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Assessment of risk and prophylaxis for deep vein thrombosis and pulmonary embolism in medically ill patients during their early days of hospital stay at a tertiary care center in a developing country.
Vasc Health Risk Manag 2009; 5:643-8VH

Abstract

AIM

Deep vein thrombosis (DVT) and pulmonary thromboembolism (PE) are important causes of morbidity and mortality in medically ill patients. This study was done to assess risk factors and prophylaxis given for DVT and PE in newly admitted medically ill patients during the first two weeks of their hospital stay at a tertiary care center hospital in India.

METHODS

All patients within one week of their admission in intensive care unit (ICU) and wards were enrolled in the study after an informed written consent. Patients who had DVT prophylaxis within the past month or any contraindications for DVT prophylaxis were excluded. A structured proforma was designed and effective risk stratification for DVT was done. Patients were followed for up to two weeks to record any changes in the risk categories and document any signs of PE or DVT if present. Any prophylaxis given for DVT or PE was noted.

RESULTS

Seventy-five percent of patients had the highest risk for DVT and PE. Only 12.5% had DVT prophylaxis within the first two days of admission. Within two weeks of admission, 30.8% of patients were discharged, and 16.2% died. 72.6% of the patients still in the wards belonged to the highest risk category. Clinical signs and symptoms of DVT and PE were present in 25.8% and 9.8% of patients, respectively after the second week of admission. 86% of symptomatic patients belonged to the highest risk category initially and none of them received any prophylaxis. 21.6% of the highest risk category patients died within two weeks of their admission. A statistically significant correlation was found between mortality and risk score of the patients for DVT and between lack of prophylaxis and mortality (p < 0.05).

CONCLUSION

A significant risk for DVT and PE exists in medically ill patients, but only a small proportion of the patients are given prophylaxis. This study underlines the need to aggressively implement DVT risk stratification strategy in medical patients and provide prophylaxis unless contraindicated.

Authors+Show Affiliations

Department of Medicine, All India Institute of Medical Sciences, New Delhi, India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19688105

Citation

Pandey, Ambarish, et al. "Assessment of Risk and Prophylaxis for Deep Vein Thrombosis and Pulmonary Embolism in Medically Ill Patients During Their Early Days of Hospital Stay at a Tertiary Care Center in a Developing Country." Vascular Health and Risk Management, vol. 5, 2009, pp. 643-8.
Pandey A, Patni N, Singh M, et al. Assessment of risk and prophylaxis for deep vein thrombosis and pulmonary embolism in medically ill patients during their early days of hospital stay at a tertiary care center in a developing country. Vasc Health Risk Manag. 2009;5:643-8.
Pandey, A., Patni, N., Singh, M., & Guleria, R. (2009). Assessment of risk and prophylaxis for deep vein thrombosis and pulmonary embolism in medically ill patients during their early days of hospital stay at a tertiary care center in a developing country. Vascular Health and Risk Management, 5, pp. 643-8.
Pandey A, et al. Assessment of Risk and Prophylaxis for Deep Vein Thrombosis and Pulmonary Embolism in Medically Ill Patients During Their Early Days of Hospital Stay at a Tertiary Care Center in a Developing Country. Vasc Health Risk Manag. 2009;5:643-8. PubMed PMID: 19688105.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Assessment of risk and prophylaxis for deep vein thrombosis and pulmonary embolism in medically ill patients during their early days of hospital stay at a tertiary care center in a developing country. AU - Pandey,Ambarish, AU - Patni,Nivedita, AU - Singh,Mansher, AU - Guleria,Randeep, Y1 - 2009/08/06/ PY - 2009/8/19/entrez PY - 2009/8/19/pubmed PY - 2009/10/30/medline KW - DVT prophylaxis KW - deep venous thrombosis KW - pulmonary embolism KW - risk stratification SP - 643 EP - 8 JF - Vascular health and risk management JO - Vasc Health Risk Manag VL - 5 N2 - AIM: Deep vein thrombosis (DVT) and pulmonary thromboembolism (PE) are important causes of morbidity and mortality in medically ill patients. This study was done to assess risk factors and prophylaxis given for DVT and PE in newly admitted medically ill patients during the first two weeks of their hospital stay at a tertiary care center hospital in India. METHODS: All patients within one week of their admission in intensive care unit (ICU) and wards were enrolled in the study after an informed written consent. Patients who had DVT prophylaxis within the past month or any contraindications for DVT prophylaxis were excluded. A structured proforma was designed and effective risk stratification for DVT was done. Patients were followed for up to two weeks to record any changes in the risk categories and document any signs of PE or DVT if present. Any prophylaxis given for DVT or PE was noted. RESULTS: Seventy-five percent of patients had the highest risk for DVT and PE. Only 12.5% had DVT prophylaxis within the first two days of admission. Within two weeks of admission, 30.8% of patients were discharged, and 16.2% died. 72.6% of the patients still in the wards belonged to the highest risk category. Clinical signs and symptoms of DVT and PE were present in 25.8% and 9.8% of patients, respectively after the second week of admission. 86% of symptomatic patients belonged to the highest risk category initially and none of them received any prophylaxis. 21.6% of the highest risk category patients died within two weeks of their admission. A statistically significant correlation was found between mortality and risk score of the patients for DVT and between lack of prophylaxis and mortality (p < 0.05). CONCLUSION: A significant risk for DVT and PE exists in medically ill patients, but only a small proportion of the patients are given prophylaxis. This study underlines the need to aggressively implement DVT risk stratification strategy in medical patients and provide prophylaxis unless contraindicated. SN - 1178-2048 UR - https://www.unboundmedicine.com/medline/citation/19688105/Assessment_of_risk_and_prophylaxis_for_deep_vein_thrombosis_and_pulmonary_embolism_in_medically_ill_patients_during_their_early_days_of_hospital_stay_at_a_tertiary_care_center_in_a_developing_country_ L2 - https://www.dovepress.com/articles.php?article_id=3414 DB - PRIME DP - Unbound Medicine ER -