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Monoterpenes from Paeonia albiflora and their inhibitory activity on nitric oxide production by lipopolysaccharide-activated microglia.
J Nat Prod. 2009 Sep; 72(9):1579-84.JN

Abstract

Eleven new monoterpenes, paeonidangenin (1), paeonidanin A (2), paeonidanin B (3), paeonidanin C (4), paeonidanin D (5), paeonidanin E (6), paeoniflorone (7), 4-O-methylbenzoylpaeoniflorin (8), 4-O-methylgalloylpaeoniflorin (9), 4-O-methyldebenzoylpaeoniflorin (10), and 4-O-methylalbiflorin (11), were isolated from the 60% ethanol extract of the roots of Paeonia albiflora. Their structures were determined primarily on the basis of 1D and 2D NMR techniques and MS studies. Paeonidanins D (5) and E (6) are unprecedented examples of "cage-like" monoterpene dimers. The inhibitory effects of the isolated compounds on nitric oxide production by lipopolysaccharide (LPS)-activated N9 microglia were evaluated.

Authors+Show Affiliations

Department of Natural Products Chemistry, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University 81, No. 103 Road WenHua, Shenyang, People's Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19691309

Citation

Duan, Wen-Juan, et al. "Monoterpenes From Paeonia Albiflora and Their Inhibitory Activity On Nitric Oxide Production By Lipopolysaccharide-activated Microglia." Journal of Natural Products, vol. 72, no. 9, 2009, pp. 1579-84.
Duan WJ, Yang JY, Chen LX, et al. Monoterpenes from Paeonia albiflora and their inhibitory activity on nitric oxide production by lipopolysaccharide-activated microglia. J Nat Prod. 2009;72(9):1579-84.
Duan, W. J., Yang, J. Y., Chen, L. X., Zhang, L. J., Jiang, Z. H., Cai, X. D., Zhang, X., & Qiu, F. (2009). Monoterpenes from Paeonia albiflora and their inhibitory activity on nitric oxide production by lipopolysaccharide-activated microglia. Journal of Natural Products, 72(9), 1579-84. https://doi.org/10.1021/np9001898
Duan WJ, et al. Monoterpenes From Paeonia Albiflora and Their Inhibitory Activity On Nitric Oxide Production By Lipopolysaccharide-activated Microglia. J Nat Prod. 2009;72(9):1579-84. PubMed PMID: 19691309.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Monoterpenes from Paeonia albiflora and their inhibitory activity on nitric oxide production by lipopolysaccharide-activated microglia. AU - Duan,Wen-Juan, AU - Yang,Jing-Yu, AU - Chen,Li-Xia, AU - Zhang,Li-Jia, AU - Jiang,Zhi-Hu, AU - Cai,Xu-Dong, AU - Zhang,Xue, AU - Qiu,Feng, PY - 2009/8/21/entrez PY - 2009/8/21/pubmed PY - 2009/10/22/medline SP - 1579 EP - 84 JF - Journal of natural products JO - J Nat Prod VL - 72 IS - 9 N2 - Eleven new monoterpenes, paeonidangenin (1), paeonidanin A (2), paeonidanin B (3), paeonidanin C (4), paeonidanin D (5), paeonidanin E (6), paeoniflorone (7), 4-O-methylbenzoylpaeoniflorin (8), 4-O-methylgalloylpaeoniflorin (9), 4-O-methyldebenzoylpaeoniflorin (10), and 4-O-methylalbiflorin (11), were isolated from the 60% ethanol extract of the roots of Paeonia albiflora. Their structures were determined primarily on the basis of 1D and 2D NMR techniques and MS studies. Paeonidanins D (5) and E (6) are unprecedented examples of "cage-like" monoterpene dimers. The inhibitory effects of the isolated compounds on nitric oxide production by lipopolysaccharide (LPS)-activated N9 microglia were evaluated. SN - 1520-6025 UR - https://www.unboundmedicine.com/medline/citation/19691309/Monoterpenes_from_Paeonia_albiflora_and_their_inhibitory_activity_on_nitric_oxide_production_by_lipopolysaccharide_activated_microglia_ L2 - https://doi.org/10.1021/np9001898 DB - PRIME DP - Unbound Medicine ER -