Tags

Type your tag names separated by a space and hit enter

Antioxidant intake from fruits, vegetables and other sources and risk of non-Hodgkin's lymphoma: the Iowa Women's Health Study.

Abstract

Antioxidant nutrients found in fruits, vegetables and other foods are thought to inhibit carcinogenesis and to influence immune status. We evaluated the association of these factors with risk of non-Hodgkin's lymphoma (NHL) overall and for diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma specifically in a prospective cohort of 35,159 Iowa women aged 55-69 years when enrolled at baseline in 1986. Diet was ascertained using a validated semiquantitative food frequency questionnaire. Through 2005, 415 cases of NHL (including 184 DLBCL and 90 follicular) were identified. Relative risks (RRs) and 95% confidence intervals (CIs) were estimated using Cox regression, adjusting for age and total energy. The strongest associations of antioxidants with risk of NHL (RR for highest versus lowest quartile; p for trend) were observed for dietary vitamin C (RR = 0.78; p = 0.044), alpha-carotene (RR = 0.71; p = 0.015), proanthocyanidins (RR = 0.70; p = 0.0024) and dietary manganese (RR = 0.62; p = 0.010). There were no associations with multivitamin use or supplemental intake of vitamins C, E, selenium, zinc, copper or manganese. From a food perspective, greater intake of total fruits and vegetables (RR = 0.69; p = 0.011), yellow/orange (RR = 0.72; p = 0.015) and cruciferous (RR = 0.82; p = 0.017) vegetables, broccoli (RR = 0.72; p = 0.018) and apple juice/cider (RR = 0.65; p = 0.026) were associated with lower NHL risk; there were no strong associations for other antioxidant-rich foods, including whole grains, chocolate, tea or nuts. Overall, these associations were mainly observed for follicular lymphoma and were weaker or not apparent for DLBCL. In conclusion, these results support a role for vegetables, and perhaps fruits and associated antioxidants from food sources, as protective factors against the development of NHL and follicular lymphoma in particular.

Links

  • PMC Free PDF
  • PMC Free Full Text
  • FREE Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Medicine, College of Medicine Mayo Clinic, Rochester, MN, USA.

    , , , , ,

    Source

    International journal of cancer 126:4 2010 Feb 15 pg 992-1003

    MeSH

    Aged
    Alcohol Drinking
    Antioxidants
    Diet
    Educational Status
    Female
    Fruit
    Humans
    Iowa
    Lymphoma, Non-Hodgkin
    Meat
    Middle Aged
    Regression Analysis
    Risk
    Risk Factors
    Smoking
    Surveys and Questionnaires
    Vegetables
    Vitamins

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    19685491

    Citation

    Thompson, Carrie A., et al. "Antioxidant Intake From Fruits, Vegetables and Other Sources and Risk of non-Hodgkin's Lymphoma: the Iowa Women's Health Study." International Journal of Cancer, vol. 126, no. 4, 2010, pp. 992-1003.
    Thompson CA, Habermann TM, Wang AH, et al. Antioxidant intake from fruits, vegetables and other sources and risk of non-Hodgkin's lymphoma: the Iowa Women's Health Study. Int J Cancer. 2010;126(4):992-1003.
    Thompson, C. A., Habermann, T. M., Wang, A. H., Vierkant, R. A., Folsom, A. R., Ross, J. A., & Cerhan, J. R. (2010). Antioxidant intake from fruits, vegetables and other sources and risk of non-Hodgkin's lymphoma: the Iowa Women's Health Study. International Journal of Cancer, 126(4), pp. 992-1003. doi:10.1002/ijc.24830.
    Thompson CA, et al. Antioxidant Intake From Fruits, Vegetables and Other Sources and Risk of non-Hodgkin's Lymphoma: the Iowa Women's Health Study. Int J Cancer. 2010 Feb 15;126(4):992-1003. PubMed PMID: 19685491.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Antioxidant intake from fruits, vegetables and other sources and risk of non-Hodgkin's lymphoma: the Iowa Women's Health Study. AU - Thompson,Carrie A, AU - Habermann,Thomas M, AU - Wang,Alice H, AU - Vierkant,Robert A, AU - Folsom,Aaron R, AU - Ross,Julie A, AU - Cerhan,James R, PY - 2009/8/18/entrez PY - 2009/8/18/pubmed PY - 2010/2/2/medline SP - 992 EP - 1003 JF - International journal of cancer JO - Int. J. Cancer VL - 126 IS - 4 N2 - Antioxidant nutrients found in fruits, vegetables and other foods are thought to inhibit carcinogenesis and to influence immune status. We evaluated the association of these factors with risk of non-Hodgkin's lymphoma (NHL) overall and for diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma specifically in a prospective cohort of 35,159 Iowa women aged 55-69 years when enrolled at baseline in 1986. Diet was ascertained using a validated semiquantitative food frequency questionnaire. Through 2005, 415 cases of NHL (including 184 DLBCL and 90 follicular) were identified. Relative risks (RRs) and 95% confidence intervals (CIs) were estimated using Cox regression, adjusting for age and total energy. The strongest associations of antioxidants with risk of NHL (RR for highest versus lowest quartile; p for trend) were observed for dietary vitamin C (RR = 0.78; p = 0.044), alpha-carotene (RR = 0.71; p = 0.015), proanthocyanidins (RR = 0.70; p = 0.0024) and dietary manganese (RR = 0.62; p = 0.010). There were no associations with multivitamin use or supplemental intake of vitamins C, E, selenium, zinc, copper or manganese. From a food perspective, greater intake of total fruits and vegetables (RR = 0.69; p = 0.011), yellow/orange (RR = 0.72; p = 0.015) and cruciferous (RR = 0.82; p = 0.017) vegetables, broccoli (RR = 0.72; p = 0.018) and apple juice/cider (RR = 0.65; p = 0.026) were associated with lower NHL risk; there were no strong associations for other antioxidant-rich foods, including whole grains, chocolate, tea or nuts. Overall, these associations were mainly observed for follicular lymphoma and were weaker or not apparent for DLBCL. In conclusion, these results support a role for vegetables, and perhaps fruits and associated antioxidants from food sources, as protective factors against the development of NHL and follicular lymphoma in particular. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/19685491/Antioxidant_intake_from_fruits_vegetables_and_other_sources_and_risk_of_non_Hodgkin's_lymphoma:_the_Iowa_Women's_Health_Study_ L2 - https://doi.org/10.1002/ijc.24830 DB - PRIME DP - Unbound Medicine ER -