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The influence of microglia on the pathogenesis of Parkinson's disease.
Prog Neurobiol. 2009 Nov; 89(3):277-87.PN

Abstract

Parkinson's disease (PD) is characterised by degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc). Inflammation may be associated with the neuropathology of PD due to the following accumulating evidence: excessive microglial activation and increased levels of the pro-inflammatory cytokines tumour necrosis factor-alpha and interleukin-1beta in the SNpc of patients with PD; the emergence of PD-like symptoms following influenza infection; the increased susceptibility to PD associated with bacterial vaginosis; the presence of inflammatory mediators and activators in animal models of PD; the ability of anti-inflammatory drugs to decrease susceptibility to PD; and the emerging possibility of the use of microglial activation inhibitors as a therapy in PD. In this review, we will discuss the role of inflammation in PD. We will focus on the influence of microglia in the pathogenesis of PD and discuss potential therapeutic interventions for PD, that target microglia.

Authors+Show Affiliations

Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19686799

Citation

Long-Smith, Caitríona M., et al. "The Influence of Microglia On the Pathogenesis of Parkinson's Disease." Progress in Neurobiology, vol. 89, no. 3, 2009, pp. 277-87.
Long-Smith CM, Sullivan AM, Nolan YM. The influence of microglia on the pathogenesis of Parkinson's disease. Prog Neurobiol. 2009;89(3):277-87.
Long-Smith, C. M., Sullivan, A. M., & Nolan, Y. M. (2009). The influence of microglia on the pathogenesis of Parkinson's disease. Progress in Neurobiology, 89(3), 277-87. https://doi.org/10.1016/j.pneurobio.2009.08.001
Long-Smith CM, Sullivan AM, Nolan YM. The Influence of Microglia On the Pathogenesis of Parkinson's Disease. Prog Neurobiol. 2009;89(3):277-87. PubMed PMID: 19686799.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The influence of microglia on the pathogenesis of Parkinson's disease. AU - Long-Smith,Caitríona M, AU - Sullivan,Aideen M, AU - Nolan,Yvonne M, Y1 - 2009/08/15/ PY - 2009/05/14/received PY - 2009/08/08/revised PY - 2009/08/10/accepted PY - 2009/8/19/entrez PY - 2009/8/19/pubmed PY - 2010/1/13/medline SP - 277 EP - 87 JF - Progress in neurobiology JO - Prog Neurobiol VL - 89 IS - 3 N2 - Parkinson's disease (PD) is characterised by degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc). Inflammation may be associated with the neuropathology of PD due to the following accumulating evidence: excessive microglial activation and increased levels of the pro-inflammatory cytokines tumour necrosis factor-alpha and interleukin-1beta in the SNpc of patients with PD; the emergence of PD-like symptoms following influenza infection; the increased susceptibility to PD associated with bacterial vaginosis; the presence of inflammatory mediators and activators in animal models of PD; the ability of anti-inflammatory drugs to decrease susceptibility to PD; and the emerging possibility of the use of microglial activation inhibitors as a therapy in PD. In this review, we will discuss the role of inflammation in PD. We will focus on the influence of microglia in the pathogenesis of PD and discuss potential therapeutic interventions for PD, that target microglia. SN - 1873-5118 UR - https://www.unboundmedicine.com/medline/citation/19686799/The_influence_of_microglia_on_the_pathogenesis_of_Parkinson's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0301-0082(09)00129-4 DB - PRIME DP - Unbound Medicine ER -