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Validation of model for end-stage liver disease score to serum sodium ratio index as a prognostic predictor in patients with cirrhosis.
J Gastroenterol Hepatol. 2009 Sep; 24(9):1547-53.JG

Abstract

AIM

To evaluate the prognostic ability of model for end-stage liver disease (MELD) to serum sodium (SNa) ratio (MESO) index and to compare the predictive accuracy of the MESO index with the MELD score and the modified Child-Turcotte-Pugh (CTP) score for short-term survival in cirrhotic patients.

METHODS

A total of 256 patients with cirrhosis were retrospectively evaluated. The predictive accuracy of the MESO index, MELD score and modified CTP score were compared by the area under the receiver-operator characteristic curve (AUC).

RESULTS

Using 1-month and 3-month mortality as the end-point, overall, MESO and MELD were significantly better than the CTP score in predicting the risk of mortality at 1 month (AUC, 0.866,0.819 vs 0.722, P < 0.01) and 3 months (AUC, 0.875,0.820 vs 0.721, P < 0.01). In the low MELD group, the AUC of MESO index (0.758, 0.759) and CTP score (0.754, 0.732) were higher than that of the MELD score (0.608, 0.611) at 1 month and 3 months, respectively (P < 0.01). However, in the high MELD group, the AUC of MESO index (0.762, 0.779) and MELD (0.737, 0.773) were higher than that of the CTP score (0.710, 0.752) at 1 month and 3 months, respectively, although there were no significant differences (P > 0.05). With appropriate cut-offs for the MESO index, the mortality rate of patients in high MESO was higher (57.1% at 1 month and 69.2% at 3 months) than that of the low MESO (5.5% at 1 month and 7.9% at 3 months) (P < 0.01).

CONCLUSIONS

The MESO index, which adds SNa to MELD, is a useful prognostic marker and is found to be superior to the MELD score and modified CTP score for short-term prognostication of patients with cirrhosis.

Authors+Show Affiliations

Department of Gastroenterology, First Affiliated Hospital, China Medical University, Shenyang, Liaoning Province, China. lvxiaohui1122@163.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Validation Study

Language

eng

PubMed ID

19686416

Citation

Lv, Xiao-Hui, et al. "Validation of Model for End-stage Liver Disease Score to Serum Sodium Ratio Index as a Prognostic Predictor in Patients With Cirrhosis." Journal of Gastroenterology and Hepatology, vol. 24, no. 9, 2009, pp. 1547-53.
Lv XH, Liu HB, Wang Y, et al. Validation of model for end-stage liver disease score to serum sodium ratio index as a prognostic predictor in patients with cirrhosis. J Gastroenterol Hepatol. 2009;24(9):1547-53.
Lv, X. H., Liu, H. B., Wang, Y., Wang, B. Y., Song, M., & Sun, M. J. (2009). Validation of model for end-stage liver disease score to serum sodium ratio index as a prognostic predictor in patients with cirrhosis. Journal of Gastroenterology and Hepatology, 24(9), 1547-53. https://doi.org/10.1111/j.1440-1746.2009.05913.x
Lv XH, et al. Validation of Model for End-stage Liver Disease Score to Serum Sodium Ratio Index as a Prognostic Predictor in Patients With Cirrhosis. J Gastroenterol Hepatol. 2009;24(9):1547-53. PubMed PMID: 19686416.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Validation of model for end-stage liver disease score to serum sodium ratio index as a prognostic predictor in patients with cirrhosis. AU - Lv,Xiao-Hui, AU - Liu,Hong-Bo, AU - Wang,Ying, AU - Wang,Bing-Yuan, AU - Song,Min, AU - Sun,Ming-Jun, Y1 - 2009/08/03/ PY - 2009/8/19/entrez PY - 2009/8/19/pubmed PY - 2009/12/16/medline SP - 1547 EP - 53 JF - Journal of gastroenterology and hepatology JO - J. Gastroenterol. Hepatol. VL - 24 IS - 9 N2 - AIM: To evaluate the prognostic ability of model for end-stage liver disease (MELD) to serum sodium (SNa) ratio (MESO) index and to compare the predictive accuracy of the MESO index with the MELD score and the modified Child-Turcotte-Pugh (CTP) score for short-term survival in cirrhotic patients. METHODS: A total of 256 patients with cirrhosis were retrospectively evaluated. The predictive accuracy of the MESO index, MELD score and modified CTP score were compared by the area under the receiver-operator characteristic curve (AUC). RESULTS: Using 1-month and 3-month mortality as the end-point, overall, MESO and MELD were significantly better than the CTP score in predicting the risk of mortality at 1 month (AUC, 0.866,0.819 vs 0.722, P < 0.01) and 3 months (AUC, 0.875,0.820 vs 0.721, P < 0.01). In the low MELD group, the AUC of MESO index (0.758, 0.759) and CTP score (0.754, 0.732) were higher than that of the MELD score (0.608, 0.611) at 1 month and 3 months, respectively (P < 0.01). However, in the high MELD group, the AUC of MESO index (0.762, 0.779) and MELD (0.737, 0.773) were higher than that of the CTP score (0.710, 0.752) at 1 month and 3 months, respectively, although there were no significant differences (P > 0.05). With appropriate cut-offs for the MESO index, the mortality rate of patients in high MESO was higher (57.1% at 1 month and 69.2% at 3 months) than that of the low MESO (5.5% at 1 month and 7.9% at 3 months) (P < 0.01). CONCLUSIONS: The MESO index, which adds SNa to MELD, is a useful prognostic marker and is found to be superior to the MELD score and modified CTP score for short-term prognostication of patients with cirrhosis. SN - 1440-1746 UR - https://www.unboundmedicine.com/medline/citation/19686416/Validation_of_model_for_end_stage_liver_disease_score_to_serum_sodium_ratio_index_as_a_prognostic_predictor_in_patients_with_cirrhosis_ L2 - https://doi.org/10.1111/j.1440-1746.2009.05913.x DB - PRIME DP - Unbound Medicine ER -