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Poly(ethylene glycol)-stabilized silver nanoparticles for bioanalytical applications of SERS spectroscopy.
Analyst. 2009 Sep; 134(9):1868-72.A

Abstract

The present work depicts the efficient one-step synthesis and detailed evaluation of stable aqueous colloids of silver nanoparticles (NPs) coated with poly(ethylene glycol) (PEG) covalently attached to their surface. Due to steric repulsion between polymer-modified surfaces, the stability of the nanoparticle suspension was preserved even at high ionic strength (0.1 M NaCl). At the same time, the PEG coating remains sufficiently permeable to allow surface-enhanced Raman scattering (SERS) from micromolar concentrations of small molecules such as the anticancer drug mitoxantrone (MTX). The enhancement efficiency of the hot spot-free Ag-PEG was compared to that of citrate-stabilized Ag colloids used after pre-aggregation. The potential of the polymer-stabilized colloids developed in this study is discussed in terms of bioanalytical applications of SERS spectroscopy.

Authors+Show Affiliations

EA 4244, Physicochimie des matériaux et des biomolécules, groupe Nanovecteurs magnétiques pour la chimiothérapie, Université F. Rabelais, Faculté de Pharmacie, 31 avenue Monge, F-37200 Tours, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19684912

Citation

Shkilnyy, Andriy, et al. "Poly(ethylene Glycol)-stabilized Silver Nanoparticles for Bioanalytical Applications of SERS Spectroscopy." The Analyst, vol. 134, no. 9, 2009, pp. 1868-72.
Shkilnyy A, Soucé M, Dubois P, et al. Poly(ethylene glycol)-stabilized silver nanoparticles for bioanalytical applications of SERS spectroscopy. Analyst. 2009;134(9):1868-72.
Shkilnyy, A., Soucé, M., Dubois, P., Warmont, F., Saboungi, M. L., & Chourpa, I. (2009). Poly(ethylene glycol)-stabilized silver nanoparticles for bioanalytical applications of SERS spectroscopy. The Analyst, 134(9), 1868-72. https://doi.org/10.1039/b905694g
Shkilnyy A, et al. Poly(ethylene Glycol)-stabilized Silver Nanoparticles for Bioanalytical Applications of SERS Spectroscopy. Analyst. 2009;134(9):1868-72. PubMed PMID: 19684912.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Poly(ethylene glycol)-stabilized silver nanoparticles for bioanalytical applications of SERS spectroscopy. AU - Shkilnyy,Andriy, AU - Soucé,Martin, AU - Dubois,Pierre, AU - Warmont,Fabienne, AU - Saboungi,Marie-Louise, AU - Chourpa,Igor, Y1 - 2009/07/06/ PY - 2009/8/18/entrez PY - 2009/8/18/pubmed PY - 2010/3/5/medline SP - 1868 EP - 72 JF - The Analyst JO - Analyst VL - 134 IS - 9 N2 - The present work depicts the efficient one-step synthesis and detailed evaluation of stable aqueous colloids of silver nanoparticles (NPs) coated with poly(ethylene glycol) (PEG) covalently attached to their surface. Due to steric repulsion between polymer-modified surfaces, the stability of the nanoparticle suspension was preserved even at high ionic strength (0.1 M NaCl). At the same time, the PEG coating remains sufficiently permeable to allow surface-enhanced Raman scattering (SERS) from micromolar concentrations of small molecules such as the anticancer drug mitoxantrone (MTX). The enhancement efficiency of the hot spot-free Ag-PEG was compared to that of citrate-stabilized Ag colloids used after pre-aggregation. The potential of the polymer-stabilized colloids developed in this study is discussed in terms of bioanalytical applications of SERS spectroscopy. SN - 1364-5528 UR - https://www.unboundmedicine.com/medline/citation/19684912/Poly_ethylene_glycol__stabilized_silver_nanoparticles_for_bioanalytical_applications_of_SERS_spectroscopy_ L2 - https://doi.org/10.1039/b905694g DB - PRIME DP - Unbound Medicine ER -