X(09)00183-4 DB - PRIME DP - Unbound Medicine ER -