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Antioxidant activity of 5,10-dihydroindeno[1,2-b]indoles containing substituents on dihydroindeno part.
Bioorg Med Chem. 2009 Sep 15; 17(18):6583-9.BM

Abstract

An efficient synthesis of 5,10-dihydroindeno[1,2-b]indoles (3a-t) containing substituents such as methoxy, hydroxyl, and halogen (F, Cl, and Br) on indeno part was described. Antioxidant and radical scavenging activities of synthesized compounds (3a-t) were determined by various in vitro assays such as 1,1-diphenyl-2-picryl-hydrazyl free radicals (DPPH(*)), 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid radicals (ABTS(*+)), N,N-dimethyl-p-phenylenediamine dihydrochloride radicals (DMPD(*+)), and superoxide anion radicals (O(2)(*-)) scavenging, reducing ability determination by the Fe(3+)-Fe(2+) and Cu(2+)-Cu(+) (CUPRAC method) transformation methods, H(2)O(2) scavenging, and ferrous ion (Fe(2+)) chelating activities. Moreover, these activities were compared to synthetic and standard antioxidants such as butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), alpha-tocopherol, and trolox. The results showed that the synthesized compounds (3a-t) had effective antioxidant power.

Authors+Show Affiliations

Department of Chemistry, Faculty of Sciences, Atatürk University, 25240-Erzurum, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19683932

Citation

Talaz, Oktay, et al. "Antioxidant Activity of 5,10-dihydroindeno[1,2-b]indoles Containing Substituents On Dihydroindeno Part." Bioorganic & Medicinal Chemistry, vol. 17, no. 18, 2009, pp. 6583-9.
Talaz O, Gülçin I, Göksu S, et al. Antioxidant activity of 5,10-dihydroindeno[1,2-b]indoles containing substituents on dihydroindeno part. Bioorg Med Chem. 2009;17(18):6583-9.
Talaz, O., Gülçin, I., Göksu, S., & Saracoglu, N. (2009). Antioxidant activity of 5,10-dihydroindeno[1,2-b]indoles containing substituents on dihydroindeno part. Bioorganic & Medicinal Chemistry, 17(18), 6583-9. https://doi.org/10.1016/j.bmc.2009.07.077
Talaz O, et al. Antioxidant Activity of 5,10-dihydroindeno[1,2-b]indoles Containing Substituents On Dihydroindeno Part. Bioorg Med Chem. 2009 Sep 15;17(18):6583-9. PubMed PMID: 19683932.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidant activity of 5,10-dihydroindeno[1,2-b]indoles containing substituents on dihydroindeno part. AU - Talaz,Oktay, AU - Gülçin,Ilhami, AU - Göksu,Süleyman, AU - Saracoglu,Nurullah, Y1 - 2009/08/05/ PY - 2009/06/03/received PY - 2009/07/26/revised PY - 2009/07/31/accepted PY - 2009/8/18/entrez PY - 2009/8/18/pubmed PY - 2009/12/18/medline SP - 6583 EP - 9 JF - Bioorganic & medicinal chemistry JO - Bioorg. Med. Chem. VL - 17 IS - 18 N2 - An efficient synthesis of 5,10-dihydroindeno[1,2-b]indoles (3a-t) containing substituents such as methoxy, hydroxyl, and halogen (F, Cl, and Br) on indeno part was described. Antioxidant and radical scavenging activities of synthesized compounds (3a-t) were determined by various in vitro assays such as 1,1-diphenyl-2-picryl-hydrazyl free radicals (DPPH(*)), 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid radicals (ABTS(*+)), N,N-dimethyl-p-phenylenediamine dihydrochloride radicals (DMPD(*+)), and superoxide anion radicals (O(2)(*-)) scavenging, reducing ability determination by the Fe(3+)-Fe(2+) and Cu(2+)-Cu(+) (CUPRAC method) transformation methods, H(2)O(2) scavenging, and ferrous ion (Fe(2+)) chelating activities. Moreover, these activities were compared to synthetic and standard antioxidants such as butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), alpha-tocopherol, and trolox. The results showed that the synthesized compounds (3a-t) had effective antioxidant power. SN - 1464-3391 UR - https://www.unboundmedicine.com/medline/citation/19683932/Antioxidant_activity_of_510_dihydroindeno[12_b]indoles_containing_substituents_on_dihydroindeno_part_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0968-0896(09)00750-0 DB - PRIME DP - Unbound Medicine ER -