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Effect of fish oil (n-3 polyunsaturated fatty acids) on plasma lipids, lipoproteins and inflammatory markers in HIV-infected patients treated with antiretroviral therapy: a randomized, double-blind, placebo-controlled study.
Scand J Infect Dis 2009; 41(10):760-6SJ

Abstract

Patients on antiretroviral therapy are reported to have an increased risk of cardiovascular disease. We aimed to investigate the effect of n-3 polyunsaturated fatty acids (n-3 PUFAs) on plasma lipids, lipoproteins and inflammatory markers in HIV-infected patients treated with antiretroviral therapy. We randomized 51 patients in a placebo-controlled, double-blind trial to receive either 2 capsules of Omacor twice daily or 2 capsules of placebo. Compliance was measured by determining levels of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in neutrophils. Plasma triglycerides were reduced in the n-3 PUFA group by 0.14 mmol/l after 12 weeks of treatment (n=26), while plasma triglycerides increased by 0.36 mmol/l in the control group (n=25). The difference between groups was significant, p=0.03. No significant effect of treatment was found for total cholesterol, high-density lipoprotein (HDL) or low-density lipoprotein (LDL) cholesterol or apolipoproteins. There was a significant increase in leukotriene B5 (LTB5) and LTB5/LTB4 ratio in the n-3 PUFA group compared to the control group. Baseline values for intercellular adhesion molecule-1 (ICAM), vascular cell adhesion molecule-1 (VCAM) and highly sensitive C-reactive protein (hsCRP) were comparable at baseline, and the intervention did not change these parameters significantly. The present study showed that treatment with n-3 PUFA slightly decreased plasma triglycerides and induced anti-inflammatory effects by increasing formation of anti-inflammatory LTB5.

Authors+Show Affiliations

Department of Infectious Diseases, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19685375

Citation

Thusgaard, Marianne, et al. "Effect of Fish Oil (n-3 Polyunsaturated Fatty Acids) On Plasma Lipids, Lipoproteins and Inflammatory Markers in HIV-infected Patients Treated With Antiretroviral Therapy: a Randomized, Double-blind, Placebo-controlled Study." Scandinavian Journal of Infectious Diseases, vol. 41, no. 10, 2009, pp. 760-6.
Thusgaard M, Christensen JH, Mørn B, et al. Effect of fish oil (n-3 polyunsaturated fatty acids) on plasma lipids, lipoproteins and inflammatory markers in HIV-infected patients treated with antiretroviral therapy: a randomized, double-blind, placebo-controlled study. Scand J Infect Dis. 2009;41(10):760-6.
Thusgaard, M., Christensen, J. H., Mørn, B., Andersen, T. S., Vige, R., Arildsen, H., ... Nielsen, H. (2009). Effect of fish oil (n-3 polyunsaturated fatty acids) on plasma lipids, lipoproteins and inflammatory markers in HIV-infected patients treated with antiretroviral therapy: a randomized, double-blind, placebo-controlled study. Scandinavian Journal of Infectious Diseases, 41(10), pp. 760-6. doi:10.1080/00365540903168056.
Thusgaard M, et al. Effect of Fish Oil (n-3 Polyunsaturated Fatty Acids) On Plasma Lipids, Lipoproteins and Inflammatory Markers in HIV-infected Patients Treated With Antiretroviral Therapy: a Randomized, Double-blind, Placebo-controlled Study. Scand J Infect Dis. 2009;41(10):760-6. PubMed PMID: 19685375.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of fish oil (n-3 polyunsaturated fatty acids) on plasma lipids, lipoproteins and inflammatory markers in HIV-infected patients treated with antiretroviral therapy: a randomized, double-blind, placebo-controlled study. AU - Thusgaard,Marianne, AU - Christensen,Jesper H, AU - Mørn,Birgitte, AU - Andersen,Tina S, AU - Vige,Runar, AU - Arildsen,Hanne, AU - Schmidt,Erik B, AU - Nielsen,Henrik, PY - 2009/8/18/entrez PY - 2009/8/18/pubmed PY - 2010/3/24/medline SP - 760 EP - 6 JF - Scandinavian journal of infectious diseases JO - Scand. J. Infect. Dis. VL - 41 IS - 10 N2 - Patients on antiretroviral therapy are reported to have an increased risk of cardiovascular disease. We aimed to investigate the effect of n-3 polyunsaturated fatty acids (n-3 PUFAs) on plasma lipids, lipoproteins and inflammatory markers in HIV-infected patients treated with antiretroviral therapy. We randomized 51 patients in a placebo-controlled, double-blind trial to receive either 2 capsules of Omacor twice daily or 2 capsules of placebo. Compliance was measured by determining levels of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in neutrophils. Plasma triglycerides were reduced in the n-3 PUFA group by 0.14 mmol/l after 12 weeks of treatment (n=26), while plasma triglycerides increased by 0.36 mmol/l in the control group (n=25). The difference between groups was significant, p=0.03. No significant effect of treatment was found for total cholesterol, high-density lipoprotein (HDL) or low-density lipoprotein (LDL) cholesterol or apolipoproteins. There was a significant increase in leukotriene B5 (LTB5) and LTB5/LTB4 ratio in the n-3 PUFA group compared to the control group. Baseline values for intercellular adhesion molecule-1 (ICAM), vascular cell adhesion molecule-1 (VCAM) and highly sensitive C-reactive protein (hsCRP) were comparable at baseline, and the intervention did not change these parameters significantly. The present study showed that treatment with n-3 PUFA slightly decreased plasma triglycerides and induced anti-inflammatory effects by increasing formation of anti-inflammatory LTB5. SN - 1651-1980 UR - https://www.unboundmedicine.com/medline/citation/19685375/Effect_of_fish_oil__n_3_polyunsaturated_fatty_acids__on_plasma_lipids_lipoproteins_and_inflammatory_markers_in_HIV_infected_patients_treated_with_antiretroviral_therapy:_a_randomized_double_blind_placebo_controlled_study_ L2 - http://www.tandfonline.com/doi/full/10.1080/00365540903168056 DB - PRIME DP - Unbound Medicine ER -