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Fasting hyperinsulinemia associates with increased sub-clinical inflammation in first-degree relatives normal glucose tolerant women independently of the metabolic syndrome.
Diabetes Metab Res Rev. 2009 Oct; 25(7):639-46.DM

Abstract

BACKGROUND

To evaluate the influence of gender on the relationship between inflammation and hyperinsulinemia in first-degree relatives of type 2 diabetic patients independently of metabolic syndrome.

METHODS

Study group consisted in 217 first-degree relatives with normal glucose tolerance after an oral glucose tolerance test. A logistic analysis, adjusted for age, sex and all the components of the metabolic syndrome, was used to determine the relationship between interleukin-6 (IL-6) and leptin and tertiles of fasting insulin, and to take into account the influence of gender.

RESULTS

In the whole cohort, IL-6 and leptin were significantly higher and adiponectin significantly lower in the III tertile when corrected for age, body mass index (BMI) and metabolic syndrome components. In women, but not in men, IL-6 and leptin remained significantly higher when corrected for metabolic syndrome. In the whole cohort and in women, univariate correlations between IL-6 concentrations and the parameters under evaluation showed that IL-6 and leptin were positively correlated with age, BMI, waist, systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting glucose, fasting insulin, Delta AUC insulin area, triglyceride (TG), free fatty acids (FFA) and monocyte chemoattractant protein-1 (MCP-1) and inversely correlated with HDL cholesterol (HDL-C) and adiponectin. In women a forward stepwise linear regression analysis in a model including age, BMI, features of metabolic syndrome, fasting insulin, Delta AUC insulin and insulin sensitivity index (ISI) index revealed that only IL-6 and leptin were independently associated with fasting insulin levels.

CONCLUSIONS

In first-degree relatives normal glucose tolerant women, fasting hyperinsulinemia, independently of the presence of metabolic syndrome, is associated with elevated IL-6 and leptin levels, suggesting an increased cardiovascular risk.

Authors+Show Affiliations

Cardio-Metabolic and Clinical Trials Unit and Cardiodiabetes & Core-Lab, Metabolic and Cardiovascular Science Division and Internal Medicine Department, San Raffaele Scientific Institute, Milan, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19685554

Citation

Setola, Emanuela, et al. "Fasting Hyperinsulinemia Associates With Increased Sub-clinical Inflammation in First-degree Relatives Normal Glucose Tolerant Women Independently of the Metabolic Syndrome." Diabetes/metabolism Research and Reviews, vol. 25, no. 7, 2009, pp. 639-46.
Setola E, Monti LD, Lucotti P, et al. Fasting hyperinsulinemia associates with increased sub-clinical inflammation in first-degree relatives normal glucose tolerant women independently of the metabolic syndrome. Diabetes Metab Res Rev. 2009;25(7):639-46.
Setola, E., Monti, L. D., Lucotti, P., Galluccio, E., Oldani, M., Bosi, E., & Piatti, P. (2009). Fasting hyperinsulinemia associates with increased sub-clinical inflammation in first-degree relatives normal glucose tolerant women independently of the metabolic syndrome. Diabetes/metabolism Research and Reviews, 25(7), 639-46. https://doi.org/10.1002/dmrr.1003
Setola E, et al. Fasting Hyperinsulinemia Associates With Increased Sub-clinical Inflammation in First-degree Relatives Normal Glucose Tolerant Women Independently of the Metabolic Syndrome. Diabetes Metab Res Rev. 2009;25(7):639-46. PubMed PMID: 19685554.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fasting hyperinsulinemia associates with increased sub-clinical inflammation in first-degree relatives normal glucose tolerant women independently of the metabolic syndrome. AU - Setola,Emanuela, AU - Monti,Lucilla D, AU - Lucotti,Pietro, AU - Galluccio,Elena, AU - Oldani,Matteo, AU - Bosi,Emanuele, AU - Piatti,PierMarco, PY - 2009/8/18/entrez PY - 2009/8/18/pubmed PY - 2010/1/27/medline SP - 639 EP - 46 JF - Diabetes/metabolism research and reviews JO - Diabetes Metab Res Rev VL - 25 IS - 7 N2 - BACKGROUND: To evaluate the influence of gender on the relationship between inflammation and hyperinsulinemia in first-degree relatives of type 2 diabetic patients independently of metabolic syndrome. METHODS: Study group consisted in 217 first-degree relatives with normal glucose tolerance after an oral glucose tolerance test. A logistic analysis, adjusted for age, sex and all the components of the metabolic syndrome, was used to determine the relationship between interleukin-6 (IL-6) and leptin and tertiles of fasting insulin, and to take into account the influence of gender. RESULTS: In the whole cohort, IL-6 and leptin were significantly higher and adiponectin significantly lower in the III tertile when corrected for age, body mass index (BMI) and metabolic syndrome components. In women, but not in men, IL-6 and leptin remained significantly higher when corrected for metabolic syndrome. In the whole cohort and in women, univariate correlations between IL-6 concentrations and the parameters under evaluation showed that IL-6 and leptin were positively correlated with age, BMI, waist, systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting glucose, fasting insulin, Delta AUC insulin area, triglyceride (TG), free fatty acids (FFA) and monocyte chemoattractant protein-1 (MCP-1) and inversely correlated with HDL cholesterol (HDL-C) and adiponectin. In women a forward stepwise linear regression analysis in a model including age, BMI, features of metabolic syndrome, fasting insulin, Delta AUC insulin and insulin sensitivity index (ISI) index revealed that only IL-6 and leptin were independently associated with fasting insulin levels. CONCLUSIONS: In first-degree relatives normal glucose tolerant women, fasting hyperinsulinemia, independently of the presence of metabolic syndrome, is associated with elevated IL-6 and leptin levels, suggesting an increased cardiovascular risk. SN - 1520-7560 UR - https://www.unboundmedicine.com/medline/citation/19685554/Fasting_hyperinsulinemia_associates_with_increased_sub_clinical_inflammation_in_first_degree_relatives_normal_glucose_tolerant_women_independently_of_the_metabolic_syndrome_ L2 - https://doi.org/10.1002/dmrr.1003 DB - PRIME DP - Unbound Medicine ER -