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Quercitrin, a bioflavonoid improves glucose homeostasis in streptozotocin-induced diabetic tissues by altering glycolytic and gluconeogenic enzymes.
Fundam Clin Pharmacol. 2010 Jun; 24(3):357-64.FC

Abstract

The present study is an investigation into the role of quercitrin on carbohydrate metabolism in normal and streptozotocin (STZ)-induced diabetic rats. Administration of STZ leads to a significant increase (P < 0.05) in fasting plasma glucose and a decrease in insulin levels. The content of glycogen is significantly decreased (P < 0.05) in liver and muscle, but increased in the kidney. The activity of hexokinase decreased whereas the activities of glucose 6-phosphatase and fructose 1,6-bisphosphatase significantly increased (P < 0.05) in the tissues. Oral administration of quercitrin (30 mg/kg) to diabetic rats for a period of 30 days resulted in significant (P < 0.05) alterations in the parameters studied but not in normal rats. A decrease of plasma glucose and increase in insulin levels were observed along with the restoration of glycogen content and the activities of carbohydrate metabolic enzymes in quercitrin-treated diabetic rats. The histopathological study of the pancreas revealed the protective role of quercitrin. There was an expansion of the islets and decreased fatty infiltrate of the islets in quercitrin treated diabetic rats. In normal rats treated with quercitrin, we could not observe any significant change in all the parameters studied. Combined, these results show that quercitrin plays a positive role in carbohydrate metabolism and antioxidant status in diabetic rats.

Authors+Show Affiliations

Department of Biochemistry, K.M.G College of Arts and Science, Gudiyatham, Vellore District, Tamil Nadu 632 602, India.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

19689449

Citation

Babujanarthanam, Ranganathan, et al. "Quercitrin, a Bioflavonoid Improves Glucose Homeostasis in Streptozotocin-induced Diabetic Tissues By Altering Glycolytic and Gluconeogenic Enzymes." Fundamental & Clinical Pharmacology, vol. 24, no. 3, 2010, pp. 357-64.
Babujanarthanam R, Kavitha P, Pandian MR. Quercitrin, a bioflavonoid improves glucose homeostasis in streptozotocin-induced diabetic tissues by altering glycolytic and gluconeogenic enzymes. Fundam Clin Pharmacol. 2010;24(3):357-64.
Babujanarthanam, R., Kavitha, P., & Pandian, M. R. (2010). Quercitrin, a bioflavonoid improves glucose homeostasis in streptozotocin-induced diabetic tissues by altering glycolytic and gluconeogenic enzymes. Fundamental & Clinical Pharmacology, 24(3), 357-64. https://doi.org/10.1111/j.1472-8206.2009.00771.x
Babujanarthanam R, Kavitha P, Pandian MR. Quercitrin, a Bioflavonoid Improves Glucose Homeostasis in Streptozotocin-induced Diabetic Tissues By Altering Glycolytic and Gluconeogenic Enzymes. Fundam Clin Pharmacol. 2010;24(3):357-64. PubMed PMID: 19689449.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Quercitrin, a bioflavonoid improves glucose homeostasis in streptozotocin-induced diabetic tissues by altering glycolytic and gluconeogenic enzymes. AU - Babujanarthanam,Ranganathan, AU - Kavitha,Purushothaman, AU - Pandian,Moses Rajasekara, Y1 - 2009/08/17/ PY - 2009/8/20/entrez PY - 2009/8/20/pubmed PY - 2011/3/12/medline SP - 357 EP - 64 JF - Fundamental & clinical pharmacology JO - Fundam Clin Pharmacol VL - 24 IS - 3 N2 - The present study is an investigation into the role of quercitrin on carbohydrate metabolism in normal and streptozotocin (STZ)-induced diabetic rats. Administration of STZ leads to a significant increase (P < 0.05) in fasting plasma glucose and a decrease in insulin levels. The content of glycogen is significantly decreased (P < 0.05) in liver and muscle, but increased in the kidney. The activity of hexokinase decreased whereas the activities of glucose 6-phosphatase and fructose 1,6-bisphosphatase significantly increased (P < 0.05) in the tissues. Oral administration of quercitrin (30 mg/kg) to diabetic rats for a period of 30 days resulted in significant (P < 0.05) alterations in the parameters studied but not in normal rats. A decrease of plasma glucose and increase in insulin levels were observed along with the restoration of glycogen content and the activities of carbohydrate metabolic enzymes in quercitrin-treated diabetic rats. The histopathological study of the pancreas revealed the protective role of quercitrin. There was an expansion of the islets and decreased fatty infiltrate of the islets in quercitrin treated diabetic rats. In normal rats treated with quercitrin, we could not observe any significant change in all the parameters studied. Combined, these results show that quercitrin plays a positive role in carbohydrate metabolism and antioxidant status in diabetic rats. SN - 1472-8206 UR - https://www.unboundmedicine.com/medline/citation/19689449/Quercitrin_a_bioflavonoid_improves_glucose_homeostasis_in_streptozotocin_induced_diabetic_tissues_by_altering_glycolytic_and_gluconeogenic_enzymes_ L2 - https://doi.org/10.1111/j.1472-8206.2009.00771.x DB - PRIME DP - Unbound Medicine ER -