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Risk is in the air: an intranasal MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) rat model of Parkinson's disease.
Ann N Y Acad Sci. 2009 Jul; 1170:629-36.AN

Abstract

The presence of smell loss and the early pathological involvement of the olfactory pathways in the early stages of some neurodegenerative disorders are in accord with the tenants of the olfactory vector hypothesis. This hypothesis postulates that some such diseases may be caused or catalyzed by agents that enter the brain via the olfactory mucosa. In this study, rats infused intranasally (i.n.) with a low concentration of the proneurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) subsequently suffered olfactory, cognitive, and motor function impairments conceivably analogous to those observed during different stages of the development of Parkinson's disease (PD). Such infusion decreased the expression of the enzyme tyrosine hydroxylase in the olfactory bulb and substantia nigra by means of apoptotic mechanisms, reducing dopamine levels in different brain structures, such as the olfactory bulb, striatum, and prefrontal cortex. These findings reinforce the suggestion that the olfactory system may be a particularly sensitive route for the penetration of xenobiotic agents into the central nervous system and that the i.n. MPTP rat model may provide insight into the underlying mechanisms of PD pathogenesis, potentially leading to the development of new therapeutic strategies for this devastating disease.

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Authors+Show Affiliations

Prediger RD
Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, UFSC, Florianópolis, SC, Brazil. ruidsp@hotmail.com
Rial D
No affiliation info available
Medeiros R
No affiliation info available
Figueiredo CP
No affiliation info available
Doty RL
No affiliation info available
Takahashi RN
No affiliation info available

MeSH

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineAnimalsDisease Models, AnimalDopamineDopamine Plasma Membrane Transport ProteinsInhalation ExposureMPTP PoisoningParkinson DiseaseRats

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19686204

Citation

Prediger, Rui D S., et al. "Risk Is in the Air: an Intranasal MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) Rat Model of Parkinson's Disease." Annals of the New York Academy of Sciences, vol. 1170, 2009, pp. 629-36.
Prediger RD, Rial D, Medeiros R, et al. Risk is in the air: an intranasal MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) rat model of Parkinson's disease. Ann N Y Acad Sci. 2009;1170:629-36.
Prediger, R. D., Rial, D., Medeiros, R., Figueiredo, C. P., Doty, R. L., & Takahashi, R. N. (2009). Risk is in the air: an intranasal MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) rat model of Parkinson's disease. Annals of the New York Academy of Sciences, 1170, 629-36. https://doi.org/10.1111/j.1749-6632.2009.03885.x
Prediger RD, et al. Risk Is in the Air: an Intranasal MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) Rat Model of Parkinson's Disease. Ann N Y Acad Sci. 2009;1170:629-36. PubMed PMID: 19686204.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk is in the air: an intranasal MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) rat model of Parkinson's disease. AU - Prediger,Rui D S, AU - Rial,Daniel, AU - Medeiros,Rodrigo, AU - Figueiredo,Cláudia P, AU - Doty,Richard L, AU - Takahashi,Reinaldo N, PY - 2009/8/19/entrez PY - 2009/8/19/pubmed PY - 2009/9/26/medline SP - 629 EP - 36 JF - Annals of the New York Academy of Sciences JO - Ann N Y Acad Sci VL - 1170 N2 - The presence of smell loss and the early pathological involvement of the olfactory pathways in the early stages of some neurodegenerative disorders are in accord with the tenants of the olfactory vector hypothesis. This hypothesis postulates that some such diseases may be caused or catalyzed by agents that enter the brain via the olfactory mucosa. In this study, rats infused intranasally (i.n.) with a low concentration of the proneurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) subsequently suffered olfactory, cognitive, and motor function impairments conceivably analogous to those observed during different stages of the development of Parkinson's disease (PD). Such infusion decreased the expression of the enzyme tyrosine hydroxylase in the olfactory bulb and substantia nigra by means of apoptotic mechanisms, reducing dopamine levels in different brain structures, such as the olfactory bulb, striatum, and prefrontal cortex. These findings reinforce the suggestion that the olfactory system may be a particularly sensitive route for the penetration of xenobiotic agents into the central nervous system and that the i.n. MPTP rat model may provide insight into the underlying mechanisms of PD pathogenesis, potentially leading to the development of new therapeutic strategies for this devastating disease. SN - 1749-6632 UR - https://www.unboundmedicine.com/medline/citation/19686204/Risk_is_in_the_air:_an_intranasal_MPTP__1_methyl_4_phenyl_1236_tetrahydropyridine__rat_model_of_Parkinson's_disease_ L2 - https://doi.org/10.1111/j.1749-6632.2009.03885.x DB - PRIME DP - Unbound Medicine ER -
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