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Restless legs syndrome in Parkinson's disease.
Mov Disord. 2009 Oct 30; 24(14):2076-80.MD

Abstract

We aimed to investigate the prevalence of restless legs syndrome (RLS) according to essential diagnostic criteria, and to explore potential associations with clinical features, especially motor fluctuations, in a cohort of 113 patients with idiopathic Parkinson's disease (PD). Twenty-eight (24%) fulfilled essential diagnostic criteria for RLS. They were younger (63.1 +/- 8.6 vs. 68.8 +/- 9.0 years; P = 0.004), had an earlier onset of PD (54.1 +/- 9.5 vs. 59.2 +/- 10.3 years; P = 0.018), and received lower levodopa equivalent doses (578.4 +/- 382.2 vs. 779.1 +/- 459.6 mg/day; P = 0.04) than patients with PD who scored negative for RLS. In 23 patients (82%), RLS symptom onset was after PD onset (mean interval, 4.5 +/- 3.7 years). The majority (n = 17, 61%) who scored positive for RLS reported that the urge to move the legs and unpleasant sensations were associated with wearing off, raising the possibility of RLS mimics in fluctuating patients with PD.

Authors+Show Affiliations

Department of Neurology, Innsbruck Medical University, Innsbruck, Austria.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19691124

Citation

Peralta, Cecilia M., et al. "Restless Legs Syndrome in Parkinson's Disease." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 24, no. 14, 2009, pp. 2076-80.
Peralta CM, Frauscher B, Seppi K, et al. Restless legs syndrome in Parkinson's disease. Mov Disord. 2009;24(14):2076-80.
Peralta, C. M., Frauscher, B., Seppi, K., Wolf, E., Wenning, G. K., Högl, B., & Poewe, W. (2009). Restless legs syndrome in Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society, 24(14), 2076-80. https://doi.org/10.1002/mds.22694
Peralta CM, et al. Restless Legs Syndrome in Parkinson's Disease. Mov Disord. 2009 Oct 30;24(14):2076-80. PubMed PMID: 19691124.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Restless legs syndrome in Parkinson's disease. AU - Peralta,Cecilia M, AU - Frauscher,Birgit, AU - Seppi,Klaus, AU - Wolf,Elisabeth, AU - Wenning,Gregor K, AU - Högl,Birgit, AU - Poewe,Werner, PY - 2009/8/20/entrez PY - 2009/8/20/pubmed PY - 2010/1/13/medline SP - 2076 EP - 80 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 24 IS - 14 N2 - We aimed to investigate the prevalence of restless legs syndrome (RLS) according to essential diagnostic criteria, and to explore potential associations with clinical features, especially motor fluctuations, in a cohort of 113 patients with idiopathic Parkinson's disease (PD). Twenty-eight (24%) fulfilled essential diagnostic criteria for RLS. They were younger (63.1 +/- 8.6 vs. 68.8 +/- 9.0 years; P = 0.004), had an earlier onset of PD (54.1 +/- 9.5 vs. 59.2 +/- 10.3 years; P = 0.018), and received lower levodopa equivalent doses (578.4 +/- 382.2 vs. 779.1 +/- 459.6 mg/day; P = 0.04) than patients with PD who scored negative for RLS. In 23 patients (82%), RLS symptom onset was after PD onset (mean interval, 4.5 +/- 3.7 years). The majority (n = 17, 61%) who scored positive for RLS reported that the urge to move the legs and unpleasant sensations were associated with wearing off, raising the possibility of RLS mimics in fluctuating patients with PD. SN - 1531-8257 UR - https://www.unboundmedicine.com/medline/citation/19691124/Restless_legs_syndrome_in_Parkinson's_disease_ L2 - https://doi.org/10.1002/mds.22694 DB - PRIME DP - Unbound Medicine ER -