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Effect of fish oil (n-3 polyunsaturated fatty acids) on plasma lipids, lipoproteins and inflammatory markers in HIV-infected patients treated with antiretroviral therapy: a randomized, double-blind, placebo-controlled study.

Abstract

Patients on antiretroviral therapy are reported to have an increased risk of cardiovascular disease. We aimed to investigate the effect of n-3 polyunsaturated fatty acids (n-3 PUFAs) on plasma lipids, lipoproteins and inflammatory markers in HIV-infected patients treated with antiretroviral therapy. We randomized 51 patients in a placebo-controlled, double-blind trial to receive either 2 capsules of Omacor twice daily or 2 capsules of placebo. Compliance was measured by determining levels of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in neutrophils. Plasma triglycerides were reduced in the n-3 PUFA group by 0.14 mmol/l after 12 weeks of treatment (n=26), while plasma triglycerides increased by 0.36 mmol/l in the control group (n=25). The difference between groups was significant, p=0.03. No significant effect of treatment was found for total cholesterol, high-density lipoprotein (HDL) or low-density lipoprotein (LDL) cholesterol or apolipoproteins. There was a significant increase in leukotriene B5 (LTB5) and LTB5/LTB4 ratio in the n-3 PUFA group compared to the control group. Baseline values for intercellular adhesion molecule-1 (ICAM), vascular cell adhesion molecule-1 (VCAM) and highly sensitive C-reactive protein (hsCRP) were comparable at baseline, and the intervention did not change these parameters significantly. The present study showed that treatment with n-3 PUFA slightly decreased plasma triglycerides and induced anti-inflammatory effects by increasing formation of anti-inflammatory LTB5.

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  • Authors+Show Affiliations

    ,

    Department of Infectious Diseases, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark.

    , , , , , ,

    Source

    MeSH

    Adult
    Anti-Retroviral Agents
    Cholesterol
    Docosahexaenoic Acids
    Double-Blind Method
    Drug Combinations
    Eicosapentaenoic Acid
    Fatty Acids, Omega-3
    Female
    HIV Infections
    Humans
    Inflammation Mediators
    Lipid Metabolism
    Lipids
    Lipoproteins
    Male
    Middle Aged
    Neutrophils
    Placebos
    Triglycerides

    Pub Type(s)

    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    19685375

    Citation

    Thusgaard, Marianne, et al. "Effect of Fish Oil (n-3 Polyunsaturated Fatty Acids) On Plasma Lipids, Lipoproteins and Inflammatory Markers in HIV-infected Patients Treated With Antiretroviral Therapy: a Randomized, Double-blind, Placebo-controlled Study." Scandinavian Journal of Infectious Diseases, vol. 41, no. 10, 2009, pp. 760-6.
    Thusgaard M, Christensen JH, Mørn B, et al. Effect of fish oil (n-3 polyunsaturated fatty acids) on plasma lipids, lipoproteins and inflammatory markers in HIV-infected patients treated with antiretroviral therapy: a randomized, double-blind, placebo-controlled study. Scand J Infect Dis. 2009;41(10):760-6.
    Thusgaard, M., Christensen, J. H., Mørn, B., Andersen, T. S., Vige, R., Arildsen, H., ... Nielsen, H. (2009). Effect of fish oil (n-3 polyunsaturated fatty acids) on plasma lipids, lipoproteins and inflammatory markers in HIV-infected patients treated with antiretroviral therapy: a randomized, double-blind, placebo-controlled study. Scandinavian Journal of Infectious Diseases, 41(10), pp. 760-6. doi:10.1080/00365540903168056.
    Thusgaard M, et al. Effect of Fish Oil (n-3 Polyunsaturated Fatty Acids) On Plasma Lipids, Lipoproteins and Inflammatory Markers in HIV-infected Patients Treated With Antiretroviral Therapy: a Randomized, Double-blind, Placebo-controlled Study. Scand J Infect Dis. 2009;41(10):760-6. PubMed PMID: 19685375.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effect of fish oil (n-3 polyunsaturated fatty acids) on plasma lipids, lipoproteins and inflammatory markers in HIV-infected patients treated with antiretroviral therapy: a randomized, double-blind, placebo-controlled study. AU - Thusgaard,Marianne, AU - Christensen,Jesper H, AU - Mørn,Birgitte, AU - Andersen,Tina S, AU - Vige,Runar, AU - Arildsen,Hanne, AU - Schmidt,Erik B, AU - Nielsen,Henrik, PY - 2009/8/18/entrez PY - 2009/8/18/pubmed PY - 2010/3/24/medline SP - 760 EP - 6 JF - Scandinavian journal of infectious diseases JO - Scand. J. Infect. Dis. VL - 41 IS - 10 N2 - Patients on antiretroviral therapy are reported to have an increased risk of cardiovascular disease. We aimed to investigate the effect of n-3 polyunsaturated fatty acids (n-3 PUFAs) on plasma lipids, lipoproteins and inflammatory markers in HIV-infected patients treated with antiretroviral therapy. We randomized 51 patients in a placebo-controlled, double-blind trial to receive either 2 capsules of Omacor twice daily or 2 capsules of placebo. Compliance was measured by determining levels of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in neutrophils. Plasma triglycerides were reduced in the n-3 PUFA group by 0.14 mmol/l after 12 weeks of treatment (n=26), while plasma triglycerides increased by 0.36 mmol/l in the control group (n=25). The difference between groups was significant, p=0.03. No significant effect of treatment was found for total cholesterol, high-density lipoprotein (HDL) or low-density lipoprotein (LDL) cholesterol or apolipoproteins. There was a significant increase in leukotriene B5 (LTB5) and LTB5/LTB4 ratio in the n-3 PUFA group compared to the control group. Baseline values for intercellular adhesion molecule-1 (ICAM), vascular cell adhesion molecule-1 (VCAM) and highly sensitive C-reactive protein (hsCRP) were comparable at baseline, and the intervention did not change these parameters significantly. The present study showed that treatment with n-3 PUFA slightly decreased plasma triglycerides and induced anti-inflammatory effects by increasing formation of anti-inflammatory LTB5. SN - 1651-1980 UR - https://www.unboundmedicine.com/medline/citation/19685375/Effect_of_fish_oil__n_3_polyunsaturated_fatty_acids__on_plasma_lipids_lipoproteins_and_inflammatory_markers_in_HIV_infected_patients_treated_with_antiretroviral_therapy:_a_randomized_double_blind_placebo_controlled_study_ L2 - http://www.tandfonline.com/doi/full/10.1080/00365540903168056 DB - PRIME DP - Unbound Medicine ER -