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Fatigue and its correlates in chronic hemodialysis patients.
Blood Purif. 2009; 28(3):245-52.BP

Abstract

BACKGROUND

The present study aimed at evaluating the possible correlation between fatigue and demographic, clinical and laboratory variables in chronic HD patients.

METHODS

Sixty-two chronic HD patients were assessed for the presence of fatigue through the SF-36 Vitality subscale and were administered the Beck Depression Inventory (BDI), the Hamilton Anxiety Rating Scale (HARS), and the Mini-Mental State Examination. In all, the number/severity of comorbidities was assessed through the Charlson Comorbidity Index and laboratory parameters were measured.

RESULTS

Correlations among the SF-36 Vitality subscale and age, dialytic age, BDI, HARS and the Charlson Comorbidity Index were statistically significant. Correlations between the SF-36 vitality score and the serum creatinine, albumin and IL-6 levels were also significant. Twenty-six and 36 patients constituted the fatigued and nonfatigued groups, respectively. The age and the scores of the Charlson Comorbidity Index, BDI and HARS of fatigued patients were significantly higher than those of nonfatigued subjects. Serum IL-6 levels were significantly higher in the fatigued than in the nonfatigued group, whereas serum albumin and creatinine levels were significantly lower.

CONCLUSIONS

We found that depression, anxiety, number and severity of comorbidities and IL-6 levels are significantly correlated with fatigue in end-stage renal disease patients receiving chronic hemodialysis.

Authors+Show Affiliations

Servizio Emodialisi, Istituto di Clinica Chirurgica, Università Cattolica del Sacro Cuore, Roma, Italia. maubosso@tin.itNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19684391

Citation

Bossola, Maurizio, et al. "Fatigue and Its Correlates in Chronic Hemodialysis Patients." Blood Purification, vol. 28, no. 3, 2009, pp. 245-52.
Bossola M, Luciani G, Tazza L. Fatigue and its correlates in chronic hemodialysis patients. Blood Purif. 2009;28(3):245-52.
Bossola, M., Luciani, G., & Tazza, L. (2009). Fatigue and its correlates in chronic hemodialysis patients. Blood Purification, 28(3), 245-52. https://doi.org/10.1159/000231985
Bossola M, Luciani G, Tazza L. Fatigue and Its Correlates in Chronic Hemodialysis Patients. Blood Purif. 2009;28(3):245-52. PubMed PMID: 19684391.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fatigue and its correlates in chronic hemodialysis patients. AU - Bossola,Maurizio, AU - Luciani,Giovanna, AU - Tazza,Luigi, Y1 - 2009/08/14/ PY - 2009/03/19/received PY - 2009/06/02/accepted PY - 2009/8/18/entrez PY - 2009/8/18/pubmed PY - 2010/1/8/medline SP - 245 EP - 52 JF - Blood purification JO - Blood Purif VL - 28 IS - 3 N2 - BACKGROUND: The present study aimed at evaluating the possible correlation between fatigue and demographic, clinical and laboratory variables in chronic HD patients. METHODS: Sixty-two chronic HD patients were assessed for the presence of fatigue through the SF-36 Vitality subscale and were administered the Beck Depression Inventory (BDI), the Hamilton Anxiety Rating Scale (HARS), and the Mini-Mental State Examination. In all, the number/severity of comorbidities was assessed through the Charlson Comorbidity Index and laboratory parameters were measured. RESULTS: Correlations among the SF-36 Vitality subscale and age, dialytic age, BDI, HARS and the Charlson Comorbidity Index were statistically significant. Correlations between the SF-36 vitality score and the serum creatinine, albumin and IL-6 levels were also significant. Twenty-six and 36 patients constituted the fatigued and nonfatigued groups, respectively. The age and the scores of the Charlson Comorbidity Index, BDI and HARS of fatigued patients were significantly higher than those of nonfatigued subjects. Serum IL-6 levels were significantly higher in the fatigued than in the nonfatigued group, whereas serum albumin and creatinine levels were significantly lower. CONCLUSIONS: We found that depression, anxiety, number and severity of comorbidities and IL-6 levels are significantly correlated with fatigue in end-stage renal disease patients receiving chronic hemodialysis. SN - 1421-9735 UR - https://www.unboundmedicine.com/medline/citation/19684391/Fatigue_and_its_correlates_in_chronic_hemodialysis_patients_ L2 - https://www.karger.com?DOI=10.1159/000231985 DB - PRIME DP - Unbound Medicine ER -