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Gastrinomas in the duodenums of patients with multiple endocrine neoplasia type 1 and the Zollinger-Ellison syndrome.
N Engl J Med. 1990 Mar 15; 322(11):723-7.NEJM

Abstract

In patients with multiple endocrine neoplasia type 1 (MEN-1), gastrinomas are common and thought to occur predominantly in the pancreas. We describe eight patients with MEN-1 and hypergastrinemia (seven with the Zollinger-Ellison syndrome) in whom we searched for neuroendocrine tumors in the pancreas and duodenum. Tumors were found in the proximal duodenum in all eight patients: solitary tumors (diameter, 6 to 20 mm) in three patients and multiple microtumors (diameter, 2 to 6 mm) in the other five. Paraduodenal lymph-node metastases were detected in four patients. Immunocytochemical analysis revealed the presence of gastrin in all the duodenal tumors and in their lymph-node metastases. In contrast, no immunoreactivity for gastrin was present in the endocrine tumors found in the seven pancreatic specimens available for study, except for one tumor with scattered gastrin-positive cells. In four of the six patients whose duodenal gastrinomas were removed, serum gastrin levels returned to normal; in the other two patients gastrin concentrations decreased toward normal. We conclude that in patients with MEN-1 and the Zollinger-Ellison syndrome, gastrinomas occur in the duodenum, but the tumors may be so small that they escape detection.

Authors+Show Affiliations

Department of Pathology, Academic Hospital, Vrije Universiteit Brussel, Belgium.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1968616

Citation

Pipeleers-Marichal, M, et al. "Gastrinomas in the Duodenums of Patients With Multiple Endocrine Neoplasia Type 1 and the Zollinger-Ellison Syndrome." The New England Journal of Medicine, vol. 322, no. 11, 1990, pp. 723-7.
Pipeleers-Marichal M, Somers G, Willems G, et al. Gastrinomas in the duodenums of patients with multiple endocrine neoplasia type 1 and the Zollinger-Ellison syndrome. N Engl J Med. 1990;322(11):723-7.
Pipeleers-Marichal, M., Somers, G., Willems, G., Foulis, A., Imrie, C., Bishop, A. E., Polak, J. M., Häcki, W. H., Stamm, B., & Heitz, P. U. (1990). Gastrinomas in the duodenums of patients with multiple endocrine neoplasia type 1 and the Zollinger-Ellison syndrome. The New England Journal of Medicine, 322(11), 723-7.
Pipeleers-Marichal M, et al. Gastrinomas in the Duodenums of Patients With Multiple Endocrine Neoplasia Type 1 and the Zollinger-Ellison Syndrome. N Engl J Med. 1990 Mar 15;322(11):723-7. PubMed PMID: 1968616.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gastrinomas in the duodenums of patients with multiple endocrine neoplasia type 1 and the Zollinger-Ellison syndrome. A1 - Pipeleers-Marichal,M, AU - Somers,G, AU - Willems,G, AU - Foulis,A, AU - Imrie,C, AU - Bishop,A E, AU - Polak,J M, AU - Häcki,W H, AU - Stamm,B, AU - Heitz,P U, PY - 1990/3/15/pubmed PY - 1990/3/15/medline PY - 1990/3/15/entrez SP - 723 EP - 7 JF - The New England journal of medicine JO - N. Engl. J. Med. VL - 322 IS - 11 N2 - In patients with multiple endocrine neoplasia type 1 (MEN-1), gastrinomas are common and thought to occur predominantly in the pancreas. We describe eight patients with MEN-1 and hypergastrinemia (seven with the Zollinger-Ellison syndrome) in whom we searched for neuroendocrine tumors in the pancreas and duodenum. Tumors were found in the proximal duodenum in all eight patients: solitary tumors (diameter, 6 to 20 mm) in three patients and multiple microtumors (diameter, 2 to 6 mm) in the other five. Paraduodenal lymph-node metastases were detected in four patients. Immunocytochemical analysis revealed the presence of gastrin in all the duodenal tumors and in their lymph-node metastases. In contrast, no immunoreactivity for gastrin was present in the endocrine tumors found in the seven pancreatic specimens available for study, except for one tumor with scattered gastrin-positive cells. In four of the six patients whose duodenal gastrinomas were removed, serum gastrin levels returned to normal; in the other two patients gastrin concentrations decreased toward normal. We conclude that in patients with MEN-1 and the Zollinger-Ellison syndrome, gastrinomas occur in the duodenum, but the tumors may be so small that they escape detection. SN - 0028-4793 UR - https://www.unboundmedicine.com/medline/citation/1968616/Gastrinomas_in_the_duodenums_of_patients_with_multiple_endocrine_neoplasia_type_1_and_the_Zollinger_Ellison_syndrome_ L2 - http://www.nejm.org/doi/full/10.1056/NEJM199003153221103?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -