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Influenza A (H(1)N(1)) Antiviral and Cytotoxic Agents from Ferula assa-foetida.
J Nat Prod. 2009 Sep; 72(9):1568-72.JN

Abstract

Two new sesquiterpene coumarins, designated 5'-acetoxy-8'-hydroxyumbelliprenin (1) and 10'R-acetoxy-11'-hydroxyumbelliprenin (2), and a new diterpene, 15-hydroxy-6-en-dehydroabietic acid (3), along with 27 known compounds, were isolated from a CHCl(3)-soluble extract of Ferula assa-foetida through bioassay-guided fractionation. The structures of the new metabolites 1-3 were identified by spectroscopic data interpretation and by the Mosher ester method. Compounds 4 and 6-13 showed greater potency against influenza A virus (H(1)N(1)) (IC(50) 0.26-0.86 microg/mL) than amantadine (IC(50) 0.92 microg/mL), and 11 exhibited the best potency (IC(50) 0.51, 2.6, and 3.4 microg/mL) of these compounds against the HepG2, Hep3B, and MCF-7 cancer cell lines, respectively.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Lee CL
Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan, Republic of China.
Chiang LC
No affiliation info available
Cheng LH
No affiliation info available
Liaw CC
No affiliation info available
Abd El-Razek MH
No affiliation info available
Chang FR
No affiliation info available
Wu YC
No affiliation info available

MeSH

AnimalsAntineoplastic Agents, PhytogenicAntiviral AgentsChlorocebus aethiopsCoumarinsFerulaHumansInfluenza A Virus, H1N1 SubtypeInfluenza, HumanMolecular StructurePlants, MedicinalSesquiterpenes

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19691312

Citation

Lee, Chia-Lin, et al. "Influenza a (H(1)N(1)) Antiviral and Cytotoxic Agents From Ferula Assa-foetida." Journal of Natural Products, vol. 72, no. 9, 2009, pp. 1568-72.
Lee CL, Chiang LC, Cheng LH, et al. Influenza A (H(1)N(1)) Antiviral and Cytotoxic Agents from Ferula assa-foetida. J Nat Prod. 2009;72(9):1568-72.
Lee, C. L., Chiang, L. C., Cheng, L. H., Liaw, C. C., Abd El-Razek, M. H., Chang, F. R., & Wu, Y. C. (2009). Influenza A (H(1)N(1)) Antiviral and Cytotoxic Agents from Ferula assa-foetida. Journal of Natural Products, 72(9), 1568-72. https://doi.org/10.1021/np900158f
Lee CL, et al. Influenza a (H(1)N(1)) Antiviral and Cytotoxic Agents From Ferula Assa-foetida. J Nat Prod. 2009;72(9):1568-72. PubMed PMID: 19691312.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influenza A (H(1)N(1)) Antiviral and Cytotoxic Agents from Ferula assa-foetida. AU - Lee,Chia-Lin, AU - Chiang,Lien-Chai, AU - Cheng,Li-Hung, AU - Liaw,Chih-Chuang, AU - Abd El-Razek,Mohamed H, AU - Chang,Fang-Rong, AU - Wu,Yang-Chang, PY - 2009/8/21/entrez PY - 2009/8/21/pubmed PY - 2009/10/22/medline SP - 1568 EP - 72 JF - Journal of natural products JO - J Nat Prod VL - 72 IS - 9 N2 - Two new sesquiterpene coumarins, designated 5'-acetoxy-8'-hydroxyumbelliprenin (1) and 10'R-acetoxy-11'-hydroxyumbelliprenin (2), and a new diterpene, 15-hydroxy-6-en-dehydroabietic acid (3), along with 27 known compounds, were isolated from a CHCl(3)-soluble extract of Ferula assa-foetida through bioassay-guided fractionation. The structures of the new metabolites 1-3 were identified by spectroscopic data interpretation and by the Mosher ester method. Compounds 4 and 6-13 showed greater potency against influenza A virus (H(1)N(1)) (IC(50) 0.26-0.86 microg/mL) than amantadine (IC(50) 0.92 microg/mL), and 11 exhibited the best potency (IC(50) 0.51, 2.6, and 3.4 microg/mL) of these compounds against the HepG2, Hep3B, and MCF-7 cancer cell lines, respectively. SN - 1520-6025 UR - https://www.unboundmedicine.com/medline/citation/19691312/Influenza_A__H_1_N_1___Antiviral_and_Cytotoxic_Agents_from_Ferula_assa_foetida_ L2 - https://doi.org/10.1021/np900158f DB - PRIME DP - Unbound Medicine ER -