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The effect of prior sphincterotomy on the secretin-stimulated magnetic resonance cholangiopancreatography (s-MRCP).
Acad Radiol. 2009 Nov; 16(11):1381-5.AR

Abstract

RATIONALE AND OBJECTIVES

A lack of pancreatic duct compliance and decreased duodenal filling on secretin-stimulated magnetic resonance cholangiopancreatography (s-MRCP) has been noted in patients with chronic pancreatitis. Whether endoscopic sphincterotomy can affect pancreatic duct compliance and duodenal filling on diagnostic s-MRCP is unknown.

MATERIALS AND METHODS

A retrospective review of patients referred to the authors' clinic from December 2006 to December 2007 was performed. Those patients with no evidence of chronic pancreatitis who underwent s-MRCP were studied. Findings on s-MRCP were analyzed, specifically noting change in pancreatic duct diameter size from baseline to maximum dilation and duodenal filling after secretin administration (0.2 microg/kg intravenous dose of human secretin).

RESULTS

Of the 34 patients studied, 12 underwent endoscopic sphincterotomy, and 22 had intact sphincters of Oddi. In the sphincterotomy group, there was a mean change of 0.2 cm (range, 0.0-0.4 cm), while in the nonsphincterotomy group, the mean change was 0.9 cm (range, 0.3-2.0 cm) after secretin administration. The difference was significant (P < .005).

CONCLUSION

Endoscopic sphincterotomy significantly decreases pancreatic duct dilation in response to secretin on s-MRCP. However, further studies are required to determine the effect sphincterotomy has on the amount of duodenal filling and the rate at which duodenal filling occurs.

Authors+Show Affiliations

Division of Gastroenterology and Hepatology, St Louis University School of Medicine, 3635 Vista Avenue, St Louis, MO 63110, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Evaluation Study
Journal Article

Language

eng

PubMed ID

19683944

Citation

Chopra, Ashish, et al. "The Effect of Prior Sphincterotomy On the Secretin-stimulated Magnetic Resonance Cholangiopancreatography (s-MRCP)." Academic Radiology, vol. 16, no. 11, 2009, pp. 1381-5.
Chopra A, Alkaade S, Balci NC, et al. The effect of prior sphincterotomy on the secretin-stimulated magnetic resonance cholangiopancreatography (s-MRCP). Acad Radiol. 2009;16(11):1381-5.
Chopra, A., Alkaade, S., Balci, N. C., & Burton, F. (2009). The effect of prior sphincterotomy on the secretin-stimulated magnetic resonance cholangiopancreatography (s-MRCP). Academic Radiology, 16(11), 1381-5. https://doi.org/10.1016/j.acra.2009.06.007
Chopra A, et al. The Effect of Prior Sphincterotomy On the Secretin-stimulated Magnetic Resonance Cholangiopancreatography (s-MRCP). Acad Radiol. 2009;16(11):1381-5. PubMed PMID: 19683944.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of prior sphincterotomy on the secretin-stimulated magnetic resonance cholangiopancreatography (s-MRCP). AU - Chopra,Ashish, AU - Alkaade,Samer, AU - Balci,N Cem, AU - Burton,Frank, Y1 - 2009/08/15/ PY - 2009/05/24/received PY - 2009/06/11/revised PY - 2009/06/12/accepted PY - 2009/8/18/entrez PY - 2009/8/18/pubmed PY - 2010/1/7/medline SP - 1381 EP - 5 JF - Academic radiology JO - Acad Radiol VL - 16 IS - 11 N2 - RATIONALE AND OBJECTIVES: A lack of pancreatic duct compliance and decreased duodenal filling on secretin-stimulated magnetic resonance cholangiopancreatography (s-MRCP) has been noted in patients with chronic pancreatitis. Whether endoscopic sphincterotomy can affect pancreatic duct compliance and duodenal filling on diagnostic s-MRCP is unknown. MATERIALS AND METHODS: A retrospective review of patients referred to the authors' clinic from December 2006 to December 2007 was performed. Those patients with no evidence of chronic pancreatitis who underwent s-MRCP were studied. Findings on s-MRCP were analyzed, specifically noting change in pancreatic duct diameter size from baseline to maximum dilation and duodenal filling after secretin administration (0.2 microg/kg intravenous dose of human secretin). RESULTS: Of the 34 patients studied, 12 underwent endoscopic sphincterotomy, and 22 had intact sphincters of Oddi. In the sphincterotomy group, there was a mean change of 0.2 cm (range, 0.0-0.4 cm), while in the nonsphincterotomy group, the mean change was 0.9 cm (range, 0.3-2.0 cm) after secretin administration. The difference was significant (P < .005). CONCLUSION: Endoscopic sphincterotomy significantly decreases pancreatic duct dilation in response to secretin on s-MRCP. However, further studies are required to determine the effect sphincterotomy has on the amount of duodenal filling and the rate at which duodenal filling occurs. SN - 1878-4046 UR - https://www.unboundmedicine.com/medline/citation/19683944/The_effect_of_prior_sphincterotomy_on_the_secretin_stimulated_magnetic_resonance_cholangiopancreatography__s_MRCP__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1076-6332(09)00360-2 DB - PRIME DP - Unbound Medicine ER -