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Small airway remodeling in idiopathic interstitial pneumonias: a pathological study.
Respiration. 2010; 79(4):322-32.R

Abstract

BACKGROUND

Few studies have addressed small airway (SA) histopathological changes and their possible role in the remodeling process in idiopathic interstitial pneumonias.

OBJECTIVES

To study morphological, morphometrical and immunohistochemical features of SA in idiopathic pulmonary fibrosis (usual interstitial pneumonia, UIP) and nonspecific interstitial pneumonia (NSIP).

METHODS

We analyzed SA pathology in lung biopsies from 29 patients with UIP and 8 with NSIP. Biopsies were compared with lung tissue from 13 patients with constrictive bronchiolitis (CB) as positive controls and 10 normal autopsied control lungs. We semi-quantitatively analyzed SA structure, inflammation, architectural features and the bronchiolar epithelial immunohistochemical expression of TGF-beta, MMP-2, 7, 9, and their tissue inhibitors (TIMP-1, 2).

RESULTS

Compared to controls, patients with UIP, NSIP and CB presented increased bronchiolar inflammation, peribronchiolar inflammation and fibrosis and decreased luminal areas. UIP patients had thicker walls due to an increase in most airway compartments. NSIP patients presented increased epithelial areas, whereas patients with CB had larger inner wall areas. All of the groups studied presented increased bronchiolar expression of MMP-7 and MMP-9, compared to the controls.

CONCLUSION

We conclude that SAs are pathologically altered and may take part in the lung-remodeling process in idiopathic interstitial pneumonias.

Authors+Show Affiliations

Pathology Department, Hospital das Clinicas, University of Sao Paulo Medical School, São Paulo, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19690403

Citation

Figueira de Mello, George Castro, et al. "Small Airway Remodeling in Idiopathic Interstitial Pneumonias: a Pathological Study." Respiration; International Review of Thoracic Diseases, vol. 79, no. 4, 2010, pp. 322-32.
Figueira de Mello GC, Ribeiro Carvalho CR, Adib Kairalla R, et al. Small airway remodeling in idiopathic interstitial pneumonias: a pathological study. Respiration. 2010;79(4):322-32.
Figueira de Mello, G. C., Ribeiro Carvalho, C. R., Adib Kairalla, R., Nascimento Saldiva, P. H., Fernezlian, S., Ferraz Silva, L. F., Dolhnikoff, M., & Mauad, T. (2010). Small airway remodeling in idiopathic interstitial pneumonias: a pathological study. Respiration; International Review of Thoracic Diseases, 79(4), 322-32. https://doi.org/10.1159/000235722
Figueira de Mello GC, et al. Small Airway Remodeling in Idiopathic Interstitial Pneumonias: a Pathological Study. Respiration. 2010;79(4):322-32. PubMed PMID: 19690403.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Small airway remodeling in idiopathic interstitial pneumonias: a pathological study. AU - Figueira de Mello,George Castro, AU - Ribeiro Carvalho,Carlos Roberto, AU - Adib Kairalla,Ronaldo, AU - Nascimento Saldiva,Paulo Hilário, AU - Fernezlian,Sandra, AU - Ferraz Silva,Luiz Fernando, AU - Dolhnikoff,Marisa, AU - Mauad,Thais, Y1 - 2009/08/19/ PY - 2008/10/20/received PY - 2009/06/01/accepted PY - 2009/8/20/entrez PY - 2009/8/20/pubmed PY - 2010/5/27/medline SP - 322 EP - 32 JF - Respiration; international review of thoracic diseases JO - Respiration VL - 79 IS - 4 N2 - BACKGROUND: Few studies have addressed small airway (SA) histopathological changes and their possible role in the remodeling process in idiopathic interstitial pneumonias. OBJECTIVES: To study morphological, morphometrical and immunohistochemical features of SA in idiopathic pulmonary fibrosis (usual interstitial pneumonia, UIP) and nonspecific interstitial pneumonia (NSIP). METHODS: We analyzed SA pathology in lung biopsies from 29 patients with UIP and 8 with NSIP. Biopsies were compared with lung tissue from 13 patients with constrictive bronchiolitis (CB) as positive controls and 10 normal autopsied control lungs. We semi-quantitatively analyzed SA structure, inflammation, architectural features and the bronchiolar epithelial immunohistochemical expression of TGF-beta, MMP-2, 7, 9, and their tissue inhibitors (TIMP-1, 2). RESULTS: Compared to controls, patients with UIP, NSIP and CB presented increased bronchiolar inflammation, peribronchiolar inflammation and fibrosis and decreased luminal areas. UIP patients had thicker walls due to an increase in most airway compartments. NSIP patients presented increased epithelial areas, whereas patients with CB had larger inner wall areas. All of the groups studied presented increased bronchiolar expression of MMP-7 and MMP-9, compared to the controls. CONCLUSION: We conclude that SAs are pathologically altered and may take part in the lung-remodeling process in idiopathic interstitial pneumonias. SN - 1423-0356 UR - https://www.unboundmedicine.com/medline/citation/19690403/Small_airway_remodeling_in_idiopathic_interstitial_pneumonias:_a_pathological_study_ L2 - https://www.karger.com?DOI=10.1159/000235722 DB - PRIME DP - Unbound Medicine ER -